DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and Capn13

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001028616.1	Gene:	Capn13 / 381122	MGIID:	2685789	Length:	665	Species:	Mus musculus

Alignment Length:	162	Identity:	39/162 - (24%)
Similarity:	69/162 - (42%)	Gaps:	13/162 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DRSGHISADELQVA-----LSNGTWSAFNPETIRLMIGMFDRENKGTVSFKDFGALWKYVTDWQN 83
            |:...|.|.:||..     |:......|:.:..:.::.:.|.:..|.:..::|..|...:...|:
Mouse   507 DQGLDIDATQLQSLLNQEFLTGPPGDTFSLDQCQSIMALMDLKVNGRLDQEEFARLRSRLIHCQH 571

  Fly    84 CFRSFDRDNSGNIDKTELKTAL--TSF--GYRLSDHLIDVL-LRKFDRFGRGTILFDDFIQCCIV 143
            .|:|..| ..|.:..::|...:  |.|  |..:|..|:.:: ||..|..||  :.|...:...|.
Mouse   572 IFQSIQR-RPGVLLSSDLWKVIENTDFLVGIFISSELLSLMALRYSDSSGR--VSFPTLVCFLIR 633

  Fly   144 LYTLTTAFRQHDTDLDGIITIHYEQFLSMVFS 175
            |.|:..|||....|..||.....|....:::|
Mouse   634 LETMAKAFRNLSKDGKGIYLTETEWMNLVMYS 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	9/51 (18%)
		EFh	16..71	CDD:238008	9/51 (18%)
		EF-hand_7	82..139	CDD:290234	17/61 (28%)
		EFh	85..139	CDD:238008	16/58 (28%)
Capn13	NP_001028616.1	Peptidase_C2	31..327	CDD:279042
Capn13	NP_001028616.1	Calpain_III	343..469	CDD:294111
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910