DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Parp and parp-1

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_491072.1	Gene:	parp-1 / 266823	WormBaseID:	WBGene00004049	Length:	945	Species:	Caenorhabditis elegans

Alignment Length:	1075	Identity:	315/1075 - (29%)
Similarity:	510/1075 - (47%)	Gaps:	226/1075 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFF----KNQRPSSVG 65
            |||..|||::||:.||.||..|:.|.||:::...|.|.|..:.:|||..||:    :.:...::.
Worm     8 LPYAIEYAKSGRSNCKTCKKNIALDQLRMSMNRPSTFFDGNMDSWFHYNCFWIKMIRGRDDINIS 72

  Fly    66 DIQNIGNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKI 130
            .|:.:..||:.||::|...:::.:......|....|.. .:.|.....|.:.|:|..|..|.|..
Worm    73 SIRGVDWLRWEDQEKLRQEIQHFKTASPPTLTPLCSTT-TVILSTIKTEKSLSNRGKCGKCGQNF 136

  Fly   131 NKDLVRLRKTVYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASG--EDMPGFQSLAD-DDQAKV 192
            .:.           |:.....|:.  :|.:||.|...::    ||  ||:||:   || ::..|:
Worm   137 ERG-----------EIKAHNKGKA--NHFKCFLQEFDKI----SGTVEDIPGW---ADYEENFKI 181

  Fly   193 K------------------------NAIPP------IKSEELPDT--KR-AKMELSDTNEEGE-- 222
            |                        :..||      :.:|..|::  || |..|:.:.:.||.
Worm   182 KAVGEYVEALAAKRRSTEPATPASASPTPPEAETPVLSAEGSPESSNKRPASSEIIEIDGEGNPD 246

  Fly   223 -------------------KKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTG--DT 266
                               :|:|:|.|:|..:.:| .|..:|...|...:|:.|.|....|  .|
Worm   247 ENDFAKKRRMKKEARLMEVQKKRMKKQSDLLWEYR-QIFERMPYTDKISILRENEQDIPEGHDPT 310

  Fly   267 EKLFDQTADLLTFGAIESCSECNSCQFIVNKS--GYICNGNHSEWTKCNKLLKEPTRSACIVPKE 329
            .::.::..|...||....|..|::.:.:.|.|  .|:|.|..:|::||....|.|.|:    |.|
Worm   311 AQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATEYSKCTYESKNPIRT----PFE 371

  Fly   330 LKALYNFLNTVKEIPSTRIFNNFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIG 394
            :                             |..|.:.:|..|::.
Worm   372 V-----------------------------SHRLTEKHKLQDIVF-------------------- 387

  Fly   395 LKNQHKELRKRIENLGGKFEVKISENTIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEA 459
              ||..|                                   |:...||.|..:|.|:     :.
Worm   388 --NQMSE-----------------------------------RLYIGEEDGESVVKID-----KR 410

  Fly   460 DTEGAIKYINSTCICSWGTDPKSRI-PKETTKSLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLE 523
            .::|             ||..:..| ..|...|.|:..|....:..:.|..:|.|..||....|.
Worm   411 KSKG-------------GTRGEQFIYAAEAFDSTNNVPIKVGDLTSTNTHIIKKGTVVDAKFALA 462

  Fly   524 DIAHVYVD--SNNKYSVVLGLTDIQRNKNSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEE 586
            |..||:.:  ..:.|...|..||:.:|||||||:||||.|::|.|::||||||:||.:|.:|.|.
Worm   463 DRCHVFKNEIDGSLYQATLSFTDLTQNKNSYYKIQLLKDDQRENYYVFRSWGRVGTEVGGNKHES 527

  Fly   587 FDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHE-SHFFTSKLEIS 650
            :..|..|...|::::.:||.|::..|.:|.|..|....:|..|.:..::...| :....:.|..|
Worm   528 YSNSNEAILKFQDVFHEKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKS 592

  Fly   651 VQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYNVL-ECGSNTAKLIDA 714
            |:.::..|||:::|...|..|.:|::|||||:||.:||..|:.|:.:|.::| :...:.::::|.
Worm   593 VKEVVMSIFDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDF 657

  Fly   715 TNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDV----SDACNPLDNH 775
            :|:|||:||||||:::|..|::..:|::...||::|.:|:.||..|...||    |...:|:|.:
Worm   658 SNKFYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVDIN 722

  Fly   776 YAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKI--VDVFKVSRQGEARRFKPFKKLHN 838
            |.::|..:..|.:..::::::.||:||||.:||   |||:  :|:.|::|..|:.:||  :.:.|
Worm   723 YQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATH---DLKVELIDILKLNRDNESSKFK--RHIGN 782

  Fly   839 RKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLL 903
            |:||||||...||.|||..||||||||||.:|||||||:|||||.|||..| |.:.......:||
Worm   783 RRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFY-CRANAKEEAYLLL 846

  Fly   904 SEVALGDMMECTSAKYINK--LSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETI-------- 958
            .:||||::.:..::|.:::  |.....|..|.||..|....||...||..||.|.|.
Worm   847 CDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLGLTYMQLQGKQD 911

  Fly   959 TDEHLKSSLLYNEYIVYDVAQVNIQYLFRMEFKYS 993
            .|.|    |||||:|||||.|:.::||.|::..::
Worm   912 VDYH----LLYNEFIVYDVDQIQLKYLVRVKMHHA 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	314/1071 (29%)
		zf-PARP	10..83	CDD:279039	27/76 (36%)
		zf-PARP	114..193	CDD:279039	21/81 (26%)
		PADR1	270..322	CDD:285325	15/53 (28%)
		BRCT	382..454	CDD:214602	9/71 (13%)
		WGR_PARP1_like	526..629	CDD:153428	42/104 (40%)
		parp_like	645..988	CDD:238717	145/359 (40%)
parp-1	NP_491072.1	PLN03123	5..943	CDD:215590	315/1075 (29%)
		zf-PARP	13..90	CDD:279039	27/76 (36%)
		RRS1	<236..272	CDD:295203	4/35 (11%)
		PADR1	314..368	CDD:285325	15/53 (28%)
		WGR_PARP1_like	465..570	CDD:153428	42/104 (40%)
		parp_like	586..938	CDD:238717	146/361 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157481
Domainoid	1	1.000	166	1.000	Domainoid score	I2360
eggNOG	1	0.900	-	-		E1_KOG1037
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1222
Inparanoid	1	1.050	460	1.000	Inparanoid score	I877
Isobase	1	0.950	-	0	Normalized mean entropy	S4640
OMA	1	1.010	-	-		QHG56136
OrthoDB	1	1.010	-	-		D121455at33208
OrthoFinder	1	1.000	-	-		FOG0006410
OrthoInspector	1	1.000	-	-		oto19633
orthoMCL	1	0.900	-	-		OOG6_101236
Panther	1	1.100	-	-	LDO	PTHR10459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4711
SonicParanoid	1	1.000	-	-		X4674
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790