Protein Alignment FASN3 and Fasn

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: NP_032014.3
• Gene: Fasn / 14104
• MGIID: 95485
• Length: 2504
• Species: Mus musculus
• Alignment Length: 2559
• Identity: 934/2559 - (36%)
• Similarity: 1434/2559 - (56%)
• Gaps: 260/2559 - (10%)

  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFDATFFG 83
            :::||:||:||.|...|:.|:...|...:|||.||:|||:.....:||||||:.||.||||:|||
Mouse     2 EEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFG 66

  Fly    84 VHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGGFG 148
            ||.|||||||||.|:|:|.:|||::|.|:||.||||:.|||::|...||:.:....:..:..|:.
Mouse    67 VHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYS 131

  Fly   149 ITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHPFV 213
            :.||.|||||||:|:....:|||..||||||||:.||.||:.|||:||..||::||.||||.|..
Mouse   132 MVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNT 196

  Fly   214 TLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPEGI 278
            ::||.:||:|:|||.||.||.:.|||.|||.:..:.|.||..|:||||:|:.:.||.||.|.:|:
Mouse   197 SVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGV 261

  Fly   279 TYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGSVK 343
            |:|||.|||:|:...|:.....|..|.|:|||.|||.||||:|...|...||:.|:.|||:||.|
Mouse   262 TFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGSTK 326

  Fly   344 SNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIGIN 408
            ||:||.|.|||:.:|.|...:.|.|:.|||::|......|..|.:|||.||...:|:....:|||
Mouse   327 SNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVGIN 391

  Fly   409 SFGFGGANAHALLKGYPKSKNNFGIPADD----VPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFI 469
            ||||||:|.|.:|:  |.::.   .||..    :|.||..:|||.|||:::.....::..|..|:
Mouse   392 SFGFGGSNVHVILQ--PNTRQ---APAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAFV 451

  Fly   470 GLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSL 534
            .:|.:|.....:.|.||||.:...:|.      .::||..:..:||:.::.||||:||..||.||
Mouse   452 SMLNDIAATPTAAMPFRGYTVLGVEGR------VQEVQQVSTNKRPLWFICSGMGTQWRGMGLSL 510

  Fly   535 MIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPD 599
            |.:..||||:....:.:...|:.:..:|.|.|...:.:|:::||.:.|:||.|.|:|.|:.::||
Mouse   511 MRLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPD 575

  Fly   600 YIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIET 664
            .|||||:||:.|.||||.|:.::.:||||:||:...|.....||||||||.::......|..:..
Mouse   576 GIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVGLSWEECKQRCPAGVVP 640

  Fly   665 ACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHP 729
            ||||..|:.|||||...|.:||..||.:|:|||||....:|:||.::..:.|.||..:.::|..|
Mouse   641 ACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREP 705

  Fly   730 KPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAI 794
            :||:.:|||||:|:..|....|:..||||:.|||::.|||.|....||::::.:|:|||.||.|:
Mouse   706 RPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAV 770

  Fly   795 LKRSMPSG-VHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIR 858
            |||.:.|. ..|||..|.:::|..|||:.|||::|.|:.:....|:..::||..|.||.:|..|:
Mouse   771 LKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIK 835

  Fly   859 WDHSEDWFVTKYENMK--TKSSGERVFSVNLASDN-EEFLSGHIIDGKILVPATCYLQYVWETFS 920
            ||||:.|.|...|:..  :.||...|:|::.:.:: :.:|..|.|||:::.|.|.||..||:|.:
Mouse   836 WDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLA 900

  Fly   921 LMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENP 985
            ... |.|..:.||.||::.|.:||.:|..|.|.|.|.:...:..||:::.|:|:|:|.:...|:|
Mouse   901 RSL-GLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDP 964

  Fly   986 SI-----PEVYNFQSKSKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYNWVT 1045
            :.     |||......:....:.:.:.||||:||||.|...||.:..|..:|..|::.|..||||
Mouse   965 NSKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVT 1029

