Protein Alignment FASN3 and pks-1

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: NP_508923.2
• Gene: pks-1 / 180815
• WormBaseID: WBGene00016558
• Length: 7752
• Species: Caenorhabditis elegans
• Alignment Length: 2311
• Identity: 493/2311 - (21%)
• Similarity: 848/2311 - (36%)
• Gaps: 683/2311 - (29%)

  Fly    73 DLEKFDATFFGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTW 137
            |:.:||.:||.:...:|..:|||.|:|:|...|.:.:|||    :..|..||::|  :.|.|
 Worm  1954 DVTQFDPSFFKISKSEAELIDPQQRLLLECVQECLENSGV----IETSNVGVFVG--LMEKE--- 2009

  Fly   138 FYEKV--SSGGFGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAA 200
             |:.:  ||....:.|...|::|.|::|..|..|||..:|||||||:.||:.|.:|:.:......
 Worm  2010 -YQDMMESSSILAMLGSMAAVIAGRVNYIFGCYGPSVTIDTACSSSLVALEMAINALLDNRCSKV 2073

  Fly   201 IIGGSNLLLHPFVTLQFARLG--VLAPDGFCRPFDKNASGYTRSETINCLFLQKKK---HAKRVY 260
            |:.|.||:|:.  ..|..|..  :|:..|....||..||||.||:....|.|:..|   |    |
 Worm  2074 IVAGVNLILNE--KGQGLRTNGKMLSQHGMSLSFDSRASGYGRSDGCVVLMLELAKPNFH----Y 2132

  Fly   261 ASIVYSKTNCDGYKPEGITYPSGIVQEKLLDQFYKDIDHKPS-DLGYLEAHSTGTVVGDPEECKA 324
            .|.:.|.....|.:...:|.|:|:..:.||...   |:..|| .:.|.|||.|||.:|||.|...
 Worm  2133 MSTIQSVNVNHGGRSVSLTAPNGVAHKMLLTSV---INQSPSLAIDYWEAHGTGTPLGDPIEFNT 2194

  Fly   325 IDNVLCSQREEPLLVGSVKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEV--KQIIAPLA 387
            :.::|     :.:::||||:::||.||::|.|.|:| .|...|....|.:....|  |.|.|  .
 Worm  2195 LSSIL-----QNIIIGSVKASLGHGEASAGTCGLLK-LFLMLTYQYVPTLIHFHVLNKDINA--G 2251

  Fly   388 EGRLIVVKDVVPLPKPYIGINSFGFGGANAHALLKGYPKSKNNFGIPADDVPRLLTWAGRTEEAV 452
            ..||.::.:...|..  .||:|||..|.||.|             |..:|..:|
 Worm  2252 SIRLPIIGEDSELVS--AGISSFGVSGTNAAA-------------IAFNDNNKL----------- 2290

  Fly   453 EEIFNAVEKN---PLDAEFIGLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKL---LAKDVQHYTG 511
             |.:..:.|.   |:.|:....|.|::::.:|.:......|        |.:   ||.:..|:|
 Worm  2291 -EPYIPIHKYYILPISAKNQISLDNLEKQILSVIPLTDVPI--------CNIASALANNRSHFT- 2345

  Fly   512 LQRPIVWVYSGMGSQWNQMGNSLMIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILN- 575
            ::..::...||:.:. ...|....:..:.|..|::|..:|.|   :|:.....|:.....::.|
 Worm  2346 IRNALIVSNSGIVNS-KMEGKPHRVAKKDRYHVKLCDSLLDA---SLLQYDVINETYTVASLKNP 2406

  Fly   576 -SFVGIAAVQIGLTDVLRSLNIQPDYI-IGHSVGE--LGCAYADGGLTAQQMILAAYYRGRVSVD 636
             ||    |::..:...|.||:   :|| |..|.||  |....|:|.|..:.     :.:..:.:.
 Worm  2407 QSF----AMKFAIIKFLTSLS---EYIEIVASDGEELLAVLLANGSLKWEN-----FNKTMIELP 2459

