Protein Alignment FASN3 and FASN2

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: NP_001259986.1
• Gene: FASN2 / 117361
• FlyBaseID: FBgn0042627
• Length: 2410
• Species: Drosophila melanogaster
• Alignment Length: 2491
• Identity: 976/2491 - (39%)
• Similarity: 1429/2491 - (57%)
• Gaps: 215/2491 - (8%)

  Fly     4 TKNKKYSRSFPDTDGDDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRS 68
            ::.|....|....|. ||||||::||.|...||.|::|.|.|.||||.|:.|||......:|:|.
  Fly     3 SRKKAQGESAAGEDA-DIVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERM 66

  Fly    69 GKI--CDLEKFDATFFGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCIS 131
            .|:  .||||||..||.||.|||..|||..|:|:|..:||:||:|:||..||||:||||||....
  Fly    67 AKMKDSDLEKFDDKFFSVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRGSRTGVYIGLSFV 131

  Fly   132 ESE-KTWFYEKVSSGGFGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNG 195
            |:| :....|..|..|:.:|||:|||.||||||....:||||::|||||||:.||::||:.:|.|
  Fly   132 ETEHEIPNMEPSSINGYCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVALNHAFADMRAG 196

  Fly   196 EIDAAIIGGSNLLLHPFVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVY 260
            ..|.|::.|.||:|.|...|||.|||:::.||.|:.||..|:||.|::|...:.||::|.|||||
  Fly   197 RCDYALVAGVNLILKPIFALQFLRLGIVSHDGSCKTFDAAANGYARADTCAVVLLQRRKEAKRVY 261

  Fly   261 ASIVYSKTNCDGYKPEGITYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAI 325
            |||:..:||.||:|.:|:|:|.|.:|:.||::.|.:|...|.::.|:|||.:||.|||.:|...:
  Fly   262 ASILNVRTNTDGFKEQGVTFPDGRMQQALLEETYSEIGLNPDEVVYVEAHGSGTPVGDDQEANML 326

  Fly   326 DNVLC-SQREEPLLVGSVKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEG 389
            .|..| ..|..|||:||||||:||:|.|||:.:|.|...|.|.|:|..|:::......:..|.||
  Fly   327 SNFFCRPSRSTPLLIGSVKSNMGHAEPASGVSALAKMIIAMEEGIIPKNLHYRTPNPSVPALVEG 391

  Fly   390 RLIVVKDVVPLPKPYIGINSFGFGGANAHALLKGYPKSKNNFGIP----ADDVPRLLTWAGRTEE 450
            :|.||...:|.....:|:|||||||||||.:||.:.|:|.....|    |:....|:|.:||||:
  Fly   392 KLKVVDRNLPWQGGIVGLNSFGFGGANAHVVLKSHTKAKEPKACPKAGEAEQSLSLVTCSGRTED 456

  Fly   451 AVEEIFNAVEKNPLDAEFIGLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRP 515
            ||.::.....:...|.|.:.|:.:|....:....|||||:.   ||..|  :.::|..|...:||
  Fly   457 AVNQLLKVATEQRHDQELLTLINDIHSHPIPLHPFRGYAVL---GTSGC--VKEEVLPYEEEERP 516

  Fly   516 IVWVYSGMGSQWNQMGNSLMIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGI 580
            |.:||:||||||.:|...||.:..||.|::.|.::|.....:||.:||.:....:.|:|.|||.:
  Fly   517 IWFVYAGMGSQWARMAKDLMQLEVFRNSIQHCAEVLAQVDFDLIDVLTRSTERTFDNMLYSFVSV 581

  Fly   581 AAVQIGLTDVLRSLNIQPDYIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKI-RGSM 644
            :|||:.|||:||.|:|:||.|||||.||||.||.||.|||:|.:||||:|||..:|...: ||.|
  Fly   582 SAVQVALTDLLRVLDIRPDGIIGHSAGELGAAYMDGCLTAEQTVLAAYWRGRSVLDTPDLPRGKM 646

