DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and capn1

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_998624.1	Gene:	capn1 / 406768	ZFINID:	ZDB-GENE-040426-2814	Length:	704	Species:	Danio rerio

Alignment Length:	180	Identity:	48/180 - (26%)
Similarity:	94/180 - (52%)	Gaps:	16/180 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MPDQQFLWDV-----FQRVDKDRSG---HISADELQVALS-------NGTWSAFNPETIRLMIGM 57
            :|::|.|.:.     |:.:.:..:|   .||..|||..|:       :.....|..|:.|.||.:
Zfish   522 IPEEQRLDESQIDAGFKSLFRQLAGADMEISVTELQTILNRIIAKHKDLKTDGFGKESCRSMINL 586

  Fly    58 FDRENKGTVSFKDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLR 122
            .|.:..|.:...:|..||:.:..:...||..|.|.||.:...|::.||.:.|::|::||..:::.
Zfish   587 VDTDGSGKLGLVEFHVLWEKIKRYLQIFRDHDVDKSGTMSSYEMRKALETAGFKLNNHLFQLIIL 651

  Fly   123 KFDRFGRGTILFDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSM 172
            ::..... ::.||:|:.|.:.|.|:...|:..|||.||:|::.:.|::::
Zfish   652 RYTEEDL-SVDFDNFVSCLVRLETMFKTFKSLDTDADGVISLTFFQWITL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	15/69 (22%)
		EFh	16..71	CDD:238008	15/69 (22%)
		EF-hand_7	82..139	CDD:290234	16/56 (29%)
		EFh	85..139	CDD:238008	16/53 (30%)
capn1	NP_998624.1	Peptidase_C2	51..347	CDD:279042
		Calpain_III	361..509	CDD:279416
		EF-hand_8	547..606	CDD:290545	16/58 (28%)
		EFh	580..634	CDD:238008	15/53 (28%)
		EF-hand_7	612..698	CDD:290234	27/86 (31%)
		EFh	613..692	CDD:298682	26/79 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910