DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and AAP1

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	959	Identity:	205/959 - (21%)
Similarity:	385/959 - (40%)	Gaps:	187/959 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSK---------KVYFHAHDTLLIDVSQIN 108
            ||..|.||.|::.:||:.....||||:::.|: |.|..         ::.||:.....::..::|
Yeast     6 LPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQ-INDHSINSVQINYLEIDFHSARIEGVNAIEVN 69

  Fly   109 ------LTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEG 167
                  ..||...:||.:                         ..|....|:|.|.|.:::...|
Yeast    70 KNENQQKATLVFPNGTFE-------------------------NLGPSAKLEIIFSGILNDQMAG 109

  Fly   168 LFRSYYTNSGNDGEEIYLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHN- 230
            .:|:.||:... ||..|:| |.::..:|||.|||||||.:|..|.|::........|.|..:.|
Yeast   110 FYRAKYTDKVT-GETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNE 173

  Fly   231 TINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSD--IPAINIWSNNLSSTNLL 293
            ||...|  .|:.  |:||..|||:...|::..|      :.|:|::  || :.::|   :..:..
Yeast   174 TIKEGK--KYTT--FNTTPKMSTYLVAFIVADL------RYVESNNFRIP-VRVYS---TPGDEK 224

  Fly   294 DIQNKLNVAHTTIQHF---FNIPLPLTKLDVIAIPSLAT-----------------LPFISASGI 338
            ..|...|:|..|::.|   |||..||.|:|::|:...:.                 |...::|..
Yeast   225 FGQFAANLAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLD 289

  Fly   339 LIARESEILKKDVFEISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIEFNGKY 403
            .|.|.:|:       |..||.:||.|..:|.:||....:|:...::::   .:..|   :|..::
Yeast   290 RIQRVAEV-------IQHELAHQWFGNLVTMDWWEGLWLNEGFATWMS---WYSCN---KFQPEW 341

  Fly   404 PMTILY------------SLYYELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKYTFR 453
            .:...|            ||........|.::...|...|.:|   |...::||:|..:|:.||.
Yeast   342 KVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFI 406

  Fly   454 LGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSE 518
            .|:..::..:|:...|:.|.|:|:...:..|        :.|:...|.:....|::: ::::.::
Yeast   407 KGVSQYLNKFKYGNAKTGDLWDALADASGKD--------VCSVMNIWTKRVGFPVLS-VKEHKNK 462

  Fly   519 TAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLPS---- 579
            ..:.|.: ||  ...||.::::...: ||.|..:||....||            |:.|..|
Yeast   463 ITLTQHR-YL--STGDVKEEEDTTIY-PILLALKDSTGIDNT------------LVLNEKSATFE 511

  Fly   580 -KN-MFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNF 642
             || .|..:|.::.|.|..:|.|..|..|||      :...:.|..|..|:.||..|:.:|..:.
Yeast   512 LKNEEFFKINGDQSGIFITSYSDERWAKLSK------QANLLSVEDRVGLVADAKALSASGYTST 570

  Fly   643 STALNVTLFLKYERNHIVWSPVFTFLDQVGKR--LEKSSINKKFELYIIELLAPLYEYLGTAHFN 705
            :..||:....|.|.:.:||..:...|..:...  .|...|....:.:.::|:......||. :..
Yeast   571 TNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGW-NIG 634

  Fly   706 ED--INITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMKE 768
            ||  ..|..|:....|..|.:|.......|...|..:.|.:    :..:|..:...:|...:...
Yeast   635 EDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGN----KQAIPALFKAVVFNTVARLG 695

  Fly   769 WMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVT 833
            .....:::....::.:.|:               :||..|..|...::..:...|...|:..||.
Yeast   696 GENNYEKIFNIYQNPVSSE---------------EKIIALRALGRFEDKELLERTLSYLLDGTVL 745

  Fly   834 SRSI------------GYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKK 886
            ::..            |...|..::..:||:|..:....:.:...:::.....|::.|..:.:..
Yeast   746 NQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISA 810

  Fly   887 FYDEHY--GHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYLSD 933
            ||....  |.    ...:.::|..|:...||..::..::..::..:..|
Yeast   811 FYSRKVTKGF----DQTLAQALDTIRSKAQWVSRDREIVATYLREHEYD 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	118/496 (24%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	59/339 (17%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	204/946 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910