  Fly   637 LEKIRGSMAAVGLGYKTVLHMLPKSIETACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPC 701
            :..:....|...|...|...:  ||.:|.    |:|..:..|: ::.:.:..|...|
 Worm  2460 IGSLLTEFADHDLNSTTSSSI--KSYQTQ----PESHNLDSPM-ELMKLIMKLYITG-------- 2509

  Fly   702 SNIAYHSKYISHMGPPLLNYMNEIIPHPKPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNS 766
                |...:.:...|     :.:.|             ::|...:||                .:
 Worm  2510 ----YDVDWATVYSP-----VEQFI-------------ALPNYQFNK----------------QT 2536

  Fly   767 VLFDETFSLIPKNSLTIEVAPHGLLGAILKRSMPSGVHIPLTNRGNQ-NNASFFLSALGKIY--- 827
            :.|:|          .:|:..|.|:|.|.:.|..:   :.|.|:.:: .:..||   .||..
 Worm  2537 LWFEE----------RLEIVDHYLIGTIDEESEDT---LILKNQISELRHPQFF---KGKPLDVG 2585

  Fly   828 -LNGVLLPAANLYERIQFPVSRTTPSVSSLIR--WDHSEDWFVTKYE-----NMKTKSSGERVFS 884
             ::.:.:.|..:...|.|.:......:.:|.:  |..:.   ||:.|     |:.....|:|:||
 Worm  2586 TMSEIAIEALKIRNEIPFSIQNLKTELITLTKPAWLETN---VTRNEDDEGFNVSAYIDGQRLFS 2647

  Fly   885 VNLASDNEEFLSGHIIDGKILVPA--------TCYLQYVWETFSLMYHGPSYMDVPVEFEDIRFI 941
            :|.:|...:         .|.|||        ..||:.........:....|:|...|....|
 Worm  2648 LNASSVEIQ---------NIEVPAVEVQIPDKVVYLKECPNAVIRRHRNMVYVDSRAEQSPFR-- 2701

  Fly   942 RATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENPSIPEVYNFQSKSKFPMIAKKD 1006
                                        ..::|:..||.....||                   |
 Worm  2702 ----------------------------TANIVLNEIIGFAPTPS-------------------D 2719

  Fly  1007 FYKEL--KLRGYHYNGAFQAVNLARSDGLFGRVQWNYNWVTFMDAMLQIQILGTDSRNLLLPTKI 1069
            .:.|:  .|...||       .:...||                |:.|.|::..|.|.|
 Worm  2720 MFIEILGVLPSVHY-------MVQVDDG----------------ALWQFQMISQDKRVL------ 2755

  Fly  1070 RKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIAGGIEIFGLHASLVQRRRPPGIPVLEEYV 1134
                                   .::||  :.|   |.|:||             |.|.:.::..
 Worm  2756 -----------------------SNIYV--LKD---AKGLEI-------------PTIRMHKKST 2779

  Fly  1135 FLPFFSSSILSLKNAARVCVQIAIENNPTLKL-KLVEVGAD-GKNHMLTEFIE-AIQDLPVITGD 1196
            .|....:||::.|.     :|:|:.:...|.: .::|.|.| .::.:.|.|.| .|..|..:.
 Worm  2780 LLSSQEASIVAAKT-----LQMAVRHKVCLAVGDVIESGLDIDESQLSTGFSELGIDSLATVD-- 2837

  Fly  1197 YILLTSQNLEDLPGVHIENGSLSTQTNCHIIIIGGYEEDEVHEK-ITSAYNVLVDNGYIVFRQKC 1260
              ||...|.:..|.:.:....|.  .|..||.:....|..::|| ||..
 Worm  2838 --LLNRLNQKYFPEIELTTSDLF--DNPSIIDLSIMIEQLLNEKGITEP---------------- 2882

