DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and PEF1

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_011572.2	Gene:	PEF1 / 852949	SGDID:	S000003290	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	178	Identity:	53/178 - (29%)
Similarity:	83/178 - (46%)	Gaps:	5/178 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NHDGMPDQQFLWDVFQRVDKDRSGHISADELQVALSNGTWSAFNPETIRLMIGMFDRENKGTVSF 68
            :.:.:.|.|....:|...|......::|:|||..|.|...|.|...::..:|.:|.....|||:.
Yeast   152 SREDVRDMQVATQLFHNHDVKGKNRLTAEELQNLLQNDDNSHFCISSVDALINLFGASRFGTVNQ 216

  Fly    69 KDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGY----RLSDHLIDVLLRKFDRFGR 129
            .:|.||:|.|..|:..:...|.:.|..|..:|...:|...||    .:|:...|......:|.|.
Yeast   217 AEFIALYKRVKSWRKVYVDNDINGSLTISVSEFHNSLQELGYLIPFEVSEKTFDQYAEFINRNGT 281

  Fly   130 GTIL-FDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSMVFSL 176
            |..| ||.|::..:.|..||..||:.||:.:||.||.|:.|:.....|
Yeast   282 GKELKFDKFVEALVWLMRLTKLFRKFDTNQEGIATIQYKDFIDATLYL 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	15/54 (28%)
		EFh	16..71	CDD:238008	15/54 (28%)
		EF-hand_7	82..139	CDD:290234	16/61 (26%)
		EFh	85..139	CDD:238008	16/58 (28%)
PEF1	NP_011572.2	EFh_PEF_Group_I	161..329	CDD:320055	50/167 (30%)
		EF-hand motif	161..190	CDD:320055	8/28 (29%)
		EF-hand motif	198..227	CDD:320055	9/28 (32%)
		EF-hand motif	228..257	CDD:320055	6/28 (21%)
		EF-hand motif	264..298	CDD:320055	9/33 (27%)
		EF-hand motif	300..328	CDD:320055	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I1621
Isobase	1	0.950	-	0	Normalized mean entropy	S1635
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	1	1.000	-	-		oto100350
orthoMCL	1	0.900	-	-		OOG6_100410
Panther	1	1.100	-	-	LDO	PTHR46212
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910