DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and CalpA

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	169	Identity:	49/169 - (28%)
Similarity:	88/169 - (52%)	Gaps:	18/169 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GMPDQQFLWDVFQRVDKDR---SGHISADELQVALSNGTWSAFNPETIRLMIGMFDRENKGTVSF 68
            ||.||.     .:|:..|.   .|.::|:.: |..::|    |:.:..|.|:.|.|.:..|.:.|
  Fly   682 GMNDQS-----NKRLIGDNPADGGPVTANAI-VDETHG----FSKDVCRSMVAMLDADKSGKLGF 736

  Fly    69 KDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGR--GT 131
            ::|..|...:..|:..|:.:|.:|:|.:...:|:.||.|.||.|::.:::||   ..|:|.  |.
  Fly   737 EEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVL---GHRYGSRDGK 798

  Fly   132 ILFDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFL 170
            |.|||||.|.:.:.|....|::.||:.:...|...|:::
  Fly   799 IAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	13/57 (23%)
		EFh	16..71	CDD:238008	13/57 (23%)
		EF-hand_7	82..139	CDD:290234	21/58 (36%)
		EFh	85..139	CDD:238008	21/55 (38%)
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416
		EFh	719..765	CDD:238008	13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840