Protein Alignment FASN3 and fasn

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: XP_031750124.1
• Gene: fasn / 100487052
• XenbaseID: XB-GENE-1002983
• Length: 2510
• Species: Xenopus tropicalis
• Alignment Length: 2581
• Identity: 956/2581 - (37%)
• Similarity: 1430/2581 - (55%)
• Gaps: 298/2581 - (11%)

  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFDATFFG 83
            :||||:||:|:.|...|:.|:...|...:|||.:|:|||:.....:|||:||:.:|:||||.|||
 Frog     2 EDIVIAGMSGRLPESNNLQEFWDNLIQGVDMVTEDDRRWKPGLYGLPKRNGKLKELDKFDAAFFG 66

  Fly    84 VHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGGFG 148
            ||.|||||||||.|:|:|..|||::|:|:||..|||:.|||::|...||:.:.:..:.....|:.
 Frog    67 VHPKQAHTMDPQLRLLLEICYEAIVDAGINPNELRGTNTGVWVGVSGSEAGEAFSRDPEELLGYS 131

  Fly   149 ITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHPFV 213
            :|||.|||.||||||....:|||..:|||||||:.||:||:.||::|:.:|||:.|.|:||.|..
 Frog   132 MTGCQRAMFANRISYFFNFKGPSLSIDTACSSSLLALENAYKAIQHGQCNAAIVAGVNVLLKPNT 196

  Fly   214 TLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPEGI 278
            ::||.:||:|:|||.|:.||.:.:||.|||....:.:.||..|||:|::|:.:.:|.||:|.:|:
 Frog   197 SVQFMKLGMLSPDGACKSFDASGNGYCRSEAAVAVLVTKKSLAKRLYSTILNAGSNTDGFKEQGV 261

  Fly   279 TYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGSVK 343
            |:|||.||::||...||:....||.:.|||||.|||.||||:|...|..|||....||||:||.|
 Frog   262 TFPSGAVQQELLTSLYKEAGIHPSQVEYLEAHGTGTKVGDPQEVNGIVGVLCDSTREPLLIGSTK 326

  Fly   344 SNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIGIN 408
            ||:||.|.|||:.:|.|...:.|.|:.|||:::......|..|.:||:.||....|:....:|||
 Frog   327 SNMGHPEPASGLAALAKVILSLEHGVWAPNLHYETPNSDIPALQDGRIQVVTKPTPVKGGIVGIN 391

  Fly   409 SFGFGGANAHALLKGYPKSKNNFGIPADDVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFIGLLQ 473
            ||||||:|.|.:||  |..|....:.:.:.|||:...||||:|||.|.....:...|..|:.||.
 Frog   392 SFGFGGSNVHIILK--PNEKKPSDVASVEFPRLVLACGRTEKAVESIIQKSREPAADNTFVTLLN 454

  Fly   474 NIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSLMIIP 538
            :|.....|.|.:|||.: ||..:.     .|::|......||:.::.||||:||..||:|||.:.
 Frog   455 DISGIPQSSMPYRGYTL-AKTDSD-----IKEIQQAQVSGRPLWYICSGMGTQWKGMGHSLMKLD 513

  Fly   539 RFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPDYIIG 603
            .||:|:....:.|...||.:..:|.:.|...:::.|::|||:||:|:...|:|:::.::||.|:|
 Frog   514 IFRQSILRSDEALKGTGLKVSELLLNADDRTFEDTLHAFVGLAAIQVAQIDMLKAMKLEPDGIVG 578

  Fly   604 HSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIETACHN 668
            ||||||.|.|||..|:..:.|||||:|||...:.....|.||||||.:.......||.:..||||
 Frog   579 HSVGELACGYADNSLSQNEAILAAYWRGRCIKEAHLPPGGMAAVGLTWAECKIQCPKGVVPACHN 643

  Fly   669 GPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHPKPRT 733
            ..|:.|||||.|.|.:||..||:||:|||||..:.:|:||.|:..:.|.|||.:.:||. ||||:
 Frog   644 SEDTVTISGPQDSVREFVGSLKSKGVFAKEVQSAGVAFHSYYMESIAPSLLNALKKIIT-PKPRS 707

