DRSC/TRiP Functional Genomics Resources

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Protein Alignment FASN3 and FASN1

DIOPT Version :10

Sequence 1:NP_001015405.3 Gene:FASN3 / 3355111 FlyBaseID:FBgn0287184 Length:2394 Species:Drosophila melanogaster
Sequence 2:XP_061509638.1 Gene:FASN1 / 1280133 VectorBaseID:AGAMI1_014592 Length:2450 Species:Anopheles gambiae


Alignment Length:2467 Identity:990/2467 - (40%)
Similarity:1432/2467 - (58%) Gaps:171/2467 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKIC--DLEKFDATF 81
            |||.|:|.:|:.|...||.|::..|...:|||:||:|||.....::|.|.|||.  ||.|.||.|
Mosquito    45 DDICITGFSGRLPESSNIEEFKRNLLEGVDMVNDDDRRWPRGLYDLPTRIGKIKDEDLMKLDAEF 109

  Fly    82 FGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGG 146
            |.:|.|||..||||.|:|:|..:||:||:|:||:.:|||:||||||...||:|:.|..:.....|
Mosquito   110 FKIHQKQAECMDPQLRMLLECTHEAIIDAGINPQEIRGSRTGVYIGCSNSETEQHWCADPDLVNG 174

  Fly   147 FGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHP 211
            :|:|||:|||.|||||:....:|||:.:|||||||::||..||:.:|.|..||||:.|..|:|.|
Mosquito   175 YGLTGCARAMFANRISFTFDFKGPSYAVDTACSSSLFALSQAFADMRAGHCDAAIVAGCGLILKP 239

  Fly   212 FVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPE 276
            .::|||.||.:|:.||.|:.||::.:||.||:.....|||:..:::|:|||::..:||.||||.:
Mosquito   240 TMSLQFKRLNMLSKDGMCKAFDESGNGYVRSDGCVVTFLQRAANSRRIYASVLNVRTNTDGYKDQ 304

  Fly   277 GITYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGS 341
            |||||.|.:|::|:.:.|::|...|:|:.|:|||.|||.||||:|..||.:..|..|:.|||:||
Mosquito   305 GITYPIGEMQKRLIRETYEEIGLSPADVTYVEAHGTGTKVGDPQEVNAITDFFCKDRKAPLLIGS 369

  Fly   342 VKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIG 406
            ||||:||||.|||:||:.|...|.|.|:|..|:::....:.:..|.:|||.||...:|.....||
Mosquito   370 VKSNMGHSEPASGVCSIAKILIAMEEGVIPGNLHYNSPNKDLYGLMDGRLKVVDRNLPWNGGIIG 434

  Fly   407 INSFGFGGANAHALLKGYPKSKNNFGIPAD-DVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFIG 470
            :|||||||||||.:||..||.|..  .|.| ..|:|:..:|||.||||...:...|:..|.||:|
Mosquito   435 LNSFGFGGANAHVILKSNPKPKPI--SPKDGGFPKLMVASGRTTEAVEAFLDQAAKSKDDEEFVG 497

  Fly   471 LLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSLM 535
            |:..|...::.....|||.:.|  |.|..:.:.:.::.....:||:.::||||||||..|...||
Mosquito   498 LVNEIHSRNIPLHNHRGYTVVA--GDGQSQTVREVLEVNADEKRPVWFIYSGMGSQWASMAKDLM 560

  Fly   536 IIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPDY 600
            .:..|..|:..|.:.|..:|::||.:||.:|...:.||||||:.|||||:.|||||..:.|.||.
Mosquito   561 QLEVFHNSIYRCAEALRPEGVDLIDVLTKSDETKFDNILNSFISIAAVQVALTDVLTHVGITPDG 625

  Fly   601 IIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIETA 665
            ::||||||||||||||..|.:|.:||||:|||..:|.:.|.|.||||||.::.....|||.:..|
Mosquito   626 MVGHSVGELGCAYADGCFTPEQTVLAAYWRGRSILDTDLIAGQMAAVGLSWEECKQKLPKDVIPA 690