  Fly   645 AAVGLGYKTVLHMLPKSIETACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSK 709
            |||||.::.:...:||.....|||..|:||:|||...:...:.||..||||.:||.....|:||.
  Fly   647 AAVGLSWEQIGSQIPKDCYPVCHNSDDNCTVSGPPSSMDAMIEDLTAKGIFVREVGSGGYAFHSP 711

  Fly   710 YISHMGPPLLNYMNEIIPHPKPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFS 774
            ||....|.|...:..:|..||.::.:||||||.:.:|:.:|....||.|..|||::.|||.:...
  Fly   712 YIEGAAPMLRRSLERLITEPKKKSIRWLSTSVKEAEWDSEKNHLASAGYFINNLISPVLFHQAVK 776

  Fly   775 LIPKNSLTIEVAPHGLLGAILKRSMPSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLY 839
            .||:|:|.:|:|||||..|||:...|...::.|..||:.||..|.||.||::|..|.......:.
  Fly   777 RIPQNALIVEIAPHGLFRAILRSLSPQISYVSLMQRGHANNFEFLLSQLGRLYAAGGQPQILKIS 841

  Fly   840 ERIQFPVSRTTPSVSSLIRWDHSEDWFVTKYENMKTKSSGERVFSVNLASDNEEFLSGHIIDGKI 904
            ..|.:||||.||.:.||:.|||::.|...|::.  .:.:|:....::|..:...:|:||.|||::
  Fly   842 PSIPYPVSRGTPMLGSLVGWDHTQKWNYPKFKG--GRQAGQLSVELDLGKEENVYLAGHTIDGRV 904

  Fly   905 LVPATCYLQYVWETFSLMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITE 969
            |.|||.|:...|.:.: ...|..|:..||.|||:.|.|||.:.|...|.||:....|:..|||.|
  Fly   905 LFPATGYMTLAWMSLA-QQQGLDYLRTPVLFEDVVFHRATILSVGTVVKLTLNFFPGSSSFEICE 968

  Fly   970 MGSLVVTGIIRETENPSIPEVYNFQSKSKFPMIA------KKDFYKELKLRGYHYNGAFQAVNLA 1028
            ..|||.:|.||...|....::    ..|..|.||      .||.||||:||||.|.|.||.:..:
  Fly   969 GTSLVTSGKIRLVSNVQQEQL----QLSSLPGIAGSNKLSTKDIYKELRLRGYDYTGVFQGILES 1029

  Fly  1029 RSDGLFGRVQWNYNWVTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPE---- 1089
            ....:.|::||..||::|||.|||.:||..|.|.|.:||.|.:..|:.:.|.:|..|...:
  Fly  1030 DISAVTGQLQWADNWISFMDTMLQFRILSNDIRELYVPTGIERALIDPLKHLELAKKHQQKLTVN 1094

  Fly  1090 -NRVFDVYVDPMYDRIIAGGIEIFGLHASLVQRR---RPPGIPVLEEYVFLPFFSSSIL------ 1144
             :|...|        :..||:||..:..:..|||   :.|  |.||.|.|.|  .|..|
  Fly  1095 WHRNISV--------VKCGGVEIHKMKTAQTQRRSGGQSP--PSLERYRFWP--HSQHLGQREEQ 1147

  Fly  1145 --SLKNAARVCVQIAIENN-PTLKLKLVEVGADGKNHML-----TEFIEAIQDLPVITGDYILLT 1201
              |...|..|.:|:.|||: ..:|||.||:.  |....|     .:.:|.|:..|::.||..::|
  Fly  1148 EKSRSTALAVAIQLIIENSGGAVKLKGVELA--GSRSTLDALSAVQLLELIEREPILVGDMAVVT 1210

