DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and Capn1

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_062025.1	Gene:	Capn1 / 29153	RGDID:	2267	Length:	713	Species:	Rattus norvegicus

Alignment Length:	184	Identity:	51/184 - (27%)
Similarity:	94/184 - (51%)	Gaps:	24/184 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MPDQQFLW-----DVFQRVDKDRSG---HISADELQVAL-----------SNGTWSAFNPETIRL 53
            :||::.|.     |.|:.:....:|   .||..|||..|           :||    |:.|:.|.
  Rat   531 LPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNG----FSLESCRS 591

  Fly    54 MIGMFDRENKGTVSFKDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLID 118
            |:.:.||:..|.:...:|..||..:.::...||.||.|.||::...|::.|:.:.|::|:..|.:
  Rat   592 MVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHE 656

  Fly   119 VLLRKFDRFGRGTILFDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSM 172
            :::.::..... .:.||:|:.|.:.|.|:...|:..||||||::|....::|.:
  Rat   657 LIITRYSEPDL-AVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	18/68 (26%)
		EFh	16..71	CDD:238008	18/68 (26%)
		EF-hand_7	82..139	CDD:290234	15/56 (27%)
		EFh	85..139	CDD:238008	15/53 (28%)
Capn1	NP_062025.1	Peptidase_C2	56..352	CDD:279042
		Domain III	355..525
		Calpain_III	366..518	CDD:279416
		Linker	526..541		3/9 (33%)
		PTZ00184	537..680	CDD:185504	38/147 (26%)
		Domain IV	542..712		48/173 (28%)
		EF-hand_8	556..609	CDD:290545	15/56 (27%)
		EFh	589..643	CDD:238008	16/53 (30%)
		EFh	622..704	CDD:298682	26/82 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910