DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and Erap1

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	977	Identity:	230/977 - (23%)
Similarity:	407/977 - (41%)	Gaps:	174/977 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            :.:|||:.:.|:.|:::|..::....|.|...:.:.....:..:..|:|..      ||:..||.
Mouse    39 NNMRLPEYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHL------QISKATLR 97

  Fly   114 MGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGN 178
            .|.|.: .:...|:.:..|......|.....:..||...:.|.:..|:||:..|.::|.|..  .
Mouse    98 RGAGEM-LSEEPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRT--Q 159

  Fly   179 DGE-EIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL 242
            :|| .|..||..:|..||..|||||||.:|..|::.|.|...::.:.|.||..::|  .......
Mouse   160 EGEMRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVN--VAEGLIE 222

  Fly   243 DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVAHTTI- 306
            |.|..|..|||:...|:|              ||..:::..:.:....::..:.:|:|.|...:
Mouse   223 DHFDITVKMSTYLVAFII--------------SDFKSVSKMTKSGVKVSVYAVPDKINQADYALD 273

  Fly   307 ---------QHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIARESEIL---KKD----- 350
                     :.:||||.||.|.|:.|||.     |.|.:    |:...|||.:|   :|.
Mouse   274 AAVTLLEFYEDYFNIPYPLPKQDLAAIPD-----FQSGAMENWGLTTYRESSLLYDKEKSSASSK 333

  Fly   351 ---VFEISRELIYQWIGIWITPEWWTDANVNKALISFIASEIV---------------------- 390
               ...:|.||.:||.|..:|.|||.|..:|:....|:  |.|
Mouse   334 LGITMIVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFM--EFVSVTVTHPELKVEDYFFGKCFNA 396

  Fly   391 FEINGGIEFNGKYPMTILYSLYYELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKYTF 452
            .|::.   .|..:|::.            |..:...|:..|..:   |...|:.||...:...||
Mouse   397 MEVDA---LNSSHPVST------------PVENPAQIREMFDDVSYEKGACILNMLRDYLSADTF 446

  Fly   453 RLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSD-------------------LSILSIAE 498
            :.||..::..|.:|..|:.|.||::......|.:...|                   :.:.::..
Mouse   447 KRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMN 511

  Fly   499 SWLEHSRLPLVTIIRDYDSETAIVQQKVYLR--ERLHDVPDQDNMLWWIPIAL--KRQDSLSFVN 559
            :|......||:||  ........::|:.|::  ||.    .:...||.:|:..  .:.||:.
Mouse   512 TWTLQKGFPLITI--TVSGRNVHMKQEHYMKGSERF----PETGYLWHVPLTFITSKSDSVQ--- 567

  Fly   560 TGSFKWMNKTR-QMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYT 623
                :::.||: .:||  ||....:|..|....|.:.|:|.|:.|..||..|:  |...:|....
Mouse   568 ----RFLLKTKTDVLI--LPEAVQWIKFNVGMNGYYIVHYADDGWASLSGLLK--EAHTTISSND 624

  Fly   624 RAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQ---VGKRLEKS---SINK 682
            ||.|:::|:.|....:|:...||::||:||.|...:   |:|..|::   :.|.:||.   .:..
Mouse   625 RASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIM---PIFQALNELIPMYKLMEKRDMIEVET 686

  Fly   683 KFELYIIELLAPLYEYLGTAHFNEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSF 745
            :|:.::::||..|   :....:.::.:::|  ||.......|...|.||.:.|.|.|..|.:|
Mouse   687 QFKDFLLKLLKDL---IDKQTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYFREWKSS-- 746

  Fly   746 PNFETPVPNEYICSIFKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLE 810
             |....:|.:...::|..|:..  ..|.|.|....:|.:.|.....::.........:|:..||:
Mouse   747 -NGNMSIPIDVTLAVFAVGAQN--TEGWDFLYSKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLD 808

  Fly   811 LA----ILKNISIFSDTDKMLIISTVTSRS-IGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISS 870
            .:    |:|       |.:...|.|:..|: :||.....||..||:.:..||...::....::..
Mouse   809 QSFKGEIIK-------TQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHMVMG 866

  Fly   871 ATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYLSDAP 935
            .|..|||:...:.||.|:.. ....|.....:::::..|:|.|:|..:|...|..|:.   .:.|
Mouse   867 TTDQFSTRARLEEVKGFFSS-LKENGSQLRCVQQTIETIEENIRWMDKNFDKIRLWLQ---KEKP 927

  Fly   936 KL 937
            :|
Mouse   928 EL 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	117/512 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	81/334 (24%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	117/511 (23%)
		Substrate binding. /evidence=ECO:0000250	306..310		0/3 (0%)
		ERAP1_C	586..905	CDD:403137	81/339 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920