  Fly  1202 SQNLEDLPGVHIENGSL----------STQTNCHIII-IGGYEEDEVHEKITSAYNVLVDNGYIV 1255
            |.:.|...|..::...:          :.:..||.:. :....::.|.:......::..|:|:::
  Fly  1211 SSSNESELGEQLKEHGIRVIVKDIKAGAVEQQCHFVYSVNMLAQNSVKDLQHCLDSLKSDSGFLL 1275

  Fly  1256 FRQKCAKNVSCKIAEKFRTISKIPIN------------NTEENLVLLQKISKKLTVPPVLVKVSQ 1308
            ..:         .|.::..|.|..:|            .|:..|||::|:||        |:.||
  Fly  1276 LEE---------AASRYNIIGKEKLNKLKLVSVLEQFFGTDRVLVLVRKLSK--------VQSSQ 1323

  Fly  1309 ----H--DKTFEWILELQSAIITKAP-----VVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFI 1362
                |  :|.|:|:.||::: |.||.     :.:.:..|..:|.:||:|||::|..|:.:|.:.|
  Fly  1324 ALTLHLTNKQFKWVNELKNS-IAKAQAEEKNLYLVAQGEPNSGALGLMNCLKREAGGHFLRLYLI 1387

  Fly  1363 DDDSAPDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDLS 1427
            .|:..|.|.|..|||:.|.:..|..|:||||||||||||: :::..|...::..|.|.:.:||||
  Fly  1388 LDEGVPQFSLDDPFYAAQLAKDLVVNVYRNGSWGSYRHLK-MESRPPMLPVEQAYVNTLVKGDLS 1451

  Fly  1428 SLQWLKGPFNS------QNCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEYSGIN 1486
            ||:|::.|.:|      :.|  .:.::.|||||||||:|:|.|:........|:||||.|::|.:
  Fly  1452 SLRWIESPRSSPIQSQLEPC--TVYYAPLNFRDVMLASGKLGVDALPGDLAYQDCVLGLEFAGRD 1514

  Fly  1487 MLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRKGKSI 1551
            . .|||:|:||....:|:.......|:|::|..|::|:|:|||.||.|||||..:...:::|:.|
  Fly  1515 S-CGRRVMAMVTAKSLATNCLANRNLLWEVPSKWTMEQASTVPCVYATVYYALVVRGQMKEGERI 1578

  Fly  1552 LIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMVHRET 1616
            |||||:||:|.|||.||||:.|.||||..:..|:|||||.|||||..:|||||:||||.::..||
  Fly  1579 LIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLKAKNIGNSRDTSFEQLIMSET 1643

  Fly  1617 NGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLV 1681
            :|.||:.||||||||||.||:|||..:|.||||||:|::|:..:|:..|||..:||.:|.||::.
  Fly  1644 HGNGVELVLNSLSEEKLQASIRCLALNGRFLEIGKFDLSNNTPLGMSVFLKNTSFHGILLDSVME 1708

  Fly  1682 APDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPHDPSTL 1746
            ..:|....:..|:...|.:|.:||||..||...|||:|||.:..|||||||||:||.:....:.|
  Fly  1709 GEEEMQLMVAKLVAEGIKSGAVQPLPTTVFAEQEIEKAFRFMASGKHIGKVVIKVRLEEEQQAAL 1773

  Fly  1747 P----VRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALW 1807
            |    ::.:.:.|.....:|::.|||||||:|||:|:..||||.|:|||..|:...||...|..|
  Fly  1774 PRLRQIQAIPRSYMHPEKSYILVGGLGGFGLELANWLVSRGARFLVLSSRSGVKSGYQALMIRRW 1838

  Fly  1808 KTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAI 1872
            ...|.:|.|.|.|:|:..||.:||..:|.:..||||||||.||:|.:..:|:...|.:..|||.:
  Fly  1839 HDRGVQVQIDTNDVTTAVGCQRLLEVSNKLALVGGIFNLAAVLRDGLIEDQSPKNFEKVSAPKLL 1903

