DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Parp and PARP4

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_011533233.1	Gene:	PARP4 / 143	HGNCID:	271	Length:	1771	Species:	Homo sapiens

Alignment Length:	414	Identity:	93/414 - (22%)
Similarity:	169/414 - (40%)	Gaps:	72/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 TSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHESHFFTSKLEISVQN 653
            |||.|...|:....:.....:..|::|.....::...::|      .:..|....:|.|...|.:
Human   254 TSEDASEYFENYIEELKKQGFLLREHFTPEATQLASEQLQ------ALLLEEVMNSSTLSQEVSD 312

  Fly   654 LIKLIFDIDSMNKTLMEFHID-MDKMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNR 717
            |:::|: .:::.      |:: |...|:.::|.:.:..|..::..:...|:.|....:|......
Human   313 LVEMIW-AEALG------HLEHMLLKPVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTE 370

  Fly   718 FYTLIPH--------NFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACNPLDN 774
            ||.||||        |.|: |....:..|.|.|:..:.::              ::|....|...
Human   371 FYRLIPHKGTMPKEVNLGL-LAKKADLCQLIRDMVNVCET--------------NLSKPNPPSLA 420

  Fly   775 HYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNR 839
            .|..::.::..:::|:|||..:.:.|...|   |....:.::.:|:|.|..|...|  ..||.|.
Human   421 KYRALRCKIEHVEQNTEEFLRVRKEVLQNH---HSKSPVDVLQIFRVGRVNETTEF--LSKLGNV 480

  Fly   840 KLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYM------FGKGIYFADMVSKSANYCCTSQQNST 898
            :.|.|||.:.|.||||..|| :.|......|..      .|.||||:|.:|.|..|....:.:.|
Human   481 RPLLHGSPVQNIVGILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGT 544

  Fly   899 GLMLLSEVALGDMMECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHL 963
            .|:|:.:||||..|:.....:                ::.:....|....||......|...|.
Human   545 RLLLICDVALGKCMDLHEKDF----------------SLTEAPPGYDSVHGVSQTASVTTDFED- 592

  Fly   964 KSSLLYNEYIVYDVAQVNIQYLFR 987
                  :|::||...||.::|:.:
Human   593 ------DEFVVYKTNQVKMKYIIK 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	93/414 (22%)
		zf-PARP	10..83	CDD:279039
		zf-PARP	114..193	CDD:279039
		PADR1	270..322	CDD:285325
		BRCT	382..454	CDD:214602
		WGR_PARP1_like	526..629	CDD:153428	7/39 (18%)
		parp_like	645..988	CDD:238717	84/358 (23%)
PARP4	XP_011533233.1	BRCT	<91..135	CDD:381769
		parp_like	298..612	CDD:238717	85/364 (23%)
		VIT	670..780	CDD:378008
		marine_srt_targ	683..1231	CDD:274782
		MISS	1355..>1509	CDD:318115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810