  Fly  1046 FMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIAGGIE 1110
            |||.|||:.|||:..::|.|||::..:.|:...|...:.::..:.:|.||.........::|||.
Mouse  1030 FMDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIH 1094

  Fly  1111 IFGLHASLVQRRRPPG-IPVLEEYVFLPFFSSSILS---------------------------LK 1147
            |..|..:...||:... :|.||::||.|...:..||                           ||
Mouse  1095 ISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLARALQTKATQQGLK 1159

  Fly  1148 ---------------------------------------------------------NAARVCVQ 1155
                                                                     .|.:.||.
Mouse  1160 AAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQALKACVD 1224

  Fly  1156 IAIENNPTLKLKLVEVGADGKNHMLTEFIEAIQDLPVITGDYILLT--SQNLEDLPGVHIENGSL 1218
            .|:||..|||:|:.||.| |:.|:.:.....:...|::..:|....  .|.|:|          :
Mouse  1225 TALENLSTLKMKVAEVLA-GEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKD----------V 1278

  Fly  1219 STQTNCHIIIIGGYEEDEVHEKITSAYNVLVDN-----------------------GYIVFR--- 1257
            .|:...|.:..|.:...:.......|.::||.|                       |:::..
Mouse  1279 QTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVL 1343

  Fly  1258 --QKCAKNVSCKIAEKFRTISKIPINNTEE-----------NLVLLQK-------ISKKLTVP-- 1300
              ....:.::|..:|    :...|...::|           :||.|::       ...:..:|
Mouse  1344 KGHALGETLACLPSE----VQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGTALFLCRRAIPQE 1404

  Fly  1301 -PVLVKVSQHDKTFEWILELQSAIITKA--PVVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFI 1362
             |:.:.|  .|.:|:|:..|:|.:.|.:  ||.:.:.:...:|.:||||||||||.|:.|||..:
Mouse  1405 KPIFLSV--EDTSFQWVDSLKSTLATSSSQPVWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILL 1467

  Fly  1363 DDDS----APDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQR 1423
            .:.|    ||..|...|.........|..|:||:|:||::||.| |:.|:|.::..|.:.||:.|
Mouse  1468 SNLSNTSHAPKLDPGSPELQQVLKHDLVMNVYRDGAWGAFRHFQ-LEQDKPKEQTAHAFVNVLTR 1531

  Fly  1424 GDLSSLQWLKGPF--------NSQNCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGF 1480
            |||:|::|:..|.        .:|.|  .:.::||||||:|||||:|:.:........::|:||.
Mouse  1532 GDLASIRWVSSPLKHTQPSSSGAQLC--TVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGM 1594

  Fly  1481 EYSGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDI 1545
            |:||.:. .|||:|.:|...|:|:.|...|..:||:|..|:|||||:|||||.|.||:..:...|
Mouse  1595 EFSGRDR-CGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRI 1658

  Fly  1546 RKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFEL 1610
            ::|:::|||:|:||:|.|||.:||:....||||..:|.|:.:|...||:|.::...|||:||||.
Mouse  1659 QRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQ 1723

  Fly  1611 MVHRETNGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVL 1675
            .|...|.|||||.|||||:||||.||:|||.:.|.||||||:|::|::.:|:..|||.:|||.:|
Mouse  1724 HVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGIL 1788

  Fly  1676 ADSLLVAPDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQP 1740
            .|:|....::....:.:|:...|.:|:::||...||...::|.|||::..|||||||::||||:.
Mouse  1789 LDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEE 1853

  Fly  1741 HD---PSTLP--VRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQ 1800
            .:   |...|  :..:::.:...:.:|:|.|||||||:|||.|:.:|||::|:|:|..||...||
Mouse  1854 PEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQ 1918

  Fly  1801 LYRIALWKTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLE 1865
            ...|..|:..|.:|.:||::::|.:|...|::||..:|||||:||||:||:|.:..||....|.:
Mouse  1919 AKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQD 1983