  Fly   734 KKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAILKRS 798
            .:|:|||:|:..||.:.|||.|||||.|||::.|||.|....||:|::.:|:|||.||.|:|:||
 Frog   708 SRWVSTSIPESQWNSNLAKFSSAEYHVNNLVSPVLFQEGLQNIPENAVVVEIAPHALLQAVLRRS 772

  Fly   799 M-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIRWDHS 862
            : |:...:||..:|:.||..|||:.:||:|:||:.:.|.|::..:::|....|..:|.||.||||
 Frog   773 LKPTNTILPLMKKGHSNNLEFFLTNIGKVYMNGINVEANNIFPSVEYPAPAGTSLISPLIMWDHS 837

  Fly   863 EDWFVTKYENMKTKSSGE---RVFSVNLASDNEE-FLSGHIIDGKILVPATCYLQYVWETFSLMY 923
            :.|.|.|.|:....|.|.   .|:::::..|:.: |::||.|||::|.|||.||...|.|.:...
 Frog   838 QTWDVPKAEDFPAGSGGSTATTVYNIDMNPDSPDLFMNGHCIDGRVLYPATGYLVLAWRTLARSL 902

  Fly   924 HGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENPSIP 988
             |......||.|||:...|||.:|..|.:.:.|.:...:..||::|.|||..:|.|...|...:
 Frog   903 -GIVMEQTPVIFEDVTIHRATILPKTGIIQMEVRLMPASKRFEVSENGSLTASGKISVMEENVL- 965

  Fly   989 EVYNFQSK------------SKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNY 1041
              .|||::            |:.| ::.:|.||||:||||.|..:||.:..:.|.|..|::.|:.
 Frog   966 --NNFQNQLMDSLDKDEDIDSELP-LSDRDIYKELRLRGYDYGPSFQGIIESNSRGDKGKLLWSG 1027

  Fly  1042 NWVTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIA 1106
            |||||.|.|||:.:||...|:|.|||:|..:.|:...|.|.:...:.:.....|.|:...|||:|
 Frog  1028 NWVTFTDTMLQMMVLGLKGRSLRLPTRILSVGIDPTIHKDHVFLHNGDREAVHVAVNSCLDRIVA 1092

  Fly  1107 GGIEIFGLHASLVQRRRPPGI-PVLEEYVFLPFFSSSILS------------------------- 1145
            ||::|.||||:...||:.... |:||::||.|:|....||
 Frog  1093 GGVQILGLHATTAPRRQQQQTPPILEKFVFTPYFEEKCLSDNHDLHYQLQQCSGKIRDLESKLSQ 1157

  Fly  1146 -----------------------------------------------------------LKN--- 1148
                                                                       |:|
 Frog  1158 HGLKLEIPEFNVPEPTNEGTKSDALNKGLLHVLTEICNLELNGNLQSDLELMLIKEKDQLRNDPL 1222

  Fly  1149 --------AARVCVQIAIENNPTLKLKLVEVGAD-GKNHMLTEFIEAIQDL-PVITGDYI----- 1198
                    ..:.|:.|.:||....::|:|||.|: |:   |..::..:.:. |::..|||
 Frog  1223 LNGLLDSPQLKTCLDIVLENGNPQQMKIVEVLAETGR---LFSYVPTLLNTQPMLQLDYIATDST 1284

  Fly  1199 ----LLTSQNLEDLPGVHIEN----GSL-STQTNCHIIIIGGYEEDEVH------EKITSAYNVL 1248
                |...:||::. ||.:|.    |:. :|.||..:::.    ...:|      :..|:....:
 Frog  1285 TEVLLSLEENLKEF-GVSVEQWDPLGTAPNTVTNADLLVC----NSSLHLLKNPLQAFTNMAATV 1344

  Fly  1249 VDNGYIVFRQKCAKNVSCKIAEKFRTISKIPINNTEENLVLLQK--------------ISKKLT- 1298
            .:.|:|:.......::   :.|   ||:.:...|.::|..||.:              |:.|.:
 Frog  1345 KEGGFILLHTLLKGDM---LGE---TITFLNNQNPQQNEGLLSQTEWKEVFDGASLNLIAMKKSF 1403

