DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and SRI

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_003121.1	Gene:	SRI / 6717	HGNCID:	11292	Length:	198	Species:	Homo sapiens

Alignment Length:	170	Identity:	67/170 - (39%)
Similarity:	96/170 - (56%)	Gaps:	7/170 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QQFLWDVFQRVDKDRSGHISADELQVALSN----GTWSAFNPETIRLMIGMFDRENKGTVSFKDF 71
            |..|:..|..| ..:.|.|.|||||..|:.    |.:..||.||.|||:.|.||:..||:.|.:|
Human    32 QDPLYGYFAAV-AGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 95

  Fly    72 GALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRGTILFDD 136
            ..||..:..|:..|.|||.|.||.:|..||:.|||:.|:|||...::.:.:::..  .|.|.|||
Human    96 KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYST--NGKITFDD 158

  Fly   137 FIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSMVFSL 176
            :|.||:.|..||.:||:.||...|::...|:.|:..|.|:
Human   159 YIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	24/58 (41%)
		EFh	16..71	CDD:238008	24/58 (41%)
		EF-hand_7	82..139	CDD:290234	22/56 (39%)
		EFh	85..139	CDD:238008	22/53 (42%)
SRI	NP_003121.1	EFh_PEF_sorcin	34..198	CDD:320062	65/166 (39%)
		EF-hand motif	34..62	CDD:320062	11/28 (39%)
		EF-hand motif	74..103	CDD:320062	13/28 (46%)
		EF-hand motif	104..133	CDD:320062	14/28 (50%)
		EF-hand motif	140..167	CDD:320062	8/28 (29%)
		EF-hand motif	169..197	CDD:320062	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54126
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100410
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830