Protein Alignment FASN3 and fasn2

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: XP_073801445.1
• Gene: fasn2 / 100000781
• ZFINID: ZDB-GENE-041210-242
• Length: 2106
• Species: Danio rerio
• Alignment Length: 2334
• Identity: 520/2334 - (22%)
• Similarity: 900/2334 - (38%)
• Gaps: 542/2334 - (23%)

  Fly    17 DGDDIVISGMAGKFPNCRNITEYQYKLY---NKIDMVDDDE---RRWRHFNPEIPKRSGK----- 70
            |..:|.|.|:...||....:..:...|.   |....:.:|.   .:|  ::|| ..::||
Zfish     4 DDTEIAIVGVGCHFPGGEGLENFWRVLLEGKNCAVQIPNDRFNLSQW--YDPE-ESKAGKTYTAK 65

  Fly    71 ---ICDLEKFDATFFGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIG----- 127
               |..|..||..|||:...::.:||||.::|::..|.|:.|:|:..:...|::||||:|
Zfish    66 AALIDGLNAFDHKFFGITEAESLSMDPQHKLLLQCTYRALEDAGIPMEKASGTRTGVYLGLMNRD 130

  Fly   128 ---SCISESEKTWFYEKVSSGGFGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAF 189
               :.:..:.|   :...::|    ||.:.::.||||||.....|||..:|.|||||:.||..|.
Zfish   131 FELATVRNNPK---HISHTTG----TGVAMSIAANRISYIFNFTGPSVAIDCACSSSLVALHFAC 188

  Fly   190 SAIRNGEIDAAIIGGSNLLLHPFVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKK 254
            .||:.|:.|.::.||.:.:|.|.:.:..::..:::|||..:||...|.||.|.|....:.|:..|
Zfish   189 QAIKQGDCDMSVCGGVSCILEPALFVALSKAKMISPDGTSKPFSSKADGYGRGEGCGVVLLKPLK 253

  Fly   255 HAKRVYASI--VYSKT--NCDGYKPEGITYPSGIVQEKLLDQFYKDIDHKPSDL---GYLEAHST 312
            .|...:..|  |..||  |.||:....||.||.:.||:||.:.|.    ..:||   .|:|||.|
Zfish   254 RALEDHDHIWGVIGKTAVNQDGHSVSPITKPSMVQQEELLRKIYS----TEADLCSVQYIEAHGT 314

  Fly   313 GTVVGDPEECKAIDNVLC---SQREEPLLVGSVKSNVGHSEAASGICSLVKACFAFETGLIAP-- 372
            ||.||||.|..::..|:.   ||:..||::||||||:||:|:|:|:..|:|.....:...|.|
Zfish   315 GTPVGDPVEAGSMSKVIAKERSQKSGPLIIGSVKSNIGHTESAAGVAGLIKVLLMMQHETIVPSL 379

  Fly   373 --------------NINF-TEVKQIIAPLAEGRLIVVKDVVPLPKPYIGINSFGFGGANAHALLK 422
                          |:|. |.|::.|:....||:             .|||:|||||.||||::|
Zfish   380 FYSKENSSIDLKSLNMNIPTRVQKWISNNRAGRI-------------AGINNFGFGGTNAHAIVK 431

  Fly   423 GYPKSKNNFGIPADDVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFIGLLQNIQEEDVSGMVFRG 487
            .|.:||.....|.....:....:..:|:::..|.    ::..|....|.:.::|....:....|.
Zfish   432 QYVQSKKPKSQPISKSCQYFVVSAASEKSMRNII----RDTADQIGAGKISDLQSLLYTSACRRS 492

  Fly   488 YAIFAKQGTGPCKLLAKDVQH-----------YTGLQRPIVWVYSGMGSQWNQMGNSLMIIPR-F 540
            :.....:.......|| |:|.           .:.....:|:|:.|.|..:..|...|:.... |
Zfish   493 HLKHKYRNAFQTSSLA-DLQDKLTAAVDKRLVLSKTDSRVVFVFCGNGVTYQGMCQQLLKHETVF 556

  Fly   541 RESVEICHQIL-LAKGLNLIHILTS--------NDPEVYQNILNSFVGIAAVQIGLTDVLRSLNI 596
            ||.:.....:| :.:..|||.:|..        :||::.|.:|      .|:|:.:..:|:...|
Zfish   557 REEIVKIETLLKIYRRQNLIEMLEGRSEMSKDLSDPQLVQPLL------FAIQVAVFKLLKHWGI 615

  Fly   597 QPDYIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAV-GLGYKTVLHMLPK 660
            .||.::|||:||:..|:..|.|:.:..:...:||.  |:......|.|..| .:....:|:|||.
Zfish   616 SPDAVLGHSIGEVAAAHCSGLLSLEDAVKVIHYRS--SLQSTVTGGKMLVVSNMAVSEILNMLPS 678

