Protein Alignment Parp1 and parp-1

DIOPT Version :10

• Sequence 1: NP_001104452.1
• Gene: Parp1 / 3355109
• FlyBaseID: FBgn0010247
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_491072.1
• Gene: parp-1 / 266823
• WormBaseID: WBGene00004049
• Length: 945
• Species: Caenorhabditis elegans
• Alignment Length: 1075
• Identity: 315/1075 - (29%)
• Similarity: 510/1075 - (47%)
• Gaps: 226/1075 - (21%)

  Fly     5 LPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFF----KNQRPSSVG 65
            |||..|||::||:.||.||..|:.|.||:::...|.|.|..:.:|||..||:    :.:...::.
 Worm     8 LPYAIEYAKSGRSNCKTCKKNIALDQLRMSMNRPSTFFDGNMDSWFHYNCFWIKMIRGRDDINIS 72

  Fly    66 DIQNIGNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKI 130
            .|:.:..||:.||::|...:::.:......|....|.. .:.|.....|.:.|:|..|..|.|..
 Worm    73 SIRGVDWLRWEDQEKLRQEIQHFKTASPPTLTPLCSTT-TVILSTIKTEKSLSNRGKCGKCGQNF 136

  Fly   131 NKDLVRLRKTVYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASG--EDMPGFQSLAD-DDQAKV 192
            .:.           |:.....|:.  :|.:||.|...::    ||  ||:||:   || ::..|:
 Worm   137 ERG-----------EIKAHNKGKA--NHFKCFLQEFDKI----SGTVEDIPGW---ADYEENFKI 181

  Fly   193 K------------------------NAIPP------IKSEELPDT--KR-AKMELSDTNEEGE-- 222
            |                        :..||      :.:|..|::  || |..|:.:.:.||.
 Worm   182 KAVGEYVEALAAKRRSTEPATPASASPTPPEAETPVLSAEGSPESSNKRPASSEIIEIDGEGNPD 246

  Fly   223 -------------------KKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTG--DT 266
                               :|:|:|.|:|..:.:| .|..:|...|...:|:.|.|....|  .|
 Worm   247 ENDFAKKRRMKKEARLMEVQKKRMKKQSDLLWEYR-QIFERMPYTDKISILRENEQDIPEGHDPT 310

  Fly   267 EKLFDQTADLLTFGAIESCSECNSCQFIVNKS--GYICNGNHSEWTKCNKLLKEPTRSACIVPKE 329
            .::.::..|...||....|..|::.:.:.|.|  .|:|.|..:|::||....|.|.|:    |.|
 Worm   311 AQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATEYSKCTYESKNPIRT----PFE 371

  Fly   330 LKALYNFLNTVKEIPSTRIFNNFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIG 394
            :                             |..|.:.:|..|::.
 Worm   372 V-----------------------------SHRLTEKHKLQDIVF-------------------- 387

  Fly   395 LKNQHKELRKRIENLGGKFEVKISENTIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEA 459
              ||..|                                   |:...||.|..:|.|:     :.
 Worm   388 --NQMSE-----------------------------------RLYIGEEDGESVVKID-----KR 410

  Fly   460 DTEGAIKYINSTCICSWGTDPKSRI-PKETTKSLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLE 523
            .::|             ||..:..| ..|...|.|:..|....:..:.|..:|.|..||....|.
 Worm   411 KSKG-------------GTRGEQFIYAAEAFDSTNNVPIKVGDLTSTNTHIIKKGTVVDAKFALA 462

  Fly   524 DIAHVYVD--SNNKYSVVLGLTDIQRNKNSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEE 586
            |..||:.:  ..:.|...|..||:.:|||||||:||||.|::|.|::||||||:||.:|.:|.|.
 Worm   463 DRCHVFKNEIDGSLYQATLSFTDLTQNKNSYYKIQLLKDDQRENYYVFRSWGRVGTEVGGNKHES 527

  Fly   587 FDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHE-SHFFTSKLEIS 650
            :..|..|...|::::.:||.|::..|.:|.|..|....:|..|.:..::...| :....:.|..|
 Worm   528 YSNSNEAILKFQDVFHEKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKS 592

  Fly   651 VQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYNVL-ECGSNTAKLIDA 714
            |:.::..|||:::|...|..|.:|::|||||:||.:||..|:.|:.:|.::| :...:.::::|.
 Worm   593 VKEVVMSIFDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDF 657

  Fly   715 TNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDV----SDACNPLDNH 775
            :|:|||:||||||:::|..|::..:|::...||::|.:|:.||..|...||    |...:|:|.:
 Worm   658 SNKFYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVDIN 722

  Fly   776 YAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKI--VDVFKVSRQGEARRFKPFKKLHN 838
            |.::|..:..|.:..::::::.||:||||.:||   |||:  :|:.|::|..|:.:||  :.:.|
 Worm   723 YQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATH---DLKVELIDILKLNRDNESSKFK--RHIGN 782

  Fly   839 RKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLL 903
            |:||||||...||.|||..||||||||||.:|||||||:|||||.|||..| |.:.......:||
 Worm   783 RRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFY-CRANAKEEAYLLL 846

  Fly   904 SEVALGDMMECTSAKYINK--LSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETI-------- 958
            .:||||::.:..::|.:::  |.....|..|.||..|....||...||..||.|.|.
 Worm   847 CDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLGLTYMQLQGKQD 911

  Fly   959 TDEHLKSSLLYNEYIVYDVAQVNIQYLFRMEFKYS 993
            .|.|    |||||:|||||.|:.::||.|::..::
 Worm   912 VDYH----LLYNEFIVYDVDQIQLKYLVRVKMHHA 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Parp1	NP_001104452.1	PLN03123	6..992	CDD:215590	314/1071 (29%)
parp-1	NP_491072.1	PLN03123	5..943	CDD:215590	315/1075 (29%)