  Fly  1261 AKNVSCKIAEKFRTISKIPINNTEENLVLLQKISKKLTVPPVLVKVSQHDKTFEWILELQSAIIT 1325
                                  :|.|........:||::|.|..:|....:..|.....|..:..
 Worm  2883 ----------------------SEPNTPKTSLRGRKLSIPAVRAQVLAQIEFVENYNSKQKEVQA 2925

  Fly  1326 KAPVVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDDSAPDFDLSHPFYSTQYSLGLAFNIY 1390
            :||    |.:.:.:..:       :|.|..:.|.......|...|||:....|.:
 Worm  2926 EAP----SSSSECSNHL-------EESDATVDRTEIRRKVSLAVFDLATETLSAE---------- 2969

  Fly  1391 RNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDLSSLQWLKGPFNSQNCHIKIAFSSLNFRDV 1455
                                              ||.|    ||       ..::...||:..|.
 Worm  2970 ----------------------------------DLQS----KG-------FTELGMDSLSIVDF 2989

  Fly  1456 MLATGRLAVELYGSSRIDQNCVLGFEYSGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDW 1520
            :   .||..:.:....|..:.:  |:|..::.|:..     :|:
 Worm  2990 V---NRLNDKYFPDDEITASDI--FDYPTVDELSDH-----IVR--------------------- 3023

  Fly  1521 SLEEAATVPVVYITVYYAFFMATDIRKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTA--- 1582
              :::::||..          |::|.|                          |.....||:
 Worm  3024 --KKSSSVPPA----------ASEIMK--------------------------ETMNGISTSVDA 3050

  Fly  1583 --NKKEFLLKTFPKLKESHIGNSRNTSFELMVHRETNGKGVDFVLNSLSEEKLLASLRCLGKSGH 1645
              .|.|.|.::|..|:..   ||.|.:.:::...:|      ..|...|:...|..|...|  |.
 Worm  3051 EHTKLENLSQSFMLLENQ---NSINPTLKMIWSNQT------IKLVKPSDGNFLFELNANG--GQ 3104

  Fly  1646 FLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLVAPDEDIWHL-KSLIDMDIS--NGIIQPLP 1707
            ..||.|:....:|.|   ..||  .||....::|.::    :.:| ||:..::|.  .|:.|
 Worm  3105 EKEIQKHFTGPNNII---IDLK--GFHEGSTETLYMS----LLNLVKSISKLEIQCRFGVSQ--- 3157

  Fly  1708 VKVFLAHEIEQAFRHLIGGKHIGKVVI----QVREQPHDPSTLPVRVLNQVYFKHNHTYVIPGGL 1768
             :..|.:.|.:||...:..:....:..    .|::.....|..|:          ...::|.|||
 Worm  3158 -EFGLGNSISRAFMKTVAAEKNPLISFAWYQNVQQVSFVDSDSPI----------TGNWLITGGL 3211

  Fly  1769 GGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAISTADITSKKGCAQLLSE 1833
            .|.|:|:..::|..||..::|.|.|..|.. .|.....||:   :|....|||..|:...:.|::
 Worm  3212 SGIGLEIGKFIANNGAENVILISRRQPTAK-ALREFEHWKS---KVHTIAADINDKEKLIRELTK 3272

  Fly  1834 ANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEHFVVFSSVS 1898
            .| :| :.||.:.|.||||.....||...|.:.|.|||.....|:::.:.:..::|:|::.||.:
 Worm  3273 LN-VG-ITGIIHSAGVLKDSKIERQNKESFNQVFTPKANGFHVLEEIEKHFNYKIENFIMMSSFT 3335

  Fly  1899 CGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQR 1963
            ...||.||.|||::|:.:|..::.|.|:|..|.|||||...:.|:..|....|....:|...|..
 Worm  3336 AACGNEGQLNYGVSNAYLEYQVQRRRRQGKSGCAIQWGNWIDTGMATDENVRKFLANLGFLGQHN 3400

