DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and CAPNS1

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	XP_005259352.1	Gene:	CAPNS1 / 826	HGNCID:	1481	Length:	322	Species:	Homo sapiens

Alignment Length:	161	Identity:	47/161 - (29%)
Similarity:	82/161 - (50%)	Gaps:	11/161 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FQRVDKDRSG---HISADELQVALSNGT-------WSAFNPETIRLMIGMFDRENKGTVSFKDFG 72
            |:|:....:|   .:||.||...|:...       ...|..:|.|.|:.:.|.:..|.:.|::|.
Human   101 FRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFK 165

  Fly    73 ALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRGTILFDDF 137
            .||..:..||..::.||.|.||.|..:||..|..:.|:.|::||.::::|::.. ..|.:.||:|
Human   166 YLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSD-ESGNMDFDNF 229

  Fly   138 IQCCIVLYTLTTAFRQHDTDLDGIITIHYEQ 168
            |.|.:.|..:..||:..|.|..|.|.::.::
Human   230 ISCLVRLDAMFRAFKSLDKDGTGQIQVNIQE 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	15/62 (24%)
		EFh	16..71	CDD:238008	15/62 (24%)
		EF-hand_7	82..139	CDD:290234	19/56 (34%)
		EFh	85..139	CDD:238008	18/53 (34%)
CAPNS1	XP_005259352.1	EFh_PEF_CPNS1_2	100..260	CDD:320063	47/159 (30%)
		EF-hand motif	100..128	CDD:320063	8/26 (31%)
		EF-hand motif	142..172	CDD:320063	9/29 (31%)
		EF-hand motif	173..203	CDD:320063	11/29 (38%)
		EF-hand motif	209..237	CDD:320063	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920