  Fly   661 SIETAC---HNGPDSCTISGPVDDVAQFVADLKT----KGIFAK--EVPCSNIAYHSKYISHMGP 716
            .....|   :|.|.|||:||...::......|.:    |.:|.:  :||.   |||    |||..
Zfish   679 HSGRVCLAAYNSPQSCTLSGDAAEIDSLHQKLSSSTNGKDLFLRILDVPA---AYH----SHMMD 736

  Fly   717 PLLNYMNEIIPHPKPRTKKWLSTSVPKIDWNKD-----------KAKFCSAEYHTNNLLNSVLFD 770
            |:::.:.|.|            .|:...|...:           ...|.:.||...|:..:|.|:
Zfish   737 PIVSRVKEDI------------GSLQTCDLEMELFSTVTGVSSCSTDFITGEYWARNIRQAVEFE 789

  Fly   771 ETFSLIPKNS---LTIEVAPHGLLGAILKRSMPSGVHIPLTNRGNQNNASFFLSALGKIYLNGVL 832
            :......||.   :.:|:.|...|...:..::...:.:....:.::::.: .|:.:.|::..|..
Zfish   790 QAVKSATKNKRNVIFVEIGPRRSLQRYITETLGKDIAVVPAVQPDKDHET-MLAVVSKLFELGAN 853

  Fly   833 LPAANLY-----ERIQFP--------------------VSRTTPSVSSLIRWDHSEDWFVTKYEN 872
            :.....|     |.|.||                    .:|..|.|:                 .
Zfish   854 INWDLFYKGWEAEPIPFPRYQFDDVKREVFASDLQLTGTTRNHPVVT-----------------Q 901

  Fly   873 MKTKSSGERVFSVNLASDNEEFLSGHIIDGKILVPATCYLQYVWETF---------------SLM 922
            |.|.||   |||.:|:|::..||..|..:|..::|...|.:....||               |:.
Zfish   902 MSTDSS---VFSCDLSSESVAFLQDHKHNGVAIIPGAFYTELGLATFMEYAKPKVPLSSLQLSIT 963

  Fly   923 YHGP-----SYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRET 982
            :..|     :...:.|:.|::    |.||. :.|:..|..: |..|..|       |..|...|.
Zfish   964 FQSPLTFTQNAPHIKVQLENL----ADSMH-NFKIHSTSAV-YAFGSVE-------VQPGRRPEE 1015

  Fly   983 ENPSIPEVYNFQSKSKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYNWVTFM 1047
            :..|:..:    |:.....:..::|||:|...|:.|...|:    .::|
Zfish  1016 QFISLDSI----SRRCTLHMTSEEFYKQLSQTGFQYGSVFR----NKAD---------------- 1056

  Fly  1048 DAMLQIQILGTDSRNLLLPTKIRKLKINGVHHF-------DLMTKMDPENRVFDVYVDPMYDRII 1105
                  ...|.:.|..|...|:.|..::.:|.:       |...::.|.....|....|.:...|
Zfish  1057 ------VYCGEEFREALSVVKVPKELLHQLHDYHLHPVVLDYFMQLAPVTLGNDQSARPQFPAQI 1115

  Fly  1106 AGGIEIFGLHASLVQRRRPPGIPVLEEYVFLPFFSSSILSLKNAARVCVQIAIENNPTLKLKLVE 1170
            | .:.:|.              |:.||.|                             :.|:.|:
Zfish  1116 A-SLTVFE--------------PLQEELV-----------------------------VYLRAVD 1136

  Fly  1171 VGADG----------KNHMLTEF----IEAIQDLPVITGDYILLTSQNLEDLPGVHIENGSLSTQ 1221
            ||.||          :..:|.|.    |:.|.....:..:|....|.::..      |:..|.||
Zfish  1137 VGDDGFEICGCLANKQGRVLVEIKHVKIKMIGSRSEVVKEYFFHNSFDIIS------EDDMLDTQ 1195

  Fly  1222 TNCHIIIIGGYEEDEVHEKITSAYNVLVDNGYIVFRQKCA--KNVSCKIAEKFRT-ISKIPINNT 1283
            ....:.      .|::  .|..|....:|:     |.:|.  .:.|..:.....| :||:.|::.
Zfish  1196 IKALVF------SDQL--GIFKALQQHLDS-----RSRCVSFSDSSTLLEGGVETLLSKLAISSV 1247

  Fly  1284 EENL--VLLQKISKKLTV---PPVLVKVS----QHDKTFEWILELQSAIITKAPVVVYSFNEKLN 1339
            ::|.  :|.......||.   ..||..::    ...||..::..||...:.:  |:.|..:|.:.
Zfish  1248 KKNFQEILFMWSDADLTTLESEKVLESMAGCCEMFRKTVRYLKALQFPGVIR--VITYRSSESIV 1310

  Fly  1340 GQI-------GLVNCLRKEPDGNLIRCFF--IDDDSAPDFDL--------SHPFYSTQYSLGLAF 1387
            ..|       |:......|    |....|  ||..|....|:        |:|.:.....:....
Zfish  1311 DSINPGYVLTGMTRACAAE----LQELSFQLIDMGSGTSEDIKALVQVLRSYPCHKYPELVVKEG 1371