  Fly   666 CHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHPK 730
            |||..||.||||||..|::.:|||..:|||||.|..|.||:||:||:...|.|...::.|||:||
Mosquito   691 CHNSADSVTISGPVSSVSKVIADLNAQGIFAKGVKSSGIAFHSRYIADAAPKLRKSLDRIIPNPK 755

  Fly   731 PRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAIL 795
            .||.:|:|||:|:..|....|:..|:.||.||||:.|||.|....:|.|::.||:||||||.|||
Mosquito   756 NRTPRWISTSIPEESWPTALAQQSSSAYHVNNLLSPVLFAEGLKHVPANAICIEIAPHGLLQAIL 820

  Fly   796 KRSM-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIRW 859
            ||:: ....::.|..|.:.||..|.||.|||:|.:|.......||..|.:||.|.||.::||::|
Mosquito   821 KRALGKDATNLSLMKRDHANNMIFLLSNLGKLYSSGAQPQVQKLYRPITYPVGRGTPMLNSLVKW 885

  Fly   860 DHSEDWFVTK--YENMKTKSSGERVFSVNLASDNEEFLSGHIIDGKILVPATCYLQYVWETFSLM 922
            |||.:||:.|  .||    .|||.:..|||..|::.:|:||.|||::|.|||.||...|.|::.|
Mosquito   886 DHSINWFLAKIGVEN----KSGETIIDVNLGKDDDAYLAGHTIDGRVLFPATGYLTLAWRTYAKM 946

  Fly   923 YHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTG---IIRETEN 984
             .|......||..|:..|.|||.:|.||.|...:....|||.|||.|.|:|.|:|   |..:.|.
Mosquito   947 -QGADIEKTPVVIENAVFHRATILPKDGSVKFGINFFDGTGAFEICEGGTLAVSGKLTIPEKIEQ 1010

  Fly   985 PSIPEVYNFQSKSKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDG--LFGRVQWNYNWVTFM 1047
            ..:|.......||..| :...|.||||:||||.|...|:.|  .||||  :.|.:||..|||:||
Mosquito  1011 EELPLNKLEADKSGLP-LNMSDVYKELRLRGYDYADMFRGV--TRSDGRAITGELQWRDNWVSFM 1072

  Fly  1048 DAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDP--ENRVFDVYVDPMYDRIIAGGIE 1110
            |.|||..|||.|.|.|.|||:|.|:.||...|.:::..:..  ::|...||:....:.|.:||:|
Mosquito  1073 DTMLQFSILGKDLRELYLPTRIEKIVINPARHLEMVANLTQTGDDRTLPVYMYREINVIKSGGVE 1137

  Fly  1111 IFGLHASLVQRRR-PPGIPVLEEYVFLPFFSSSILSLKN-------AARVCVQIAIENNP-TLKL 1166
            :.||.|:|..||: ....|.||:|||:|..:...|:..|       |....|.:.|||:. .||:
Mosquito  1138 MRGLRATLAPRRQGTQAPPTLEKYVFVPNANEKELAEGNSEKARLRAITAAVHLVIENSAGALKI 1202

  Fly  1167 KLVEVGAD--GKNHMLTEFIEAIQDLPVITGDYILLTSQNLEDL------PGVHIENGSLST--- 1220
            |:.|...:  .:|.|.......|:..|.:..|..:.|:...:.|      .||.:.:..::.   
Mosquito  1203 KVAEASFERSPENTMAGTVQAIIEGEPTLASDVAVATTHQPDSLVQHYGESGVRVLSKDVAAGAI 1267

  Fly  1221 QTNCHIIIIGGYEE----------DEVHEKITSAYNVLVDNGYIVFRQKCAKNVSCKIAEKFRTI 1275
            :.|||:.|  ||:.          ..:.:.|.:...||::.....|..:|               
Mosquito  1268 EQNCHLAI--GYDTFGRADPDTILRNLRDSIKAEGFVLLEESRSTFDARC--------------- 1315

