DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Parp and tank-1

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_503401.3	Gene:	tank-1 / 178623	WormBaseID:	WBGene00004053	Length:	2276	Species:	Caenorhabditis elegans

Alignment Length:	649	Identity:	154/649 - (23%)
Similarity:	270/649 - (41%)	Gaps:	155/649 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 KISENTIAIISTELEIQKKSTRMKFAEELG--------------IHIVPIEFLDFVEADTEGAIK 466
            |.|.|.|.:.:.::..:.||..:|..:...              :||.|:..:|      |.|.|
Worm  1700 KRSPNPIELAAMKMNRRMKSEMLKIVKNAAFPRPIKETKLTLQQVHIEPLSDVD------EDAAK 1758

  Fly   467 YINSTCICSWGTDPKSRIPKETTKSLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVD 531
            :     :..|..:...:...|..|. :.:|.|:.:..||                       :.|
Worm  1759 F-----LAKWVEEKDKKKTSEAPKP-HKSSTYSTNGLVS-----------------------FCD 1794

  Fly   532 SNNKY-SVVLGLTDIQRNK---NSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEEFDTSES 592
            ...:| .|::..||:...:   :::|::|::|....|.:.:|.:|||||:.:|..:...|::.|.
Worm  1795 ETQQYFDVLMNKTDLMYGRCGFHNFYRMQIIKRRDAELFILFTNWGRIGSGMGEFQTTPFNSLEL 1859

  Fly   593 AKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHESHFFTSKLEISV------ 651
            |.:.||.|:..|:|||:....||     |..|      ...:||:.:| ..||..||.:
Worm  1860 AAKEFKSIFKSKSGNEWAPLANF-----RDMP------KKYRLVETDS-TPTSLAEIELTWKKNT 1912

  Fly   652 --QNLIKLIFDIDSMNKTLMEF--HIDM---DKMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTA 709
              ..:.::|.|| |..|||..:  .:.|   ...|.|:.:...|:.|    |.:.:.||..:|..
Worm  1913 EKDPIRRMIADI-SDAKTLKTYASQVQMYGGSSQPFGRFTKENIEKA----KLVLDKLEKNANRI 1972

  Fly   710 K-------------LIDA-------TNRFYTLIPH-NFGVQLPTLIETHQQIEDLRQMLDSLAEI 753
            |             |:||       :..:|:|||. .:.....|.::..::|...|..|:...||
Worm  1973 KQMVEAQTGVVESNLLDAYITTSELSGDYYSLIPSGEYEFSNLTRLDNVEEIARHRARLNRCQEI 2037

  Fly   754 EVAYSIIKSEDVSDACNPLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDV 818
            |.|..::.:.:.....:.:|...:.|:.:......:|:....|.|::.|:...     ..|:..:
Worm  2038 ETATRLLCAAEFRQDLDRVDYIRSAIQCEYRLETPDSDISQRLLQWIHNSGGK-----QAKVKMI 2097

  Fly   819 FKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMV 883
            .::|......:|:||....|:|.||||::.||.:.||.:|..|.||.|...|.:||.|||.||..
Worm  2098 LEISPMLSTEKFEPFVNDDNQKFLWHGTKATNLMSILKNGFLIDPPSACKNGNLFGSGIYLADSF 2162

  Fly   884 SKSANYCCTSQQNSTGL--MLLSEVALGDM--MECTSAKYINKLSNNKHSCFGRGRTMPDPTKSY 944
            .||.:||   |.::.|:  ||:.:.|||.:  ::.....|:|:.|::....        :.|..|
Worm  2163 EKSTHYC---QPSAGGINYMLVCQTALGKVRTLDTIPYHYMNQSSSSAEKY--------EDTLHY 2216

  Fly   945 I---------RSDGVEIP--------------YGETITDEHLKSSLLYNEYIVYDVAQVNIQYL 985
            |         .:|||.:|              ||....|        ::||||.:..:|..:|:
Worm  2217 IGDRFPAGSLTNDGVGMPLLPLRKRDPIQGSNYGFGTLD--------FSEYIVRNPNRVLPKYI 2272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	154/649 (24%)
		zf-PARP	10..83	CDD:279039
		zf-PARP	114..193	CDD:279039
		PADR1	270..322	CDD:285325
		BRCT	382..454	CDD:214602	10/51 (20%)
		WGR_PARP1_like	526..629	CDD:153428	30/106 (28%)
		parp_like	645..988	CDD:238717	99/402 (25%)
tank-1	NP_503401.3	ANK repeat	348..376	CDD:293786
		Ank_2	350..438	CDD:289560
		ANK	373..519	CDD:238125
		ANK repeat	378..409	CDD:293786
		ANK repeat	411..459	CDD:293786
		Ank_2	416..529	CDD:289560
		ANK	456..584	CDD:238125
		ANK repeat	461..496	CDD:293786
		ANK repeat	501..529	CDD:293786
		Ank_2	503..591	CDD:289560
		ANK	528..656	CDD:238125
		ANKYR	529..769	CDD:223738
		ANK repeat	531..562	CDD:293786
		ANK repeat	598..633	CDD:293786
		ANK	602..750	CDD:238125
		ANK repeat	675..727	CDD:293786
		ANK repeat	729..754	CDD:293786
		ANK repeat	1050..1082	CDD:293786
		ANK repeat	1084..1120	CDD:293786
		ANK	1117..1234	CDD:238125
		ANK repeat	1124..1169	CDD:293786
		Ank_2	1146..1234	CDD:289560
		ANK repeat	1171..1202	CDD:293786
		ANK repeat	1204..1232	CDD:293786
		ANK	<1476..1526	CDD:238125
		ANK repeat	1476..1503	CDD:293786
		Ank_2	1477..>1529	CDD:289560
		ANK repeat	1505..1529	CDD:293786
		WGR_PARP	1793..1896	CDD:153426	32/113 (28%)
		parp_like	1910..2276	CDD:238717	96/392 (24%)
		PARP	2078..2276	CDD:279038	61/219 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4640
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860