DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and APM1

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	209/962 - (21%)
Similarity:	402/962 - (41%)	Gaps:	190/962 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNM 114
            |.||||..:|..|::.:.|.:....|.|::.:.|..:.|::.:..:|.|..:.|.| ::.|..:.
plant     7 EPRLPKFAVPKRYDLRLNPDLIACTFTGTVAIDLDIVADTRFIVLNAADLSVNDAS-VSFTPPSS 70

  Fly   115 GDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGND 179
            ........|::..     ...:.||...:.:..|.. :|.:.|.|.:::..:|.:||.|.::|.
plant    71 SKALAAPKVVLFE-----EDEILVLEFGEILPHGVG-VLKLGFNGVLNDKMKGFYRSTYEHNGE- 128

  Fly   180 GEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTP-LHNTIN-HPKLRSYSL 242
             ::....|..:|.:|||.|||:|||..|..|.:::..|...:.|.|.| :...:| :.|:.||.
plant   129 -KKNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIMEEKVNGNLKIVSYQ- 191

  Fly   243 DFFHTTAP-MSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNK--LNVAHT 304
                 .:| |||:....|:.......:|    :||...:.::    ......| |.|  |:|...
plant   192 -----ESPIMSTYLVAIVVGLFDYVEDH----TSDGIKVRVY----CQVGKAD-QGKFALHVGAK 242

  Fly   305 TI---QHFFNIPLPLTKLDVIAIPSLATLPFISASGILIARESEIL-----------KKDVFEIS 355
            |:   :.:|.:|.||.|:|:||||..|. ..:...|::..||:.:|           ::....::
plant   243 TLDLFKEYFAVPYPLPKMDMIAIPDFAA-GAMENYGLVTYRETALLYDEQHSAASNKQRVATVVA 306

  Fly   356 RELIYQWIGIWITPEWWTDANVNKAL---ISFIASEIVF-----------EINGGIEFNGKYPMT 406
            .||.:||.|..:|.||||...:|:..   :|::|::.:|           |...|:..:|
plant   307 HELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGLRLDG----- 366

  Fly   407 ILYSLYYELSKRYP----NSHITGIKHEFASI---KVQLIIRMLSLTVGKYTFRLGIQSFICDYK 464
                    |.:.:|    .:|...|...|.:|   |...:||||...:|...|:..:.::|.::.
plant   367 --------LEESHPIEVEVNHAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHA 423

  Fly   465 FKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTI-IRDYDSETAIVQQKVYL 528
            :...|:.|.|.|:        ...|...:..:..||.:....|:|:. |:|...|   ::|..:|
plant   424 YSNAKTEDLWAAL--------EAGSGEPVNKLMSSWTKQKGYPVVSAKIKDGKLE---LEQSRFL 477

  Fly   529 RERLHDVPDQDNMLWWIPIAL------KRQDSLSFVNTGSFKWMNKTRQMLISNLPSKN------ 581
            ..   ..|.:..  |.:|:.|      ||::.|....:|::    ..:::|..::...:
plant   478 SS---GSPGEGQ--WIVPVTLCCGSYEKRKNFLLESKSGAY----DLKELLGCSIADGSDKINGT 533

  Fly   582 -MFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTA 645
             .:|.:|.::.|.:.|.|||:    |:..||...:.:|:....|..:|.|::.|..|.:.:.::.
plant   534 CSWIKINVDQAGFYRVKYDDS----LAAGLRNATESQSLTSIDRYGILDDSFALTMARQQSLASL 594

  Fly   646 LNVTLFLKYERNHIVWSPVFTFLDQVGK-----RLEKSSINKKFELYIIELLAPLYEY---LGTA 702
            |.:....|.|.::.|.|.:.....:|.|     ..|..|..|.|.:.:.:..|....:   .|.:
plant   595 LTLCSAYKKELDYTVLSNLIAISYKVVKIGADANQELMSGIKHFFIGVFQFAAGKLGWDPKQGES 659

  Fly   703 HFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPV--PN----EYICSIF 761
            |.:     ..||....:.|...|:....|||.|.|:.::    .:..||:  |:    .|:..:.
plant   660 HLD-----AMLRGEVLTALAVFGHDETLKEAVRRFDAFL----ADRNTPLLPPDIRRAAYVAVMQ 715

  Fly   762 KWGSMKEWMFGLDRLCE-FPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNI--SIFSD- 822
            :  :.|....|.:.|.. :.::.:..::|.:|..||.||          :..|::::  .:.||
plant   716 R--ANKSDKSGYESLLRVYRETDLSQEKTRILGSLASCP----------DPTIVQDVLNFVLSDE 768

  Fly   823 ---TDKMLIISTVT--SRSIGYTTLLDFLSNNWDDIHHKFYNNTNIW------TKLISSATGMFS 876
               .|.:..:|.|:  .|.:.:    .:|...|:.|       .|.|      |:.||:....|:
plant   769 VRNQDALYGLSGVSWEGREVAW----KWLQEKWEYI-------GNTWGSGFLITRFISAVVSPFA 822

  Fly   877 TQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWID 928
            :.|....|::|:         |........|.:|:.|    :.:.:...|::
plant   823 SFEKAKEVEEFF---------ATRSKPSMARTLKQSI----ERVHINANWVE 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	111/482 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	72/350 (21%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	111/480 (23%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	75/367 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920