  Fly  1276 SKIPINNTEENLVLLQKISKK--LTVPPVLVKVSQH--------DKTFEWILELQSAI----ITK 1326
             :..:......||..|...||  :.|.|.:.:::|.        :::|.|:.||::|:    .|.
Mosquito  1316 -RAALVKAGFTLVSTQVCEKKVFVLVRPTIAELAQRKSVVIALTERSFGWVEELKAALAKAEATS 1379

  Fly  1327 APVVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDDSAPDFDLSHPFYSTQYSLGLAFNIYR 1391
            ..|.:....|:|.|..||:||::.|..|...|.:||.|..|..|.|:...|..|.:..|..|:.|
Mosquito  1380 TYVYIVCQGEELCGAQGLMNCVKNEVGGKFARLYFIQDRKADKFSLTGAMYKEQLAKDLICNVLR 1444

  Fly  1392 --NG----SWGSYRHLQL-LKNDQPSKRLDHIYGNVIQRGDLSSLQWLKGPFNSQNCHIK----- 1444
              ||    :||::|||:| .:::.||..::|.|.|.:.:|||:||:|::...:.:...:.     
Mosquito  1445 PANGTPAPAWGTFRHLRLDSQSNAPSLPVEHAYINALTKGDLASLKWIESSLSRERPDLSARDAR 1509

  Fly  1445 -----IAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEYSGINMLTGRRIMSMVVKGGVAS 1504
                 :.::.:|||||||::|:|..:........|:|:||.|::|.:. .|||||:||....:|:
Mosquito  1510 TELCTVYYAPINFRDVMLSSGKLGADALPGDLATQDCILGLEFAGRDS-NGRRIMAMVQAKSLAT 1573

  Fly  1505 YVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRKGKSILIHAGTGGIGLAAIRVAL 1569
            .......:||:|||.|::|:|:|||.||.|||||..|...:::|:|||||||:||:|.|||.|||
Mosquito  1574 TCVAQRNMIWEIPDGWTMEQASTVPCVYSTVYYALVMRGRMKRGESILIHAGSGGVGQAAISVAL 1638

  Fly  1570 AYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMVHRETNGKGVDFVLNSLSEEKLL 1634
            |..:.|:||..:..|:|||.:|||:|.:.:|||||:.|||.:|.|||.|:|||.|||||:||||.
Mosquito  1639 AAGVTVYTTVGSKEKREFLKRTFPQLTDRNIGNSRDCSFEQLVMRETQGRGVDLVLNSLAEEKLQ 1703

  Fly  1635 ASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLVAPDEDIWHLKSLIDMDIS 1699
            ||:||||.:|.||||||:|:.|::.:|:..|||..:||.:|.||::...||.|..:..|:...|.
Mosquito  1704 ASIRCLGLNGRFLEIGKFDLNNNSPLGMSVFLKNTSFHGILLDSVMEGDDETIAEVVKLVADGIK 1768

  Fly  1700 NGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPH----DPSTLPVRVLNQVYFKHNH 1760
            :|.::|||..||...::|||||.:..||||||||::|||:..    .|:...:..:.:.|.....
Mosquito  1769 SGAVRPLPTSVFTEQQVEQAFRFMASGKHIGKVVVRVREEEKAKIVQPAPKLISAIPRTYMHAEK 1833

  Fly  1761 TYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAISTADITSKK 1825
            .|::.|||||||:||::|:..|||:.::|:|..|:...||...|..|...|.:|.|.|.|:|:.|
Mosquito  1834 VYILIGGLGGFGLELSNWLVSRGAKIIVLTSRSGVRTGYQSLMIRRWTERGVKVVIDTNDVTTLK 1898

  Fly  1826 GCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEH 1890
            |..:||::|...|||||:||||.||:|.:..|.....|.....||...|..||..:|..||||::
Mosquito  1899 GAQKLLTDAARHGPVGGVFNLAAVLRDGLLENSTEADFRAVCVPKVDGTKNLDLATRELCPELDY 1963

