DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Parp and parp4

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_017213366.1	Gene:	parp4 / 558045	ZFINID:	ZDB-GENE-070912-387	Length:	1863	Species:	Danio rerio

Alignment Length:	780	Identity:	152/780 - (19%)
Similarity:	283/780 - (36%)	Gaps:	205/780 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 EKLFDQTADLLTFGAIESCSECNSCQFIVNKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELK 331
            |.::|:.|          |....:|.:.::.|..:.|..|.....|
Zfish     6 EAVYDEAA----------CPLLRACLYCISGSISLLNFTHQIIRVC------------------- 41

  Fly   332 ALYNFLNTVKEIPSTRIFNNFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLK 396
            .|| .|..:.:|.:....:||..|    :.|::...:|..|:.         .:.|:.|     |
Zfish    42 YLY-ILLYIPKILTCHSSSNFVDN----TDSIMTVFENCTVVF---------DVKNVPF-----K 87

  Fly   397 NQHKELRKRIENLGGKFEVKISENTIAIISTELEIQKKSTRMKFAEELGIHIVPIEF-------- 453
            .:.|.....:|| ||.....|::....::::.:. ...|.|.:..::|.|.:|..::
Zfish    88 EKQKLKSALLEN-GGNISYTINKECSFVVTSSVN-DLSSNRQRSIQKLQIPVVGTQYVWSCVDEG 150

  Fly   454 --LDFVEADTEGAIKYINSTCICSWGTDPKSRIPKETTKSLNSN-------------SIYTKSMP 503
              |...|.:....:.|..:..:.|.|.       ..:||.|..|             .|..|..|
Zfish   151 HLLPLTEHNLTPQLSYPTNESLPSPGV-------IVSTKILEKNKFKGQPDLPNAEVEILEKGGP 208

  Fly   504 VSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSV----------VLGLTDIQRNKNSYYKVQLL 558
            .:..|:|..|    .|..|.:....:..:  ||||          ||.|..:.......|:|...
Zfish   209 RASKFRVYKG----ADHDLPEFPSFFQVA--KYSVFEKVKPKTLSVLELQSVNGRAGQQYRVLCS 267

  Fly   559 KADKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMY 623
            ...:.|            |.:...||...:|||.|...:..:..|.      :...|.|.  ...
Zfish   268 VLREAE------------TAVLQDKLVFCETSEDAVEAYLMLMKDM------ETQGFTKT--HTL 312

  Fly   624 PIEIQ----YDDDQKLVKHESHFFTSKLEISVQNLIKLIFD--IDSMNKTLMEFHIDMDKMPLGK 682
            |.|::    |...|.|::...:..|...|:.|  .::||:.  :.|:|..|        .:|:.:
Zfish   313 PAEVEHLASYSLQQLLLEERLNCSTLSKEVGV--FVELIWTEALGSLNNIL--------TVPVSR 367

  Fly   683 LSAHQIQSAYRVVKEIYNVLECGSNTAK-LIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQM 746
            :|.:.:.....::.:.....  ..:.|| |::..|   ||:|... :..|:..:...|..||.|:
Zfish   368 ISLNDVSRVEGLLLQAQKTQ--NEDEAKALLEEVN---TLLPLRI-IDPPSKHKLVSQKLDLCQL 426

  Fly   747 LDSLAEIEVAYSIIKSEDVSDACNPLD-NHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKS 810
            :..:..:        ||....:.:|.. ..|..::..:..:...:.||..:|:.:::.
Zfish   427 IRDIVNV--------SEATLGSPSPSSLGKYRALRCSIDFVPPENPEFHAVSKLLQDR------- 476

  Fly   811 YDLKIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGY---- 871
             .::|..:.::||..|.:.|:  ::|.|.|.|.|.:..::.|||||.||.:     |..|.
Zfish   477 -PVQIQQIVRISRGVELQMFR--EELGNIKPLLHSTSPSSLVGILSRGLLL-----PRVGVELHG 533

  Fly   872 -------MFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALG---DMMECTSAKYINKLSNN 926
                   ..|.||||:|.:..|..|...|..:.:.|:|:.|||||   |:::          .:.
Zfish   534 IERTDIGNLGGGIYFSDSLKTSVKYSKPSVTDGSRLLLVCEVALGRCKDLLK----------KDT 588

  Fly   927 KHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQVNIQYL--FRME 989
            ..:|               ..||....:|...:...| |....:|::|::..|:.::|:  |.:|
Zfish   589 SLTC---------------APDGFHSVHGVRRSHNRL-SEFEDDEFVVFNTEQIRLKYVVQFTVE 637

Fly 990 989
Zfish 638 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	152/780 (19%)
		zf-PARP	10..83	CDD:279039
		zf-PARP	114..193	CDD:279039
		PADR1	270..322	CDD:285325	8/51 (16%)
		BRCT	382..454	CDD:214602	14/81 (17%)
		WGR_PARP1_like	526..629	CDD:153428	22/116 (19%)
		parp_like	645..988	CDD:238717	75/362 (21%)
parp4	XP_017213366.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810