DRSC/TRiP Functional Genomics Resources

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Protein Alignment FASN3 and LOC1277512

DIOPT Version :10

Sequence 1:NP_001015405.3 Gene:FASN3 / 3355111 FlyBaseID:FBgn0287184 Length:2394 Species:Drosophila melanogaster
Sequence 2:XP_061518498.1 Gene:LOC1277512 / 1277512 VectorBaseID:AGAMI1_013887 Length:2268 Species:Anopheles gambiae


Alignment Length:2380 Identity:1058/2380 - (44%)
Similarity:1463/2380 - (61%) Gaps:164/2380 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PDTDGDDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFD 78
            |.|..|.|||||:|||:|...::..:...||||:|:|||.|.||||....||||.||:..|.|||
Mosquito    25 PITADDSIVISGIAGKYPRSDSVEHFADNLYNKVDLVDDKEDRWRHLYAGIPKRLGKLNKLGKFD 89

  Fly    79 ATFFGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVS 143
            |.|||..|::.||||||.|:|:|..|||::|:|::|..:||::|||::|..|:|:|..|.|:|..
Mosquito    90 AEFFGSGFQETHTMDPQQRLLLEHCYEALLDAGLHPDDIRGTRTGVFVGVSIAETEIYWTYKKTK 154

  Fly   144 SG-GFGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNL 207
            |. ...|.|..|:|:|.:|:|.|.|:|||..:||||||||||||.|..|||.|:.||||:.|:||
Mosquito   155 SPYNRSILGFVRSMLATKIAYALDLKGPSMAVDTACSSSMYALDWACKAIRQGQCDAAIVAGTNL 219

  Fly   208 LLHPFVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDG 272
            .|||::|||||.|||||.||:|||||||||||:|||....:.|||.|.|||:||.:|.:||||||
Mosquito   220 TLHPYITLQFALLGVLAADGYCRPFDKNASGYSRSEANAVILLQKAKDAKRIYAHVVNTKTNCDG 284

  Fly   273 YKPEGITYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPL 337
            ||.||||:||..:|::|||:.|.::.:.|.|:.|:|||||||||||||||.||:.|.|..|.|||
Mosquito   285 YKLEGITFPSNKIQKQLLDELYSEVPYDPKDISYVEAHSTGTVVGDPEECDAIEKVFCPDRTEPL 349

  Fly   338 LVGSVKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPK 402
            ||||||||:||||||:||||:.|...|.:..:|.||||:||.:..:..|..|:|.||....||..
Mosquito   350 LVGSVKSNIGHSEAAAGICSVTKCVIAMQNRIIPPNINYTEPRTDVPSLLNGKLKVVDQCTPLGG 414

  Fly   403 PYIGINSFGFGGANAHALLKGYPKSKNNFGIPADDVPRLLTWAGRTEEAVEEIFNAVEKNPLDAE 467
            |.:.:||||||||||||||....|.|.|.|.|.|.:|||:.|:|||.|||:...::::....|||
Mosquito   415 PLVAVNSFGFGGANAHALLHNCTKQKINGGYPKDGLPRLVVWSGRTIEAVDHFLDSLKGKSYDAE 479

  Fly   468 FIGLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQ---RPIVWVYSGMGSQWNQ 529
            |..|..|||..::..|..:|||||..:..|..:||.|...:....:   .|:...:..:...|..
Mosquito   480 FYALTHNIQRSEIPKMTTKGYAIFGGRQDGTAELLYKAASNKIPKKYKLPPVTLAFGQLEGNWKA 544

  Fly   530 MGNSLMIIPRFRESVEICHQILLAKGLNLI-HILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRS 593
            ...:....|.|...:..|.|.:...|.:.. ..:.:|||  .|:||.:|:    .|:|:..:|.:
Mosquito   545 TVQAFNQFPEFANGIAECLQAIKDCGFDAFDQTMQANDP--IQHILWTFM----AQVGVYRLLTA 603

  Fly   594 LNIQPDYIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHML 658
            ..:..|...|::||::.|||.||.|:....:..||..|.:      ||                 
Mosquito   604 SGVTIDQYAGYAVGQITCAYLDGVLSLHDALRVAYAHGYI------IR----------------- 645

  Fly   659 PKSIETACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMN 723
                   .|:...|......|....|....|.|.                     :.|..|    
Mosquito   646 -------AHHTEKSANYGSGVSSNKQLTVKLATA---------------------LKPLRL---- 678

  Fly   724 EIIPHPKPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPH 788
                  :..|.||.:....| .:.....|..:..:||...      :|...|.|.|: :.:|..|
Mosquito   679 ------QAATPKWFNPCQLK-TFEMYDPKVMTTLFHTLGA------NEAIVLQPLNA-SKDVLMH 729

  Fly   789 GLLGAILKRSMPSGVHIPLTNRGNQNNASFFLSALGKIYLNG---VLLPAANLYERIQFPVSRTT 850
                                          ||.:||:::|.|   .|||   :|..||||||:.|
Mosquito   730 ------------------------------FLKSLGEVFLKGHPVNLLP---VYPTIQFPVSQGT 761