  Fly  1866 CFAPKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPG 1930
            ...||...|..||..:|..||||::||.|||||||||||||:|||.|||.||||.|.|..:|.||
Mouse  1984 VNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLPG 2048

  Fly  1931 KAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKRTMRS 1995
            .|:||||||:||:|.: |....|..|||||.||||||::.||..|....:::||.|:|||:.:..
Mouse  2049 LAVQWGAIGDVGIVLE-AMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAH 2112

  Fly  1996 GQG----NVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLT 2056
            |.|    :::.||.:|:|||||..::|.:||:::|:||||.||::|.|||:.:|:|..:::|.||
Mouse  2113 GDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLT 2177

  Fly  2057 FQKLQEFIDAKEKENTDGIQIIFASDNKLLGMELLIRNLGDEANCDQIII----PLQTSAAPSKQ 2117
            .:|||| :.:|....||.......||..|...:|         |...:::    |..|.....:.
Mouse  2178 LRKLQE-MSSKTDSATDTTAPKSRSDTSLKQNQL---------NLSTLLVNPEGPTLTQLNSVQS 2232

  Fly  2118 NLQPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQIKLILKQTE-P 2181
            :.:|..::..:||:. ..::.|.:||..|...||..|.|.|:::.::|....|.||.:  |.| |
Mouse  2233 SERPLFLVHPIEGST-TVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQV--QPEGP 2294

  Fly  2182 FYIIAYSYGTFVALLLAEMLE----NSGFRGHLMLLDGAPHFLKRLTNLHLGEQ----------- 2231
            :.|..||:|..||..:...|:    .:....:|.|.||:..::...|..:..:.
Mouse  2295 YRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEAEAEAE 2359

  Fly  2232 ---FSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCLSDKMSLFMNYVEK-QNMYSKKYSST 2292
               |......|:..|.::..:.|..|             |.|:::..::.:.| .:...::..|.
Mouse  2360 ALCFFIKQFLDVEHSKVLEALLPLKS-------------LEDRVAASVDLITKSHHSLDRRELSF 2411

  Fly  2293 MVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASL--QDIDEDYCISLLTSGVVTLKVIEGNH 2355
            ...:.:::::.|..:....  |....:||:|......  :|:..||.:|.:..|.|::.:|||:|
Mouse  2412 AAVSFYHKLRAADQYKPKA--KYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDH 2474

  Fly  2356 TTMLDNPSLSQIIDDFDPVLLEDK 2379
            .|:|:...|..||:.....|.|.:
Mouse  2475 RTLLEGSGLESIINIIHSSLAEPR 2498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	368/824 (45%)
		hot_dog	877..1125	CDD:469797	85/253 (34%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	43/115 (37%)
		PKS_ER	1443..1734	CDD:214840	133/290 (46%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	118/226 (52%)
		PKS_PP	2000..2067	CDD:214834	31/66 (47%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	36/163 (22%)
Fasn	NP_032014.3	PksD	1..1353	CDD:442550	506/1373 (37%)
		Acyl and malonyl transferases	429..817		156/393 (40%)
		N-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363	844..967		40/123 (33%)
		C-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363	982..1104		42/121 (35%)
		KR_1_FAS_SDR_x	1311..>1518	CDD:187657	52/213 (24%)
		PKS_ER	1557..1847	CDD:214840	134/292 (46%)
		Enoyl reductase	1628..1856		109/227 (48%)
		Beta-ketoacyl reductase	1857..2111		123/254 (48%)
		KR_1_FAS_SDR_x	<1869..2105	CDD:187657	118/236 (50%)
		PKS_PP	2118..>2173	CDD:214834	24/54 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2181..2205		8/24 (33%)
		Thioesterase	2201..2504		69/325 (21%)
		Thioesterase	2235..2494	CDD:395776	60/276 (22%)