  Fly  1299 -----------VP---PVLVKVSQHDKTFEWILELQSAIITKAPVVVY--SFNEKLNGQIGLVNC 1347
                       ||   |:.:.|  .|....|:..:|.|:.......::  :.|:..:|.:|:|||
 Frog  1404 YNSVIFLCRRQVPEQTPLFLSV--EDMACTWVKSVQEAMADSGEQTIWFVAENQANSGTVGMVNC 1466

  Fly  1348 LRKEPDGNLIRCFF-IDDDSAPDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSK 1411
            ||:||.|..|||.| .|.::.|   ||......|.:..|..|:||:|.|||:||:...| |....
 Frog  1467 LRQEPGGKRIRCIFNADAEAKP---LSEKEKKQQLTNDLVMNVYRDGEWGSFRHIPFHK-DGIQD 1527

  Fly  1412 RLDHIYGNVIQRGDLSSLQWLKGPF--------NSQNCHIKIAFSSLNFRDVMLATGRLAVELYG 1468
            .....:.|::.|||||:|.|:..|.        |.|.|  |:.::||||||:|||||:|..:...
 Frog  1528 ETAFAFVNILTRGDLSTLSWVASPLQHFLPSNPNVQLC--KVYYASLNFRDIMLATGKLPPDAIP 1590

  Fly  1469 SSRIDQNCVLGFEYSGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYI 1533
            .....|.|:||.|:||.:. .|:|:|.::...|:|:.|:...:.:||:|:.|||||||:|||||.
 Frog  1591 GDLALQQCMLGMEFSGRDP-AGKRVMGLLPAKGLATAVDADQRFLWDVPESWSLEEAASVPVVYA 1654

  Fly  1534 TVYYAFFMATDIRKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKES 1598
            |.|||..:...||||:|:|||:|:||:|.|||.:||:...:||.|..::.|:|:|...|.:|..:
 Frog  1655 TAYYALVVRGRIRKGESVLIHSGSGGVGQAAIAIALSMGCQVFITVGSSQKREYLQNRFTELDAN 1719

  Fly  1599 HIGNSRNTSFELMVHRETNGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLG 1663
            ...|||:||||..:...|.|||||.:||||:||||.||||||.:.|.||||||||::|::.:|:.
 Frog  1720 CFANSRDTSFEQHILSRTGGKGVDLILNSLAEEKLQASLRCLARHGRFLEIGKYDLSNNSPLGMA 1784

  Fly  1664 CFLKEITFHAVLADSLLVAPDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKH 1728
            .|||.::||.:|.|:|....:::...:..|:...|.:|:::||...||...::|.|||.:..|||
 Frog  1785 LFLKNVSFHGILLDALFEDQNKEWEEVSDLLKAGIKDGVVKPLKCTVFERDDVEPAFRFMAQGKH 1849

  Fly  1729 IGKVVIQVR----EQPHDPSTLPVRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLL 1789
            ||||:|:||    ||.:....|.:..:.:..|....:|:|.|||||||:|||.|:..|||:.|:|
 Frog  1850 IGKVLIKVRDEEAEQHYKSDILQISAIPRTSFPSTKSYIITGGLGGFGLELAQWLIERGAKNLVL 1914

  Fly  1790 SSSRGITKDYQLYRIALWKTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCI 1854
            :|..|:...||..:|..||..|.:|.:|..|:.|.:...||:.||..:||||||||||:||||.:
 Frog  1915 TSRSGVRNGYQAKQIQTWKGMGIKVLVSGKDVGSLEETLQLIEEAGQLGPVGGIFNLAMVLKDAM 1979

  Fly  1855 FSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERI 1919
            ..|.....|.:...||...|..||.:||..||||:|||.|||||||||||||||||.|||.||||
 Frog  1980 IENLTTQLFQDVNKPKYDGTLNLDRVSREKCPELDHFVAFSSVSCGRGNAGQSNYGFANSTMERI 2044

