DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg-2 and gca

DIOPT Version :9

Sequence 1:	NP_001104459.2	Gene:	Alg-2 / 3355106	FlyBaseID:	FBgn0086378	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001119547.1	Gene:	gca / 100125139	XenbaseID:	XB-GENE-983090	Length:	203	Species:	Xenopus tropicalis

Alignment Length:	176	Identity:	61/176 - (34%)
Similarity:	99/176 - (56%)	Gaps:	11/176 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HDGMPDQQFLWDVFQRVDKDRSGHISADELQVALS----NGTWSAFNPETIRLMIGMFDRENKGT 65
            |:|.|    ||..|:.| ..:.|.|.|:|||..|:    .||::.|:.||.|::|.|.||:..|.
Frog    35 HEGDP----LWGYFRAV-AGQDGEIDAEELQRCLTQAGIQGTYTPFSLETCRVLIAMLDRDFTGK 94

  Fly    66 VSFKDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRG 130
            :.|.:|..:|..::.|:..|.:||:|.||.::..||..|:.:.|||||...:..:::::.:.||
Frog    95 MGFSEFKEVWGALSAWKQNFCTFDQDRSGTVEPHELNQAIFAMGYRLSPPTLSTIVKRYSKNGR- 158

  Fly   131 TILFDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSMVFSL 176
             |.|||::.||:.|..||..||:.|....|.:...|:.||....::
Frog   159 -IYFDDYVACCVKLRALTDVFRRRDGMQQGFVNFIYDDFLQCTMAI 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg-2	NP_001104459.2	EF-hand_7	16..71	CDD:290234	21/58 (36%)
		EFh	16..71	CDD:238008	21/58 (36%)
		EF-hand_7	82..139	CDD:290234	20/56 (36%)
		EFh	85..139	CDD:238008	20/53 (38%)
gca	NP_001119547.1	EFh_PEF_grancalcin	39..203	CDD:320061	59/170 (35%)
		EF-hand motif	39..67	CDD:320061	12/32 (38%)
		EF-hand motif	79..108	CDD:320061	10/28 (36%)
		EF-hand motif	109..139	CDD:320061	10/29 (34%)
		EF-hand motif	145..172	CDD:320061	8/28 (29%)
		EF-hand motif	173..203	CDD:320061	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54126
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930