DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and AOPEP

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001372995.1	Gene:	AOPEP / 84909	HGNCID:	1361	Length:	859	Species:	Homo sapiens

Alignment Length:	807	Identity:	139/807 - (17%)
Similarity:	259/807 - (32%)	Gaps:	275/807 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YICSSMASGTRTLFILTI--------------LLTAPGLEAFVNDFSSLHVISEV---RLPKEVL 58
            |.|.:...|:.. |:|.:              :...||||.|... ..|.|:||.   ::.:|::
Human   130 YCCDTGNHGSED-FLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRS-PELTVVSEEFRNQIVRELV 192

  Fly    59 PLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAH-------DTLLIDVSQINLTTLNMGD 116
            .|...                    ||   .:::.::|.       ..||.|....:|.....|.
Human   193 TLPAN--------------------RW---REQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGA 234

  Fly   117 GTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGE 181
            .|.......:|           ::.|.|                    .||  ||....|...|.
Human   235 QTATDFPHAIR-----------IWYKTK--------------------PEG--RSVTWTSDQSGR 266

  Fly   182 E-IYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKL-RSYSLDF 244
            . :|  |...|.|.|.||||.:.|.....:..::.....::.|.:.  .|:....:| ...|..:
Human   267 PCVY--TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSG--ENSAKPTQLWEECSSWY 327

  Fly   245 FHTTAPMSTHAFGFVI-----LKLHMWNEHKIV-------KSSDIPAINIWSN--------NLSS 289
            ::.|.||....|...:     :|:..|:.:.:.       ..::...:.:.|:        |.|:
Human   328 YYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASA 392

  Fly   290 TNLLDIQNK----------------------LNVAHTTI-QHFFNIPLPLTKLDVIAIPSLATLP 331
            |....|.::                      |:.||:.: .|      |.::|||:.:|  |..|
Human   393 TTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAH------PFSRLDVLIVP--ANFP 449

  Fly   332 FISASG--ILIARESEILKKDVF---EISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVF 391
            .:..:.  |:...:|.:...:..   .:..|:.:.|.|:.|....||:..:::...:.:  |.||
Human   450 SLGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHL--EDVF 512

  Fly   392 EINGG--IEFNGKYPMTILYSLYY------------ELSKRYPNSHITG---------IKH---- 429
            .....  ..:..:....:...|.:            |:....|:...||         |||
Human   513 WATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNP 577

  Fly   430 -----EFASIKVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDS 489
                 :...:|...::|.|:..:|..|:...::.|:..:..:...|.||...:......:..|
Human   578 EKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRL-- 640

  Fly   490 DLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDS 554
            :||:.:|.:.|||.|.:|                 |...|||....          ...|.||
Human   641 ELSVENIYQDWLESSGIP-----------------KPLQRERRAGA----------ECGLARQ-- 676

  Fly   555 LSFVNTGSFKWMNKTR-----------QMLISNLPSKNMFI---IVNEEEIGP---------FPV 596
               |.....||:...|           ::....||.:.:.:   ::.::.:.|         :.:
Human   677 ---VRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHL 738

  Fly   597 NYDD----NNW-------------NMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFST 644
            ...|    :.|             ..:.::|:.:::|.....:.|..|   ||          .|
Human   739 QDQDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQERPQQDSFIRLLL---AW----------GT 790

  Fly   645 ALNVTLFLKYERNHIVW-------SPV 664
            .|.:||.:|   ..|:|       |||
Human   791 RLELTLDIK---GGIMWLLKPSAHSPV 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	89/531 (17%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	19/117 (16%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	77/456 (17%)
		Nucleolar localization signal. /evidence=ECO:0000250\|UniProtKB:Q8BXQ6	689..699		1/9 (11%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	4/49 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900