DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and capn2b

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001018177.1	Gene:	capn2b / 563053	ZFINID:	ZDB-GENE-050522-84	Length:	696	Species:	Danio rerio

Alignment Length:	168	Identity:	45/168 - (26%)
Similarity:	81/168 - (48%)	Gaps:	18/168 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PDQQF----LWDVFQRVDKDRSGHISADELQVALSNGTWSAFNPETIRLMIGMFDRENKGTVSFK 69
            ||.:.    |..:|.::...|:...|             |.|..:|.|:|:.:.|....|.:...
Zfish   540 PDMEISPLELMTIFNKIIAKRTDIKS-------------STFTLDTCRVMVNLMDDSGNGKLGLG 591

  Fly    70 DFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRGTILF 134
            :|..|||.|..:...|:..|.|:||.|...||:.||...|:.|::.|..:::.::..... |:||
Zfish   592 EFATLWKKVQRYLEIFKHNDLDSSGTISTPELRMALKEAGFCLNNTLFQLMVARYAEKDM-TLLF 655

  Fly   135 DDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSM 172
            |:|:.|.:.|..:..||::.|....|.|.:::.|:|::
Zfish   656 DNFVSCLMRLEMMFRAFKRLDPHKSGFIELNFNQWLNL 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	10/54 (19%)
		EFh	16..71	CDD:238008	10/54 (19%)
		EF-hand_7	82..139	CDD:290234	18/56 (32%)
		EFh	85..139	CDD:238008	18/53 (34%)
capn2b	NP_001018177.1	Peptidase_C2	46..339	CDD:279042
		Calpain_III	354..503	CDD:279416
		EFh	573..628	CDD:238008	18/54 (33%)
		FRQ1	601..>686	CDD:227455	25/85 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910