DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12567 and tpk2

DIOPT Version :9

Sequence 1:	NP_001015384.1	Gene:	CG12567 / 3355094	FlyBaseID:	FBgn0039958	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001038862.1	Gene:	tpk2 / 751683	ZFINID:	ZDB-GENE-060503-173	Length:	297	Species:	Danio rerio

Alignment Length:	310	Identity:	125/310 - (40%)
Similarity:	174/310 - (56%)	Gaps:	25/310 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSTEVKLSRLLILAQKFNNFYLSG--IHKCDIRPFVVEGKQVGLIKSDVLKHLEKYPEVF---- 59
            |:|...|:.:||   ::.|||:|.|  :..| :| |.|.|:|||.|...|...|.::|.||
Zfish     1 MASWSEKMLQLL---RRMNNFHLPGSILESC-LR-FEVAGEQVGWISPKVASVLGRFPSVFRPYG 60

  Fly    60 -CIRACEQTKQGLVELNPAFRDYNERTEQLEKVLRNLRSEGLFPALQGWRDEYFEVKAD-C-RAL 121
             .|..|.           :...:..|:..:::||:.||.|..|..|.|||||.:.|... | ..|
Zfish    61 SAITFCS-----------SLDTFASRSVAVDEVLQELRREASFTCLIGWRDEQYAVMPRYCDPPL 114

  Fly   122 LKMERAATPLFGVRKYGVDINGYVRHPTLGLCIWLQQRSNTKETWPGKWDNMVGGGLSVGFGIKE 186
            :.||||||.||||::|||.:|||.|..:..|.:||.:||.||:|:||:.|||..|||:.|..::.
Zfish   115 MYMERAATSLFGVKRYGVHVNGYTRDSSGNLNMWLARRSLTKQTYPGRLDNMAAGGLAAGCSVRH 179

  Fly   187 TAIKEAAEEASIPSDLVKNLVSAGCVSFYFESRQGLFPNTEYVFDLELPLDFVPQNADGEVQAFE 251
            |.:||..|||.||..|.:.....|.||:.:|..:|:||..::||||||||:|.|...|||||||.
Zfish   180 TMVKECEEEACIPPGLAEQARPVGTVSYTYEDDEGIFPECQFVFDLELPLNFQPHIGDGEVQAFY 244

  Fly   252 LLTAKDCVERVFTSDFKTTSAPVVIDFLIRHGHITADDVVDFTQIVELLH 301
            ....:...:.:.:.:||...|.||:||||||..|..|....:.:.|..||
Zfish   245 YYPIEKVKDLLVSEEFKPNCAMVVLDFLIRHAIIEPDSEPYYHEFVAGLH 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12567	NP_001015384.1	DUF4743	11..136	CDD:292538	49/133 (37%)
CG12567	NP_001015384.1	Nudix_hydrolase_3	106..283	CDD:239648	85/178 (48%)
tpk2	NP_001038862.1	DUF4743	8..129	CDD:292538	49/136 (36%)
tpk2	NP_001038862.1	Nudix_hydrolase_3	97..275	CDD:239648	84/177 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580500
Domainoid	1	1.000	108	1.000	Domainoid score	I6396
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6313
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3692
OMA	1	1.010	-	-		QHG58027
OrthoDB	1	1.010	-	-		D1114442at2759
OrthoFinder	1	1.000	-	-		FOG0006046
OrthoInspector	1	1.000	-	-		oto40599
orthoMCL	1	0.900	-	-		OOG6_104807
Panther	1	1.100	-	-	LDO	PTHR13622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16873
SonicParanoid	1	1.000	-	-		X4339
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800