DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and pef1

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001003643.1	Gene:	pef1 / 445249	ZFINID:	ZDB-GENE-040801-259	Length:	270	Species:	Danio rerio

Alignment Length:	166	Identity:	69/166 - (41%)
Similarity:	98/166 - (59%)	Gaps:	3/166 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GMPDQQFLWDVFQRVDKDRSGHISADELQVALSNGTWSAFNPETIRLMIGMFDRENKGTVSFKDF 71
            |:..:.:.|  |..||.|:||:|:|.||:.||.|...|:||.||..:|:.|||:...|.|....|
Zfish   100 GVNPEAYQW--FSTVDSDQSGYINAKELKQALMNFNNSSFNDETCIMMLNMFDKTKSGRVDVFGF 162

  Fly    72 GALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFD-RFGRGTILFD 135
            .|||.::..|:..|:.||||.||:|:..|:..||:..||.||...|..|:.::. |.|.|.:..|
Zfish   163 SALWTFLQQWRAAFQQFDRDRSGSINTNEMHQALSQMGYNLSPQFIQELVNRYSVRGGTGVLQLD 227

  Fly   136 DFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLS 171
            .|||.|..|.::|.|||:.||.:.|.:.:.||.|||
Zfish   228 RFIQVCTQLQSMTQAFREKDTGMTGNVRMSYEDFLS 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	24/54 (44%)
		EFh	16..71	CDD:238008	24/54 (44%)
		EF-hand_7	82..139	CDD:290234	22/57 (39%)
		EFh	85..139	CDD:238008	22/54 (41%)
pef1	NP_001003643.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		5 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P	22..91
		EFh	109..167	CDD:238008	27/57 (47%)
		EF-hand_7	109..165	CDD:290234	25/55 (45%)
		EF-hand_7	173..233	CDD:290234	24/59 (41%)
		EFh	173..231	CDD:238008	22/57 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54126
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100410
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1327
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830