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Protein Alignment Parp and PARP2

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_005475.2	Gene:	PARP2 / 10038	HGNCID:	272	Length:	583	Species:	Homo sapiens

Alignment Length:	575	Identity:	218/575 - (37%)
Similarity:	331/575 - (57%)	Gaps:	52/575 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 GAIKYIN-STCICSWGTDPKSRIPKETTKSLNSNSIYTKSMPVS-------RTFKVKDGL----- 514
            |..:.:| |..:.:..|.|:...|.:.|:......  :|.|||:       ||...:||:
Human    12 GRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQE--SKKMPVAGGKANKDRTEDKQDGMPGRSW 74

  Fly   515 ------------------AVDPD-SGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKA 560
                              .|||: :.....||||.:.|:.|.|:|..|::|.|.|.||.:|||:.
Human    75 ASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLED 139

  Fly   561 DKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPI 625
            |.:..:.::..|||:|....:|.:........||..|::.:.|||.|.:|.|:.|.|..|:...:
Human   140 DAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDML 204

  Fly   626 EIQY----DDDQKLVKHESHFF----TSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGK 682
            ::.|    .|:::..|.||...    .|:|::.||.|||||.::.:|.:.:||...:..|.||||
Human   205 QMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGK 269

  Fly   683 LSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQML 747
            |:..||::.|:.:|:|.:.:..|.:...|::|.|.|||.|||:||::.|.||.|.:::.:..|:|
Human   270 LTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLL 334

  Fly   748 DSLAEIEVAYSIIKSEDVSDACNPLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYD 812
            ::|.:||:|..::|:| :....:|||.||..:...|..||..|.||.::|||:::|||.||..|.
Human   335 EALGDIEIAIKLVKTE-LQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYT 398

  Fly   813 LKIVDVFKVSRQGEARRFKPFKKLHNRKLLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGI 877
            :.::|:|:|.:.||...|:  :.||||.|||||||::|:||||||||||||||||.|||||||||
Human   399 MTLLDLFEVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGI 461

  Fly   878 YFADMVSKSANYCCTSQQNSTGLMLLSEVALGDMMECTSAK-YINKLSNNKHSCFGRGRTMPDPT 941
            |||||.|||||||..|:..:|||:||||||||...|...|. ....|...|||..|.|:..|. :
Human   462 YFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPS-S 525

  Fly   942 KSYIRSDGVEIPYGETITDEHLKS----SLLYNEYIVYDVAQVNIQYLFRMEFKY 992
            ..::..:|..:|.|.. :|..:.:    :|.|||||||:..||.::||.:::|.:
Human   526 AHFVTLNGSTVPLGPA-SDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 579

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.