DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12567 and YJR142W

DIOPT Version :9

Sequence 1:	NP_001015384.1	Gene:	CG12567 / 3355094	FlyBaseID:	FBgn0039958	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_012676.3	Gene:	YJR142W / 853607	SGDID:	S000003903	Length:	342	Species:	Saccharomyces cerevisiae

Alignment Length:	302	Identity:	92/302 - (30%)
Similarity:	160/302 - (52%)	Gaps:	25/302 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QKFNNFYLSGIHKCDIRPFVVEGKQVGLIKSDVLKHLEKYPEVFCIRACEQTKQ---GLVELNPA 77
            :.:.||.....:.|     ..:|.::|.    |||......|..|....|:|.|   ...||...
Yeast    41 ENYKNFKEGIYYMC-----THDGTKIGF----VLKFAINEMETVCSEIFEETFQLDESRHELRFK 96

  Fly    78 FRDYNERTEQLEKVLRNLRSEGLFPALQGWRDEYFEVKADCRALLKMERAATPLFGVRKYGVDIN 142
            ..|::.|...::::.|.:..|.....::|||:|.:.|..:.:..:.:|||...:.|:..||:.||
Yeast    97 SEDFDHRNNLIDQLARKMYLESSLSGVKGWRNEKYAVWVNKKPYVLVERAVAGVLGIITYGIHIN 161

  Fly   143 GYVRHP-TLGLCIWLQQRSNTKETWPGKWDNMVGGGLSVGFGIKETAIKEAAEEASIPSDLVK-N 205
            |||..| :..:..|:.:||.||:|||...||::.|||...:||.||.:||:.|||::...::: |
Yeast   162 GYVLDPKSKKVQFWVPRRSKTKQTWPLMLDNIIAGGLGYPYGIYETVLKESMEEANLEKSVIEDN 226

  Fly   206 LVSAGCVSF-YF----------ESRQGLFPNTEYVFDLELPLDFVPQNADGEVQAFELLTAKDCV 259
            :.:.|.||: ||          :....:....:||:||:|..|.:|:..||||::|.|.:.::.:
Yeast   227 IKATGSVSYLYFTGDISVTKFNKESDFIVGEVQYVYDLKLSEDIIPKPNDGEVESFNLFSLQETI 291

  Fly   260 ERVFTSDFKTTSAPVVIDFLIRHGHITADDVVDFTQIVELLH 301
            ..:...:||...|.|::|||||||:||.::..::.::|..:|
Yeast   292 NALRKKEFKPNCALVMVDFLIRHGYITPENEPNYLELVTRMH 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12567	NP_001015384.1	DUF4743	11..136	CDD:292538	28/122 (23%)
CG12567	NP_001015384.1	Nudix_hydrolase_3	106..283	CDD:239648	67/189 (35%)
YJR142W	NP_012676.3	DUF4743	<80..153	CDD:406365	17/72 (24%)
YJR142W	NP_012676.3	Nudix_hydrolase_3	125..315	CDD:239648	67/189 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343756
Domainoid	1	1.000	80	1.000	Domainoid score	I2026
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6313
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1092
Isobase	1	0.950	-	0	Normalized mean entropy	S12659
OMA	1	1.010	-	-		QHG58027
OrthoFinder	1	1.000	-	-		FOG0006046
OrthoInspector	1	1.000	-	-		oto99130
orthoMCL	1	0.900	-	-		OOG6_104807
Panther	1	1.100	-	-	LDO	PTHR13622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16873
SonicParanoid	1	1.000	-	-		X4339
TreeFam	1	0.960	-	-
	16	15.740