DRSC/TRiP Functional Genomics Resources

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Protein Alignment Parp1 and PARP4

DIOPT Version :10

Sequence 1:NP_001104452.1 Gene:Parp1 / 3355109 FlyBaseID:FBgn0010247 Length:994 Species:Drosophila melanogaster
Sequence 2:NP_006428.2 Gene:PARP4 / 143 HGNCID:271 Length:1724 Species:Homo sapiens


Alignment Length:635 Identity:129/635 - (20%)
Similarity:245/635 - (38%) Gaps:134/635 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   396 KNQHKELRKRIENLGGKFEVKISENTIAIISTELEIQKKSTRMKFAEELGIHIVPIEF------- 453
            :.|.|:|:..|:..||||...::.....||....::..: .::...::..:||...:|       
Human    20 QQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQ-YQLNSIQKNHVHIANPDFIWKSIRE 83

  Fly   454 ---LDFVEAD-------TEGAIKYINSTCICSWGTDPKSRIPKETTKSLNSNSIYTKSMP-VSRT 507
               ||....|       |....:..:|:.:.:.|..|.|...:|.|..|....:....:| :.:.
Human    84 KRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCPDSATEEEDTVELTEFGMQNVEIPHLPQD 148

  Fly   508 FKV-------KDGLAVDPDSGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKADKKEK 565
            |:|       |.|:    :.|.|.:                :.::|.::           |.::.
Human   149 FEVAKYNTLEKVGM----EGGQEAV----------------VVELQCSR-----------DSRDC 182

  Fly   566 YWIFRSWGRIGTNIGNSKLEEF---DTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEI 627
            .::..|  ....:.|.....:|   .|||.|...|:....:.....:..|::|.....::...::
Human   183 PFLISS--HFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQLASEQL 245

  Fly   628 QYDDDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHID-MDKMPLGKLSAHQIQSA 691
            |      .:..|....:|.|...|.:|:::|: .:::.      |:: |...|:.::|.:.:..|
Human   246 Q------ALLLEEVMNSSTLSQEVSDLVEMIW-AEALG------HLEHMLLKPVNRISLNDVSKA 297

  Fly   692 YRVVKEIYNVLECGSNTAKLIDATNRFYTLIPH--------NFGVQLPTLIETHQQIEDLRQMLD 748
            ..::..:...|:.|....:|......||.||||        |.|: |....:..|.|.|:..:.:
Human   298 EGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGL-LAKKADLCQLIRDMVNVCE 361

  Fly   749 SLAEIEVAYSIIKSEDVSDACNPLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDL 813
            :              ::|....|....|..::.::..:::|:|||..:.:.|...|   |....:
Human   362 T--------------NLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNH---HSKSPV 409

  Fly   814 KIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYM------ 872
            .::.:|:|.|..|...|  ..||.|.:.|.|||.:.|.||||..|| :.|......|..      
Human   410 DVLQIFRVGRVNETTEF--LSKLGNVRPLLHGSPVQNIVGILCRGL-LLPKVVEDRGVQRTDVGN 471

  Fly   873 FGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGDMMECTSAKYINKLSNNKHSCFGRGRTM 937
            .|.||||:|.:|.|..|....:.:.|.|:|:.:||||..|:.....:                ::
Human   472 LGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDF----------------SL 520

  Fly   938 PDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQVNIQYLFR 987
            .:....|....||......|...|.       :|::||...||.::|:.:
Human   521 TEAPPGYDSVHGVSQTASVTTDFED-------DEFVVYKTNQVKMKYIIK 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Parp1NP_001104452.1 PLN03123 6..992 CDD:215590 129/635 (20%)
PARP4NP_006428.2 BRCT_PARP4_like 5..88 CDD:349358 13/68 (19%)
Nuclear localization signal. /evidence=ECO:0000255 19..25 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..123 4/25 (16%)
parp_like 251..565 CDD:238717 85/364 (23%)
catalytic domain 409..563 49/179 (27%)
VIT 623..733 CDD:462492
transmembrane domain 737..753
VWA 877..1033 CDD:214621
Nuclear localization signal. /evidence=ECO:0000255 1237..1249
KLF1_2_4_N <1317..1485 CDD:425360
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1452
Interaction with the major vault protein. /evidence=ECO:0000269|PubMed:10477748 1562..1724
Blue background indicates that the domain is not in the aligned region.

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