Protein Alignment Parp1 and Parp1

DIOPT Version :10

• Sequence 1: NP_001104452.1
• Gene: Parp1 / 3355109
• FlyBaseID: FBgn0010247
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_037195.1
• Gene: Parp1 / 25591
• RGDID: 2053
• Length: 1014
• Species: Rattus norvegicus
• Alignment Length: 1055
• Identity: 424/1055 - (40%)
• Similarity: 620/1055 - (58%)
• Gaps: 123/1055 - (11%)

  Fly     7 YLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFK----NQRPSSVGDI 67
            |..|||::|||:||.|..:|.||:||:|:||||...|.|||:|:|.:||:|    .::|.:  ::
  Rat     9 YRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDT--EV 71

  Fly    68 QNIGNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLA--------------LKDFGIEYAKS 118
            .....||:.||:::                ||.::|..:|              |.||..|||||
  Rat    72 DGFSELRWDDQQKV----------------KKTAEAGGVAGKGQHGGGGKAEKTLGDFAAEYAKS 120

  Fly   119 SRSTCRGCEQKINKDLVRLRKTVYDTE---VGMKYGGQPLWHHLECFAQLRSELGWFA--SGEDM 178
            :||||:||.:||.|..:||.|.:.|.|   :||    ...|:|..||.:.|.|||:..  |...:
  Rat   121 NRSTCKGCMEKIEKGQMRLSKKMLDPEKPQLGM----IDRWYHPTCFVKNRDELGFRPEYSASQL 181

  Fly   179 PGFQSLADDDQAKVKNAIPPIKSEELPDTKRAKMELSDTNEEGEKKQR-------------LKDQ 230
            .||..|:.:|:..:|..:|.:|||    .||...|:...:|..:||.:             ||.|
  Rat   182 KGFSLLSAEDKEALKKQLPAVKSE----GKRKCDEVDGIDEVAKKKSKKGKDKESSKLEKALKAQ 242

  Fly   231 NDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFGAIESCSECNSCQFIV 295
            |:..:..:|::|......|:..||.||.||..:|:: .:.|:.||.:.|||:..|.|| |.|.:.
  Rat   243 NELVWNIKDELKKACSTNDLKELLIFNQQQVPSGES-AILDRVADGMAFGALLPCKEC-SGQLVF 305

  Fly   296 NKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFNNFPPNKSTFS 360
            ....|.|.|:.:.||||....:.|:|...:.|||.:.: ::|..:|.....|:   |||..|.
  Rat   306 KSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREI-SYLKKLKIKKQDRL---FPPESSA-- 364

  Fly   361 RSLLKTNKNNDVLVRPTIPRIS---------------PPLYNLKFSIIGLKNQHK-ELRKRIENL 409
                         ..|..|.:|               .||.|:|...:|..:|:| |.:..||.|
  Rat   365 -------------PAPPAPPVSITSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAMIEKL 416

  Fly   410 GGKFEVKISENTIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCIC 474
            |||.....::.::. |||:.|::|.|.:|:..:...:.:|..:||..|.|..:...:.:::..:.
  Rat   417 GGKLTGSANKASLC-ISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASAKSLQELLSAHSLS 480

  Fly   475 SWGTD----------PKSRIPKETTKSLNSNSIYTKSMPVSRTFK-----VKDGLAVDPDSGLED 524
            |||.:          ||.:....:.||..:    .|...|:::.|     :|.|.|||||||||.
  Rat   481 SWGAEVKVEPGEVVVPKGKSAAPSKKSKGA----VKEEGVNKSEKRMKLTLKGGAAVDPDSGLEH 541

  Fly   525 IAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEEFDT 589
            .|||.......:|..|||.||.:..|||||:|||::||:.:|||||||||:||.||::|||:..:
  Rat   542 SAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLESDKESRYWIFRSWGRVGTVIGSNKLEQMPS 606

  Fly   590 SESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKH--ESHFFTSKLEISVQ 652
            .|.|..:|.::|.:||||.:..: ||.|...:.||:||.|..|::.||.  ......|||...||
  Rat   607 KEDAVEHFMKLYEEKTGNAWHSK-NFTKYPKKFYPLEIDYGQDEEAVKKLAVKPGTKSKLPKPVQ 670

  Fly   653 NLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNR 717
            .|:.:|||::||.|.|:|:.||:.||||||||..|||:||.::.|:...:..||:.::::|.:||
  Rat   671 ELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNR 735

  Fly   718 FYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACNPLDNHYAQIKTQ 782
            |||||||:||::.|.|:.....::...:|||:|.:||||||:::......:.:|:|.:|.::||.
  Rat   736 FYTLIPHDFGMKKPPLLNNTDSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTD 800

  Fly   783 LVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSR 847
            :..:|::|||..::.:|||||||:||.:|||:::|:||:.|:||::|:|||::||||:|||||||
  Rat   801 IKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSR 865

  Fly   848 LTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGDMM 912
            .|||.||||.||||||||||.||||||||||||||||||||||.|||.:..||:||.|||||:|.
  Rat   866 TTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMY 930

  Fly   913 ECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDV 977
            |...|.:|:||...|||..|.|:|.|||:.| |..||||:|.|..|......:.||||||||||:
  Rat   931 ELKHASHISKLPKGKHSVKGLGKTAPDPSAS-ITLDGVEVPLGTGIPSGVNDTCLLYNEYIVYDI 994

  Fly   978 AQVNIQYLFRMEFKY 992
            ||||::||.:::|.:
  Rat   995 AQVNLKYLLKLKFNF 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Parp1	NP_001104452.1	PLN03123	6..992	CDD:215590	424/1053 (40%)
Parp1	NP_037195.1	PLN03123	9..1010	CDD:215590	424/1055 (40%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P09874	207..209		0/1 (0%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P09874	221..226		1/4 (25%)
		Zinc ribbon. /evidence=ECO:0000255|PROSITE-ProRule:PRU01351	291..333		14/41 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..387		4/44 (9%)
		Automodification domain. /evidence=ECO:0000250|UniProtKB:P09874	374..524		47/180 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..519		6/27 (22%)