  Fly  1873 ATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGA 1937
            ||.:||.:||..||.||:||.|||:||||||.||:|||:|||.||||.|.|...|:||.||||||
  Fly  1904 ATIHLDKISREICPALEYFVCFSSLSCGRGNMGQTNYGLANSTMERICEQRQEYGYPGTAIQWGA 1968

  Fly  1938 IGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKR-TMRSGQGNVI 2001
            ||:.||:.:...:. :..:||||.||:.||::.||..|.....:::|||||||| |.::.:.::|
  Fly  1969 IGDTGLIIEHMGNN-ETVVGGTLPQRMISCLETLDLFLQQPHPVMASMVVAEKRKTEQANRLSLI 2032

  Fly  2002 DAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQKLQEFIDA 2066
            ..:.||||:||:||||..|||.::||||||:.||||||||.|:|:|:.|::|.|||..|:: |||
  Fly  2033 ATIANIMGLRDVKSVSDKTTLFDLGMDSLMSTEIKQTLERHFDLVLSAQEIRQLTFSALRQ-IDA 2096

  Fly  2067 KE------------------KE--------NTDGIQIIFASDNKLLGMELLIRNLGDEANCDQII 2105
            :|                  ||        .:|..:.:||.:  :|..|:::|
  Fly  2097 QEPPSASVSSPSASSTLSRIKEEACVEVQPQSDETRKVFAKE--VLPQEVMVR------------ 2147

  Fly  2106 IPLQTSAAPSKQNLQPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFD 2170
              |::.|..:.::.....:.| :||.. .|...|.:.|..||..||..:...|::::..|.....
  Fly  2148 --LRSKAPVASEDPAVFFLAP-IEGFT-IAVEALAASLTCPAYGLQCTEQVPLDSIEACAAYYLR 2208

  Fly  2171 QIKLILKQTEPFYIIAYSYGTFVALLLAEMLENSGFRGHLMLLDGAPHF--------------LK 2221
            ||:. |:...|::|:.||||..:|..:|..||...|...:::|||||..              |.
  Fly  2209 QIQK-LQPLGPYHIVGYSYGCLLAHAIAVALEQRRFGVKVIMLDGAPTMASGYVQEAKKQTDDLN 2272

  Fly  2222 R---LTNLHLGEQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCLSDKMSLFMNYVEKQN 2283
            |   :|..:.|...:|.|...:|...:          :.:.|...::|.|:|.::   .|.::..
  Fly  2273 RQQSMTLAYFGALLADVDYNQVLLQLL----------DGVQTWPSKLDKLADTLA---GYTQQTR 2324

  Fly  2284 MYSKKYSSTMVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASLQDIDEDYCISLLTSGVVTL 2348
            ...||     ...||.: |:..|....|..::.|.:.|::.||.: ..:.:||.:..:.|..:.:
  Fly  2325 EVIKK-----AACMFKQ-KLLLSESYKGAKQLHSDVVLIKSAEHN-AIMAQDYGLKEICSAQIDM 2382

  Fly  2349 KVIEGNHTTMLDNPSLSQIID 2369
            .|:||.|.|.|..|...|||:
  Fly  2383 HVVEGTHRTFLKEPHTLQIIE 2403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	373/831 (45%)
		hot_dog	877..1125	CDD:469797	91/261 (35%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	46/120 (38%)
		PKS_ER	1443..1734	CDD:214840	145/290 (50%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	114/226 (50%)
		PKS_PP	2000..2067	CDD:214834	39/66 (59%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	39/161 (24%)
FASN2	NP_001259986.1	PksD	15..>832	CDD:442550	372/822 (45%)
		hot_dog	894..>1072	CDD:469797	76/182 (42%)
		Rossmann-fold NAD(P)(+)-binding proteins	1263..>1429	CDD:473865	58/184 (32%)
		PKS_ER	1471..1761	CDD:214840	146/292 (50%)
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657	115/238 (48%)
		PKS_PP	2031..>2083	CDD:214834	32/51 (63%)
		EntF2	<2159..2409	CDD:442548	67/268 (25%)