Protein Alignment Parp and Parp2

DIOPT Version :9

• Sequence 1: NP_001104452.1
• Gene: Parp / 3355109
• FlyBaseID: FBgn0010247
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_033762.1
• Gene: Parp2 / 11546
• MGIID: 1341112
• Length: 559
• Species: Mus musculus
• Alignment Length: 516
• Identity: 208/516 - (40%)
• Similarity: 315/516 - (61%)
• Gaps: 24/516 - (4%)

  Fly   487 ETTKSLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLE-DIAHVYVDSNNKYSVVLGLTDIQRNKN 550
            :.||. |.:|:        :|..:|....|||:...: ..||||.:.::.|.|:|..|::|.|.|
Mouse    54 DRTKD-NRDSV--------KTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNN 109

  Fly   551 SYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNF 615
            .||.:|||:.|.:..:.::..|||:|....:|.:........||..|::.:.|||.|.:|.|:||
Mouse   110 KYYLIQLLEDDAQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENF 174

  Fly   616 VKRTGRMYPIEIQY----DDDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMD 676
            .|..|:...:::.|    .|:.|..:.|:....|:|::.||.|:|||.::.:|.:.::|...|..
Mouse   175 EKVPGKYDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTK 239

  Fly   677 KMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIE 741
            :.|||||:..||::.|:.:|:|.:.:..|.:...|::|.|.|||.|||:||:.:|.:|.|.:::.
Mouse   240 RAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTEKELS 304

  Fly   742 DLRQMLDSLAEIEVAYSIIKSEDVSDACNPLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHAS 806
            |..::|::|.:||:|..::|||. ....:|||.||..:...|..||..|.||.::|||:::|||.
Mouse   305 DKVKLLEALGDIEIALKLVKSER-QGLEHPLDQHYRNLHCALRPLDHESNEFKVISQYLQSTHAP 368

  Fly   807 THKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGY 871
            |||.|.:.::|||:|.::||...|:  :.|.||.||||||||:|:|||||||||:||||||.|||
Mouse   369 THKDYTMTLLDVFEVEKEGEKEAFR--EDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGY 431

  Fly   872 MFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGDMMECTSAK-YINKLSNNKHSCFGRGR 935
            |||||||||||.|||||||..|:..:|||:||||||||...|...|. ....|...|||..|.|:
Mouse   432 MFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAQGLLRGKHSTKGMGK 496

  Fly   936 TMPDPTKSYIRSDGVEIPYGETITDEHLKS----SLLYNEYIVYDVAQVNIQYLFRMEFKY 992
            ..|.|. .:|..:|..:|.|.. :|..:.:    :|.|||:|||...||.::||.:::|.:
Mouse   497 MAPSPA-HFITLNGSTVPLGPA-SDTGILNPEGYTLNYNEFIVYSPNQVRMRYLLKIQFNF 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	208/514 (40%)
		zf-PARP	10..83	CDD:279039
		zf-PARP	114..193	CDD:279039
		PADR1	270..322	CDD:285325
		BRCT	382..454	CDD:214602
		WGR_PARP1_like	526..629	CDD:153428	35/102 (34%)
		parp_like	645..988	CDD:238717	159/347 (46%)
Parp2	NP_033762.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		1/3 (33%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9UGN5	19..20
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9UGN5	33..39
		WGR_PARP2_like	86..188	CDD:153430	34/101 (34%)
		parp_like	207..552	CDD:238717	159/349 (46%)
		PARP	341..553	CDD:279038	109/215 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720