  Fly  1388 NIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGN---VIQRGD------LS------SLQWLKGPFN 1437
            ||.:    ....|..|.....|.::: |:...   ::|..|      ||      |:|.::|  .
Zfish  1372 NILQ----PEITHTPLPSMASPLQKV-HMLDEELFILQTSDPYAMRNLSATEMENSIQPIQG--K 1429

  Fly  1438 SQNCHI-KIAFSSLNFRDVMLATGRLAVELYGSSRIDQ-NCVLGFEYSGINMLTGRRIMSMVVKG 1500
            ....|: ||...|.::..|.::.......||.:....| :.:|..:|||.....|:.:....|..
Zfish  1430 HVELHLNKICVHSSDYFPVSMSDLSYGHTLYWNKHTSQHHNLLALDYSGTVTAVGKDVSKFKVGD 1494

  Fly  1501 GVASY--VEKPSKLIW---------------DIPD------DWSLEEAATVPVVYITVYYAFFMA 1542
            .|.|.  |...||::.               |||.      .|.:...| :|.:.:......|..
Zfish  1495 HVVSCYPVSATSKVVIPAAVCCKAKRLSFLNDIPCVSYMVLAWEILHKA-LPKIKVQRKLGIFST 1558

  Fly  1543 TDIRKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTS 1607
            ..    .|.||:.      |.||.....:|::|.|      :.:.|...|.::    :|......
Zfish  1559 VP----DSALINV------LLAIANRSGWNVKVCT------QTDQLSCDFSEV----VGAVFLPP 1603

  Fly  1608 FELMVHRETNG-KGVD---FVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKE 1668
            :.|:.....:. ||::   ||.::.:|..|        .|..|....                :|
Zfish  1604 YNLVTAEVASRIKGINDIVFVCDNQTEVPL--------NSATFRSTN----------------EE 1644

  Fly  1669 ITFHAVLADSLLVAPDEDIWHLKSLI---------------DMDISNGIIQP--------LPVKV 1710
            :.||.|....:|     ..|.|::.:               .|.:....:|.        |.||
Zfish  1645 VHFHFVFMSQVL-----QKWSLQTQMPKIYRWQKSMHLNRKSMSLDTTAVQRANSQHIDLLSVK- 1703

  Fly  1711 FLAHEIEQAFRHLIGGKHIGKVVIQVREQPHDPSTLPVRVLNQVYFKHNHTYVIPGGLGGFGMEL 1775
                |.:..|.     ..|..::|...|..:..|.:||...|.: ||....|::.|||.|.|.|.
Zfish  1704 ----ESDSYFT-----CQILPIIILNSEDKNQLSEIPVIPKNNL-FKKKSVYIVTGGLTGLGFET 1758

  Fly  1776 ADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAISTADITSKKGCAQLLSEANGM--- 1837
            ..::|.:|...:::.|.|....:.|.....|....|..:.....|::..:...|.:::...:
Zfish  1759 VKFIAQKGGEHIVILSRRNPNPEMQQEISQLSSRCGSVIKSLPCDVSVSEQVDQTIAKVKKLFPS 1823

  Fly  1838 GPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRG 1902
            .|:.|:|:.||||.|.:....:.:.:.:...||......| ..:.|.| .|::||.:||:|...|
Zfish  1824 SPIKGVFHSAVVLHDGLIERLDKSLYEKVMRPKVNGVINL-HRATIQC-NLDYFVCYSSISAFMG 1886

  Fly  1903 NAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSC 1967
            ||.|:||..||:.|:...::|...|..|::|.|||: .:||:.|....:..:|..|.|...:...
Zfish  1887 NASQTNYAAANTFMDTFCQYRRNIGLAGQSINWGAL-NLGLLLDKVHFQRFLEAKGILLLEVPEI 1950

  Fly  1968 IQELDHLLCADASIVSSMVVAEKRTMRSGQGNVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMA 2032
            .:.|:..|.    |.....|..:.:.::...:|:.           ::.||:..|.::..::.:.
Zfish  1951 HESLEQCLL----INKPQQVVCRFSFKNSWNSVLS-----------QNKSLNARLFKIAKEAFIR 2000

  Fly  2033 VEIKQTLERDFELILTPQD-LRHLTFQKLQEFIDAKEKENTDGIQIIFASDNKLLGMEL 2090
            ..:..:.........:|.| ||.|    :.|....::.|.:|.:.:.....:.:|.|.|
Zfish  2001 AGVNPSRPEQPMTSSSPHDYLRFL----ISETAGVEKDELSDDVHLFELGIDSMLAMTL 2055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	243/915 (27%)
		hot_dog	877..1125	CDD:469797	53/274 (19%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	25/130 (19%)
		PKS_ER	1443..1734	CDD:214840	61/342 (18%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	60/229 (26%)
		PKS_PP	2000..2067	CDD:214834	10/67 (15%)
		alpha/beta hydrolases	2120..>2265	CDD:473884
fasn2	XP_073801445.1	None