DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12567 and Nudt19

DIOPT Version :9

Sequence 1:	NP_001015384.1	Gene:	CG12567 / 3355094	FlyBaseID:	FBgn0039958	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_149071.2	Gene:	Nudt19 / 110959	MGIID:	94203	Length:	357	Species:	Mus musculus

Alignment Length:	380	Identity:	70/380 - (18%)
Similarity:	123/380 - (32%)	Gaps:	135/380 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLLILAQKFNNFYLSGIH--------KCDIRPFVVE-------------GKQ-------VGLIKS 46
            |||:|.:..|..:|.|.|        ..|..|..|.             |.:       .||...
Mouse    28 RLLLLQRAQNQRFLPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHG 92

  Fly    47 DVLKHLEKYPEVFCIRAC---EQTKQ-GLVELNPAFRDYNERTEQLEKVLRNLRSEGLFP--ALQ 105
            |.  .....|:...:|.|   |..:: |::.|.|  ||....:::        .|:.|.|  .|.
Mouse    93 DA--DPAALPDDVALRICAIREAFEEAGVLLLRP--RDAAPASQE--------PSQALSPPAGLA 145

  Fly   106 GWRDEYFEVKADCRALLKM--ERAATP-LFGVRKYGVDINGYVR-----HPTLGLCI-------- 154
            .||.   .|::|.|..|::  ....|| ::.:..:|..:..|.|     ..|..||.
Mouse   146 EWRS---RVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRTIRRFDTTFFLCCLRDIPRVE 207

  Fly   155 ----------WLQQRSNT-----KETW--PGKWDNMVGGGLSVGFGIKETAIKEAAEEASIPSDL 202
                      ||.....|     ||.|  |.::..|                           ..
Mouse   208 PDVAEVVGYQWLSPSEATECFLSKEIWLAPPQFYEM---------------------------RR 245

  Fly   203 VKNLVSAGCVSFYFESRQGLFPNTEYVFDLELPLDFVP---QNADGEVQAF---EL-LTAKDCVE 260
            ::|..|...:..:...|..           |:|..::|   ..:||.:...   || :...|.:|
Mouse   246 LENFASLSALYRFCSDRPS-----------EVPEKWLPIILLTSDGTIHLLPGDELYVKDSDFLE 299

  Fly   261 RVFTSDFKTTSAPVVIDFLIRHGHITADDVVDFTQIVEL-LHVPLQSIYTYKTRF 314
            :..::|.||       :.:::.|.:....|:....:.|: :.:|.::.:.|...:
Mouse   300 KNMSTDKKT-------EEIVKEGKVLNRVVIHSPYVYEIYMTLPSENKHVYPRNY 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12567	NP_001015384.1	DUF4743	11..136	CDD:292538	35/161 (22%)
CG12567	NP_001015384.1	Nudix_hydrolase_3	106..283	CDD:239648	37/216 (17%)
Nudt19	NP_149071.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93		3/20 (15%)
		Nudix box	97..118		4/20 (20%)
		Microbody targeting signal. /evidence=ECO:0000255	355..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900