DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and GCA

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	XP_006712461.1	Gene:	GCA / 25801	HGNCID:	15990	Length:	259	Species:	Homo sapiens

Alignment Length:	158	Identity:	56/158 - (35%)
Similarity:	88/158 - (55%)	Gaps:	17/158 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RSGHISADELQVALS----NGTWSAFNPETIRLMIGMFDRENKGTVSFKDFGALWKYVTDWQNCF 85
            :.|.:.|:|||..|:    |||:|.|:.||.|:||.|.||::.|.:.|..|..||..:..|:..|
Human    90 QDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENF 154

  Fly    86 RSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRGTILFDDFIQCCIVLYTLTTA 150
            .:.|:|.||.::..||:.|:...|||||...:..:::::.:.||  |.|||::.||:.|..||..
Human   155 MTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGR--IFFDDYVACCVKLRALTDF 217

  Fly   151 FRQHD-----------TDLDGIITIHYE 167
            ||:.|           .|..|:..|::|
Human   218 FRKRDHLQQGSANFIYDDCGGMNVINFE 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	21/49 (43%)
		EFh	16..71	CDD:238008	21/49 (43%)
		EF-hand_7	82..139	CDD:290234	19/56 (34%)
		EFh	85..139	CDD:238008	19/53 (36%)
GCA	XP_006712461.1	EFh	90..145	CDD:298682	23/54 (43%)
		EFh	120..174	CDD:298682	19/53 (36%)
		EF-hand_7	151..206	CDD:290234	19/56 (34%)
		EFh	151..206	CDD:298682	19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54126
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100410
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830