DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Parp and PARP1

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001609.2	Gene:	PARP1 / 142	HGNCID:	270	Length:	1014	Species:	Homo sapiens

Alignment Length:	1042	Identity:	427/1042 - (40%)
Similarity:	619/1042 - (59%)	Gaps:	97/1042 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVG------ 65
            |..|||::|||:||.|..:|.||:||:|:||||...|.|||:|:|.:||:|      ||
Human     9 YRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWK------VGHSIRHP 67

  Fly    66 --DIQNIGNLRFADQKELTDLVENIQEVISAQ--LGKKRSKAFNLALKDFGIEYAKSSRSTCRGC 126
              ::.....||:.||:::....|........|  :|.|..|    .|.||..|||||:||||:||
Human    68 DVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEK----TLGDFAAEYAKSNRSTCKGC 128

  Fly   127 EQKINKDLVRLRKTVYDTE---VGMKYGGQPLWHHLECFAQLRSELGWFA--SGEDMPGFQSLAD 186
            .:||.|..|||.|.:.|.|   :||    ...|:|..||.:.|.|||:..  |...:.||..||.
Human   129 MEKIEKGQVRLSKKMVDPEKPQLGM----IDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLAT 189

  Fly   187 DDQAKVKNAIPPIKSEELPDTKRAKMELSDTNEEGEKKQR------------LKDQNDAYFRFRD 239
            :|:..:|..:|.:|||    .||...|:...:|..:||.:            ||.|||..:..:|
Human   190 EDKEALKKQLPGVKSE----GKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKD 250

  Fly   240 DIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFGAIESCSECNSCQFIVNKSGYICNG 304
            ::|......|:..||.||.||..:|:: .:.|:.||.:.|||:..|.|| |.|.:.....|.|.|
Human   251 ELKKVCSTNDLKELLIFNKQQVPSGES-AILDRVADGMVFGALLPCEEC-SGQLVFKSDAYYCTG 313

  Fly   305 NHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIF--------NNFPPNKSTFSR 361
            :.:.||||....:.|.|...:.|||.:.: ::|..:|.....|||        ...||..:..:.
Human   314 DVTAWTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKVKKQDRIFPPETSASVAATPPPSTASAP 377

  Fly   362 SLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLKNQHK-ELRKRIENLGGKFEVKISENTIAII 425
            :.:.::.:.|           .||.|:|...:|..:::| |::..||.||||.....::.::. |
Human   378 AAVNSSASAD-----------KPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLC-I 430

  Fly   426 STELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSR------- 483
            ||:.|::|.:.:|:..:|..|.:|..:||..|.|.|:...:...:..:..||.:.|:.
Human   431 STKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAP 495

  Fly   484 -------IPKETTKSLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSVVLG 541
                   :.|::...:....|......:..|  :|.|.|||||||||..|||.......:|..||
Human   496 RGKSGAALSKKSKGQVKEEGINKSEKRMKLT--LKGGAAVDPDSGLEHSAHVLEKGGKVFSATLG 558

  Fly   542 LTDIQRNKNSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTG 606
            |.||.:..|||||:|||:.||:.:|||||||||:||.||::|||:..:.|.|..:|.::|.:|||
Human   559 LVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTG 623

  Fly   607 NEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHESHFFT------SKLEISVQNLIKLIFDIDSMN 665
            |.:..: ||.|...:.||:||.|..|::.||.    .|      |||...||:|||:|||::||.
Human   624 NAWHSK-NFTKYPKKFYPLEIDYGQDEEAVKK----LTVNPGTKSKLPKPVQDLIKMIFDVESMK 683

  Fly   666 KTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNRFYTLIPHNFGVQL 730
            |.::|:.||:.||||||||..|||:||.::.|:...:..||:.::::|.:|||||||||:||::.
Human   684 KAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKK 748

  Fly   731 PTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACNPLDNHYAQIKTQLVALDKNSEEFSI 795
            |.|:.....::...:|||:|.:||||||:::......:.:|:|.:|.::||.:..:|::|||..|
Human   749 PPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEI 813

  Fly   796 LSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLR 860
            :.:|||||||:||.:|||:::|:||:.|:||.:|:||||:||||:|||||||.|||.||||.|||
Human   814 IRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLR 878

  Fly   861 IAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGDMMECTSAKYINKLSN 925
            |||||||.||||||||||||||||||||||.|||.:..||:||.|||||:|.|...|.:|:||..
Human   879 IAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPK 943

  Fly   926 NKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQVNIQYLFRMEF 990
            .|||..|.|:|.|||:.: |..|||::|.|..|:.....:|||||||||||:||||::||.:::|
Human   944 GKHSVKGLGKTTPDPSAN-ISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKF 1007

  Fly   991 KY 992
            .:
Human  1008 NF 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	427/1040 (41%)
		zf-PARP	10..83	CDD:279039	34/80 (43%)
		zf-PARP	114..193	CDD:279039	36/83 (43%)
		PADR1	270..322	CDD:285325	19/51 (37%)
		BRCT	382..454	CDD:214602	22/72 (31%)
		WGR_PARP1_like	526..629	CDD:153428	50/102 (49%)
		parp_like	645..988	CDD:238717	191/342 (56%)
PARP1	NP_001609.2	PARP_reg	6..1010	CDD:332154	427/1042 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..233		10/38 (26%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:1505517	207..209		1/1 (100%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:1505517	221..226		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..385		2/23 (9%)
		Automodification domain. /evidence=ECO:0000303\|PubMed:19764761	373..524		33/162 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143126
Domainoid	1	1.000	267	1.000	Domainoid score	I1877
eggNOG	1	0.900	-	-		E1_KOG1037
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1222
Inparanoid	1	1.050	760	1.000	Inparanoid score	I550
Isobase	1	0.950	-	0	Normalized mean entropy	S4640
OMA	1	1.010	-	-		QHG56136
OrthoDB	1	1.010	-	-		D121455at33208
OrthoFinder	1	1.000	-	-		FOG0006410
OrthoInspector	1	1.000	-	-		oto89416
orthoMCL	1	0.900	-	-		OOG6_101236
Panther	1	1.100	-	-	LDO	PTHR10459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4711
SonicParanoid	1	1.000	-	-		X4674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750