  Fly  1964 ------ISSCIQELDHLLCADASIVSSMVVAEKRTMRS------------------------GQG 1998
                  :.:||.....|:.. |:|..::::..::.:..                        ..|
 Worm  3401 KDALKYLRACILTKPELIMV-ANIDWNVILKNRKDLPKDLINTGILPFEDFTGKMNESEFPLSNG 3464

  Fly  1999 NVIDAVMNIMGIRDLKSV------SLSTTL-------------SEMGMDSLMAVEIKQTLERDFE 2044
            :.....|| ..:.|.:.|      .:|:.|             .:||:||.:.||....:...|:
 Worm  3465 DFEKVSMN-FSVEDEEEVLELIKEKVSSILMCSPTKLKNNKNIMDMGLDSKLIVEFLNFINSTFK 3528

  Fly  2045 LILTPQD-LRHLTFQKLQEFI------------DAKEKE---NTD-----GIQIIFASDNKLLGM 2088
            :.:...| ..|.|.:||...|            ..|.:|   :||     ||.|.|  |||
 Worm  3529 ISVNLSDAYNHPTLEKLAAHIFEQMTIVDHPVNSVKSEEIFKSTDFCPIFGINIFF--DNK---- 3587

  Fly  2089 ELLIRNLGDEANCDQIIIPLQTSAAPSKQNLQPNIIIPGLEGTAGR-AWYQLGSKLQSPAIVLQL 2152
                 |..|:|         :::|....:|.:.   :|    |||: |...:|..::..
 Worm  3588 -----NDFDKA---------KSTAVKLLENGEQ---LP----TAGKYAVSVVGKSIRDV------ 3625

  Fly  2153 HQFAHLENLKDVAQQSFDQIKLILKQTEPFYIIAYSYGTFVALLLAEMLEN-SGFRGHLM-LLDG 2215
                 :..:|:.|.|   |||| .:::....::....|:...::..:::|| ..||..|. .|..
 Worm  3626 -----VSKIKEAAPQ---QIKL-CQESSKCVLMLTGQGSQYPMMGRQLVENYEIFRTTLQSCLKK 3681

  Fly  2216 APHFLKRLTNLHLGEQFSDNDLYDLLFSSIVNHIFP 2251
            ...:|:  .::.|.|...:.|.|.||  .:..|:.|
 Worm  3682 CDEYLQ--GDVSLWEILFNTDHYKLL--QLTKHMQP 3713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	196/791 (25%)
		hot_dog	877..1125	CDD:469797	41/257 (16%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	15/109 (14%)
		PKS_ER	1443..1734	CDD:214840	53/298 (18%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	72/232 (31%)
		PKS_PP	2000..2067	CDD:214834	19/98 (19%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	29/135 (21%)
pks-1	NP_508923.2	PKS	13..394	CDD:238429
		KAsynt_C_assoc	<376..>431	CDD:465059
		AcpP	730..803	CDD:440006
		PKS	830..1197	CDD:238429
		hot_dog	1544..1759	CDD:469797
		PKS_PP	<1806..1857	CDD:214834
		PKS	1889..2282	CDD:238429	121/369 (33%)
		PKS_PP	2790..2867	CDD:214834	20/87 (23%)
		PKS_PP	2943..3024	CDD:214834	21/168 (13%)
		PKS_KR	3203..3377	CDD:214833	62/179 (35%)
		AcpP	3485..3549	CDD:440006	14/63 (22%)
		PKS_AT	3649..3927	CDD:214838	16/69 (23%)
		hot_dog	3994..4216	CDD:469797
		PKS	4290..4628	CDD:238429
		KAsynt_C_assoc	<4614..4695	CDD:465059
		Rossmann-fold NAD(P)(+)-binding proteins	<4991..5131	CDD:473865
		AcpP	5167..5235	CDD:440006
		PksD	5256..>6071	CDD:442550
		Rossmann-fold NAD(P)(+)-binding proteins	<6237..6393	CDD:473865
		PRK12316	<6457..>7495	CDD:237054
		A_NRPS_acs4	6987..7412	CDD:341309
		EntF2	<7527..7737	CDD:442548