  Fly   851 PSVSSLIRWDHSEDWFVTKYENMKTKSSGERVFSVNLASDNEEFLSGHIIDGKILVPATCYLQYV 915
            ..:|||:.||||.||.||.:...:........::::|:  .::::|||.|||:||:|||.||.||
Mosquito   762 GMISSLLEWDHSADWHVTNFRTTRMVDQSTSEYTISLS--EQDYISGHCIDGRILIPATGYLFYV 824

  Fly   916 WETFSLMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIR 980
            |::||... |....::||||.||.|:|||::..|.:|.|||.::..||.||::|..:|||.|.|:
Mosquito   825 WDSFSGRM-GIIPEEMPVEFSDIEFLRATTLVGDQQVTLTVDLNEVTGSFEVSEGTALVVKGRIQ 888

  Fly   981 ETENPSIPEVYNFQSKSKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYNWVT 1045
            ...|.:.||..:.||.:  .|:..|||||||:||||||.|.|::|..:|:||.:.:::|.|||..
Mosquito   889 ALTNYTPPETKHRQSDA--VMMPSKDFYKELRLRGYHYGGYFKSVMESRTDGSYAKIEWKYNWTA 951

  Fly  1046 FMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRV--FDVYVDPMYDRIIAGG 1108
            .:|.:||:.|:..|||:|::||:|..:||:.:.|  .:|.....|.|  ::|..||..:.:..|.
Mosquito   952 LLDCILQVAIIAVDSRSLVIPTRIESIKIDPIQH--KLTDQATGNEVPSYNVCFDPDLNLLQCGA 1014

  Fly  1109 IEIFGLHASLVQRRRPPGIPVLEEYVFLPFFSSSILSLKNAARVCVQIAIENNPTLKLKLVEVGA 1173
            |||.||:||.:.||.|||:||||.|.|.|::....::..:|....||..:||..|:...:.|:.:
Mosquito  1015 IEIRGLNASTIARRLPPGVPVLESYKFHPYYPQHTMAPSSAVSTIVQTILENQATIFFTVTEIHS 1079

  Fly  1174 DGKNHMLTEFIEAIQDLPVITGDYILLTSQNLEDLPGVHIENGSLSTQTNCHIIIIGGYEEDEVH 1238
            ..|:.:::.|.:||.|||::.....||::...|.:|.|.|....|..|.|..::|......|:  
Mosquito  1080 KTKDPIISLFGDAIGDLPLVKAHLTLLSTAKPEPIPNVTISEDKLMKQRNVLLLICENLFADD-- 1142

  Fly  1239 EKITSAYNVLVDNGYIVFRQKCAKNVSCKIAEKFRTISKIPINNTE-ENLVLLQ--KISKKLTVP 1300
            |.|:.|.|.|.|.|:|:.|:    :...::.:..|.:..:...:.| |..:|||  |.:...:|.
Mosquito  1143 EFISDAINCLSDQGFILLRE----SPEYRLQDGHRRLQLVSTMSIEGETFLLLQQKKSAMNTSVD 1203

  Fly  1301 PVLVKVSQHDKTFEWILELQSAIITKAPVVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDD 1365
            ..::||..:|.|..|:|||:..:.|| ||::|:.|::.:|.||||||:||||:...:.||||||.
Mosquito  1204 AHVIKVCSNDTTHNWLLELKQEVKTK-PVILYAQNDRSSGIIGLVNCIRKEPNIQTVSCFFIDDP 1267

  Fly  1366 SAPDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDLSSLQ 1430
            :||.||.|:|||..|..||||.|:||.|.||||||.:|.:..:......|.:.|.::.|||||..
Mosquito  1268 TAPAFDASNPFYKEQIELGLAINVYREGQWGSYRHFKLQEEPRYEPATKHCFANCVKPGDLSSFT 1332

  Fly  1431 WLKGPFNSQ---NCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEYSGINMLTGRR 1492
            |:.||.:.|   :...::.:|||||:|||:|||||.||.:.:.|:.|.|:|||||||:. .||:|
Mosquito  1333 WMVGPLSEQPPSSPLARVVYSSLNFKDVMIATGRLTVETFCTDRLQQECILGFEYSGVT-TTGKR 1396

  Fly  1493 IMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRKGKSILIHAGT 1557
            :|.::..|.:|:.||.......|:||:.|||:|||:|.||.|||.:||:...||||.||||||||
Mosquito  1397 VMGIIGAGSMATIVETDPIFTLDVPDNISLEQAATIPTVYTTVYASFFVCAQIRKGNSILIHAGT 1461

  Fly  1558 GGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMVHRETNGKGVD 1622
            ||:|||||||.|||.||||||.||..|::|||..||.|..::|||||:.|||.::...|||:|||
Mosquito  1462 GGVGLAAIRVCLAYGLEVFTTVSTKEKRDFLLSYFPDLNPNNIGNSRDISFETLIKERTNGRGVD 1526