  Fly  1891 FVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDME 1955
            |:.||||||||||.||.|||:|||.||||.|.|:..|.|..||||||||:.|||.:...|. |..
Mosquito  1964 FICFSSVSCGRGNQGQVNYGLANSAMERICEARHAVGLPATAIQWGAIGDTGLVLENLGDN-DTV 2027

  Fly  1956 IGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKRTMRSGQGNVIDAVMNIMGIRDLKSVSLST 2020
            :||||.||:.||:|.:|..:...:.:::|||:||||...:|..:::..:.||:|::|.|:||...
Mosquito  2028 VGGTLPQRMPSCLQTMDLFMQQPSPVLASMVIAEKRKTDTGGVSLVGCIANILGLKDTKNVSDGA 2092

  Fly  2021 TLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQKLQEF-------------------IDA 2066
            ||:::||||||..||||||||.|:|:|:..::|.|||.||:.|                   ..|
Mosquito  2093 TLADLGMDSLMGAEIKQTLERSFDLVLSAAEIRLLTFGKLRSFEKGGAAAAGDVGAAAGGSPAAA 2157

  Fly  2067 KEKENT--DGIQIIFASDNKLLGMELLIRNLGDEANCDQIIIPLQTSAAPSKQNLQPNIIIPGLE 2129
            ...||.  ||.|:.|:::  |:..|.|:|               ..||||:....:|...:..:|
Mosquito  2158 AASENAIGDGTQVKFSAE--LMPKECLVR---------------MESAAPAGSKARPVFAVHAIE 2205

  Fly  2130 GTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQIKLILKQTEPFYIIAYSYGTFVA 2194
            |.. .|...|...|..|...||..:.|.||:|..:|.....||:.: :...|:.|:.||:|..:|
Mosquito  2206 GVI-TALIPLAQTLPVPVYGLQCDEAAPLESLVLLAGYYIKQIRTV-QPRGPYTIVGYSFGASIA 2268

  Fly  2195 LLLAEMLENSGFRGHLMLLDGAPHFLKRLTNLHL-----GEQF-SDNDLYDLLFSSIV--NHIFP 2251
            ..:...||.:|....|:|:||:|.::...|....     ||.. ::::.|.|.:.::|  :..:.
Mosquito  2269 YEMVAQLEKAGDTCQLLLVDGSPRYVSWYTEAQKQRNANGEVVQAEDEAYALAYFAMVCGSLDYG 2333

  Fly  2252 EASKESMSTVFHQVDCLSDKMSLFMNYVE-KQNMYSKKYSSTMVKAMFNRVKMAASFDLDGIIKI 2315
            ..:||.:     :.....::::.....|. |...||.|..:|..|:...  |:.||.......||
Mosquito  2334 RTAKELV-----EAKSWEERVAKCAEMVHAKAPQYSLKLLATTAKSFVG--KIVASHMYKPASKI 2391

  Fly  2316 KSPITLVRPAE--ASLQDIDEDYCISLLTSGVVTLKVIEGNHTTMLDNPSLSQIIDDFDPVL 2375
            |:.:.||:|.|  |.||.   ||.:|.|....|.|..:||:|.:||...|:.:|.|....:|
Mosquito  2392 KATVKLVKPTENYAKLQG---DYGLSDLCQQKVELFTVEGDHRSMLLGDSMKKISDVLQKLL 2450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN3NP_001015405.3 PksD 16..>839 CDD:442550 388/823 (47%)
hot_dog 877..1125 CDD:469797 106/255 (42%)
Rossmann-fold NAD(P)(+)-binding proteins <1301..>1411 CDD:473865 39/128 (30%)
PKS_ER 1443..1734 CDD:214840 143/300 (48%)
KR_1_FAS_SDR_x <1761..1988 CDD:187657 109/226 (48%)
PKS_PP 2000..2067 CDD:214834 33/85 (39%)
alpha/beta hydrolases 2120..>2265 CDD:473884 38/152 (25%)
FASN1XP_061509638.1 None

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