DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Parp and parp3

DIOPT Version :9

Sequence 1:	NP_001104452.1	Gene:	Parp / 3355109	FlyBaseID:	FBgn0010247	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001120635.1	Gene:	parp3 / 100145803	XenbaseID:	XB-GENE-987109	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	187/550 - (34%)
Similarity:	297/550 - (54%)	Gaps:	56/550 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 GTDPKSRIPK-----ETTKSLNSNSIYTKSMPVSRTFKVKDGLA-VDPDSGLEDIA--HVYVDSN 533
            |.:.|:::.|     ||.:.:.:...:..::...:....|.|.| :|....|....  .||.|
Frog    15 GKNKKAKVKKEIKEEETEQPVKAPDRFQSAVQALKAASGKKGKAKIDSSCHLSSYGDYEVYED-- 77

  Fly   534 NKYSVVLGLTDIQRNKNSYYKVQLLKADKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFK 598
              |..:|..|:|..|.|.:|.:||:  .||.:|:.:..|||:| .:|.|||..|...|:|:::|:
Frog    78 --YDCMLNQTNIGSNNNKFYVIQLI--TKKNEYYCWNRWGRVG-EVGQSKLSPFPKLENAQKDFE 137

  Fly   599 EIYADKTGNEYEQRDNFVKRTGRMYPIEIQYDDD----QKLVKHESHFFT------SKLEISVQN 653
            :.:.|||.|.:.:|:||....|:...||:::|||    :..||.::...|      ..|:...|:
Frog   138 KKFKDKTKNSWSERENFTPHPGKYTIIEVEHDDDNGSGEATVKADTVDGTVQKVRPCSLDKPTQD 202

  Fly   654 LIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTAKLIDATNRF 718
            ||.|||..|...:.:...::|:.||||||||..||...:..:.|:...|:..:|...|.|.::||
Frog   203 LISLIFSTDMFKEAMQTMNLDIKKMPLGKLSKAQIAKGFEALDELQAALDRKANKGVLSDLSSRF 267

  Fly   719 YTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSI----IKSED----VSDACNPLDNH 775
            ||:||||||.:.|.:|:|.:.::..:.||..||:||:|.::    :|.|:    |.:..:|||..
Frog   268 YTIIPHNFGRRTPPVIDTSEVLQAKKDMLLVLADIELAQTLQADKVKKEEEEEKVQEVPHPLDVD 332

  Fly   776 YAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRK 840
            |..:|..|..||.::||:.::..||:|| ..|:::  |||.:|:.|:|:.|..||...|.:.||:
Frog   333 YELLKCDLSLLDTSTEEYKVIKTYVENT-GPTYRT--LKIQNVWCVNRETEEERFSAHKDIENRR 394

  Fly   841 LLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYC-CTSQQNSTGLMLLS 904
            |||||:.:...|.||..||||    .|.:|...|||||||...||||.|. |||:  :.|:|.|:
Frog   395 LLWHGTNIAVVVAILKSGLRI----MPHSGGRVGKGIYFASENSKSAGYVGCTSK--NLGIMFLN 453

  Fly   905 EVALG-----DMMECTSAKYINKLSNNKHSCFGRGRTMPDPTKS-YIRSDG--VEIPYGETI-TD 960
            |||||     .|.:|:    :........|...||.|.|:|.|. .:..||  :.:|.|..: .:
Frog   454 EVALGREHHIKMDDCS----LQSPPKGYDSVVARGLTEPEPAKDRKLDLDGRKITVPQGRPVKME 514

  Fly   961 EHLKSSLLYNEYIVYDVAQVNIQYLFRMEF 990
            ::..||...:||:||..:|..::||..::|
Frog   515 KYSDSSFGQSEYLVYKESQARMRYLLLLKF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parp	NP_001104452.1	PLN03123	6..992	CDD:215590	186/549 (34%)
		zf-PARP	10..83	CDD:279039
		zf-PARP	114..193	CDD:279039
		PADR1	270..322	CDD:285325
		BRCT	382..454	CDD:214602
		WGR_PARP1_like	526..629	CDD:153428	37/104 (36%)
		parp_like	645..988	CDD:238717	133/360 (37%)
parp3	NP_001120635.1	WGR_PARP3_like	70..168	CDD:153429	37/104 (36%)
parp3	NP_001120635.1	parp_like	193..543	CDD:238717	133/362 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920