  Fly  1920 IEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSS 1984
            .|.|.|:..||.|:||||||:||:|.:..... |..|||||.|||.||::.||..|.....::||
 Frog  2045 CEKRRRDNLPGLAVQWGAIGDVGVVLETMGSN-DTVIGGTLPQRIVSCMEVLDQFLNQPHPVMSS 2108

  Fly  1985 MVVAEK----RTMRSGQGNVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFEL 2045
            .|:|||    ::..|.|.::::||.:|:|:||:.|::..|||:::|:||||.||::||||||:::
 Frog  2109 FVLAEKTLSVKSKGSSQQDLVEAVAHILGVRDINSLNPDTTLADLGLDSLMGVEVRQTLERDYDI 2173

  Fly  2046 ILTPQDLRHLTFQKLQEFI-------DAKEKENTDGIQIIFASDNKLLGMELLIRNLGDEANCDQ 2103
            ::..:::|.||..||:|..       |||..:.:.            :..||.|.:|      ..
 Frog  2174 VMAMREVRQLTINKLRELSSKPSTMEDAKSTQKSS------------VPPELSILDL------TN 2220

  Fly  2104 IIIPLQTSAAPSKQNLQ----PNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDV 2164
            :::....|......|::    |..::..:||:.. |::.|.|||..|...||..:.|.|:::..:
 Frog  2221 LLVNPDASTTTKLNNVETDERPLFLVHPIEGSTA-AFHSLASKLAIPCYGLQCTRAAPLDSIYSL 2284

  Fly  2165 AQQSFDQIKLILKQTE-PFYIIAYSYGTFVALLLAEML----ENSGFRGHLMLLDGAPHFLKRLT 2224
            |......||.|  |.| |:.|..||:|..||..:...|    |.|.....|.|.||:..::...|
 Frog  2285 ASYYNQCIKQI--QPEGPYLIAGYSFGACVAFEMCSQLQAQREASQAPDSLFLFDGSHSYVAAYT 2347

  Fly  2225 NLHLGEQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQ---------VDCLSDKMSLFMNYVE 2280
            ..:..:....::              .||..|::.....|         |:.|.....|....:.
 Frog  2348 QSYRAKLTPGSE--------------AEAETEALCAFIQQFTGMEYNKLVEALLPLKDLESRVIS 2398

  Fly  2281 KQNMYSKKYSSTMVKAM-------FNRVKMAASFDLDGII---KIKSPITLVRPAEASL--QDID 2333
            ..|:.::.:.....:|:       |.::|.|     |..|   |.:..:||:|....:.  :.:.
 Frog  2399 AVNLITQSHKDISQEALQFAASSFFYKLKAA-----DQYIPKNKYQGNVTLLRAKTRTEYGEGLG 2458

  Fly  2334 EDYCISLLTSGVVTLKVIEGNHTTMLDNPSLSQIIDDFDPVLLEDK 2379
            .||.:|.:..|.|::.||||:|.|.|:...:..||......|.|.:
 Frog  2459 IDYRLSEVCDGKVSVHVIEGDHRTFLEGTGVDSIIGIIHSSLAEPR 2504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	375/820 (46%)
		hot_dog	877..1125	CDD:469797	95/263 (36%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	38/112 (34%)
		PKS_ER	1443..1734	CDD:214840	134/290 (46%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	120/226 (53%)
		PKS_PP	2000..2067	CDD:214834	30/73 (41%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	38/162 (23%)
fasn	XP_031750124.1	PksD	1..>815	CDD:442550	375/821 (46%)
		hot_dog	871..1111	CDD:469797	91/244 (37%)
		Methyltransf_12	1251..1350	CDD:400515	23/106 (22%)
		Rossmann-fold NAD(P)(+)-binding proteins	1326..>1519	CDD:473865	51/203 (25%)
		PKS_ER	1565..1855	CDD:214840	135/292 (46%)
		KR_1_FAS_SDR_x	<1853..2112	CDD:187657	128/259 (49%)
		PKS_PP	2125..>2180	CDD:214834	24/54 (44%)
		Thioesterase	2241..2500	CDD:395776	66/280 (24%)