  Fly  1623 FVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLVAPDEDI 1687
            |||||||||||.||:|||.:.|||||||||||..|:||.:..|.:.|||.|||.|.|.....:.:
Mosquito  1527 FVLNSLSEEKLQASIRCLARGGHFLEIGKYDMMKDSKIAMTFFQRGITFTAVLVDLLFQEKRDLL 1591

  Fly  1688 WHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPHDPSTLPVRVLN 1752
            ..|..||..|::.|||||||..||.|||||||||:|...|||||||:::|:...|.:::|:..|.
Mosquito  1592 VELHKLIMKDLAKGIIQPLPTTVFQAHEIEQAFRYLATAKHIGKVVLKIRDNEDDLASVPISYLP 1656

  Fly  1753 QVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAIS 1817
            :||.....|:||.|||||||:|||||:.|||.|||||||||||||.||.|||..|:|||.:|.:|
Mosquito  1657 RVYCNPEQTFVIAGGLGGFGLELADWLIIRGCRKLLLSSSRGITKPYQQYRINTWRTYGVQVTVS 1721

  Fly  1818 TADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSR 1882
            |.||::..||.:||.:|..|||:.|||||||.|:|.|..||:|::|.||.||||.||.:||.|||
Mosquito  1722 TEDISTYDGCRRLLQQAIQMGPIAGIFNLAVQLRDAIIENQSVDKFAECLAPKATATHHLDALSR 1786

  Fly  1883 IYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADM 1947
            ..||.|:|||||||||||||||||||||||||:||||||||...|.||||||||||||||:||||
Mosquito  1787 ELCPMLKHFVVFSSVSCGRGNAGQSNYGMANSIMERIIEHRVVHGLPGKAIQWGAIGEVGIVADM 1851

  Fly  1948 AEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKRTMRSGQGNVIDAVMNIMGIRD 2012
            .|||||||||||||||:|||||.||.||.....||:||||||||:...|..|:::||||||.|||
Mosquito  1852 QEDKIDMEIGGTLQQRLSSCIQVLDQLLTTSEPIVASMVVAEKRSSSGGAKNIVEAVMNIMNIRD 1916

  Fly  2013 LKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQKLQEFIDAKEKENTDGIQI 2077
            :||||:.:||:::||||||||||:|.|||||::||||||||.|||.|||:..|||.:..|     
Mosquito  1917 MKSVSVESTLADIGMDSLMAVEIRQVLERDFDIILTPQDLRTLTFSKLQKLADAKTESET----- 1976

  Fly  2078 IFASDNKLLGMELLIRNLGDEANCDQIIIPLQTSAAPSKQN----LQPNIIIPGLEGTAGRAWYQ 2138
             ..:..:.|.::.|:.:.|||......::.|     |||.|    .:|.:||||:|..:..||.:
Mosquito  1977 -AEATTQQLQLQDLLASFGDETASHHTVLRL-----PSKCNDLEYDRPVLIIPGIESVSSPAWTK 2035

  Fly  2139 LGSKLQSPAIVLQLHQFA---HLENLKDVAQQSFDQI-KLILKQTEPFYIIAYSYGTFVALLLAE 2199
            :.|::.:|..|||  .||   ..:.:..:....|::: :.:..:.|.|.:|.||:|..:||.:.:
Mosquito  2036 IASEINAPTFVLQ--TFAKGSDEQTIPGIVDSVFEEMFETVFAKAEQFLVIGYSFGALLALEVVK 2098

  Fly  2200 MLENSGFRGHLMLLDGAPHFLKRLTNLHLGEQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQ 2264
            .||....||.|||:||:|.:|:|..:.|| ..|.|..|...:.:.::....|..|.|.:|::..:
Mosquito  2099 RLEARPLRGKLMLIDGSPLYLQRFASHHL-SGFDDEHLQMAILTLVLRFSLPSVSNEILSSIMGE 2162

  Fly  2265 VDCLSDKMSLFMNYVEKQNMYSKKYSSTMVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASL 2329
            . ...::::..::...:.|.:|::|:..|::.:..|:|.|.:...:...|:.||:.|||  ..::
Mosquito  2163 A-TYENRVTKMLDIGRESNPFSEEYTRKMMRVLLFRLKAAMNMSTEVKEKLASPLVLVR--SGTI 2224

  Fly  2330 QDIDEDYCISLLTSGVVTLKVIEGNHTTMLDNPSLSQIID 2369
            .||:|||.::..||..:.:|:|:|.|.|||.|..|.:||:
Mosquito  2225 GDIEEDYGLTEFTSSSMIVKIIDGTHQTMLANMELLEIIN 2264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN3NP_001015405.3 PksD 16..>839 CDD:442550 332/830 (40%)
hot_dog 877..1125 CDD:469797 104/249 (42%)
Rossmann-fold NAD(P)(+)-binding proteins <1301..>1411 CDD:473865 55/109 (50%)
PKS_ER 1443..1734 CDD:214840 171/290 (59%)
KR_1_FAS_SDR_x <1761..1988 CDD:187657 164/226 (73%)
PKS_PP 2000..2067 CDD:214834 46/66 (70%)
alpha/beta hydrolases 2120..>2265 CDD:473884 45/148 (30%)
LOC1277512XP_061518498.1 None

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