DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG40470 and ERAP2

DIOPT Version :9

Sequence 1:NP_001036635.1 Gene:CG40470 / 3355093 FlyBaseID:FBgn0058470 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001123612.1 Gene:ERAP2 / 64167 HGNCID:29499 Length:960 Species:Homo sapiens


Alignment Length:1014 Identity:227/1014 - (22%)
Similarity:436/1014 - (42%) Gaps:184/1014 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RTLFILTILL---------TAPGLEAFVNDFSSLHVIS--------EVRLPKEVLPLSYEVLIEP 68
            |..:.||.:|         :.|....|..|..:..|.:        |:|||..|:||.|::.:.|
Human    20 RGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHP 84

  Fly    69 HMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPR 133
            ::.:.:|..|.::.:.....::.:..|:.|   ::::  |.|..:..|....|....|:.:..|.
Human    85 NLTSLDFVASEKIEVLVSNATQFIILHSKD---LEIT--NATLQSEEDSRYMKPGKELKVLSYPA 144

  Fly   134 KPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLA-TNLKPNNARRL 197
            .....|.:.:|:....:..:.:.||..:.:..||.::|.|...|  ||...|| |:.:|..||..
Human   145 HEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLG--GETRILAVTDFEPTQARMA 207

  Fly   198 FPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL-DFFHTTAPMSTHAFGFVIL 261
            |||||||..|..|::.|.|...:|.|.|.|...||   :|....| |.|.||..|||:...:::.
Human   208 FPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI---ELEGGLLEDHFETTVKMSTYLVAYIVC 269

  Fly   262 KLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVAHTTIQ----------HFFNIPLPL 316
            ..|              :::.::::....::....:|.|..|..:|          .:|:|..||
Human   270 DFH--------------SLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPL 320

  Fly   317 TKLDVIAIPSLATLPFISAS-GILIARESEILKKDVFE---------------ISRELIYQWIGI 365
            :|||:||||..|  |....: |::..||:.:|    |:               |:.||.:||.|.
Human   321 SKLDLIAIPDFA--PGAMENWGLITYRETSLL----FDPKTSSASDKLWVTRVIAHELAHQWFGN 379

  Fly   366 WITPEWWTDANVNKALISFIASEIVFEINGGIEFNGKYPMTILYSLYY----------------- 413
            .:|.|||.|..:.:....::      |:   |..|..|| .:.:..|:                 
Human   380 LVTMEWWNDIWLKEGFAKYM------EL---IAVNATYP-ELQFDDYFLNVCFEVITKDSLNSSR 434

  Fly   414 ELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWN 475
            .:||  |....|.|:..|..:   |...|:.||...:|:..|:.||..::..:.::..|:.|.|:
Human   435 PISK--PAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWS 497

  Fly   476 AITTQAKADNSLDSDLS------------------------ILSIAESWLEHSRLPLVTIIRDYD 516
            ::     :::.|:||.:                        :..:..:|.....:||:.:.:|..
Human   498 SL-----SNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGC 557

  Fly   517 SETAIVQQKVYLRERLHDVPD----QDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNL 577
            |  ..:||:.:|:....:.|:    |:..||.||:......| :.::....|  :||..:   :|
Human   558 S--LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSS-NVIHRHILK--SKTDTL---DL 614

  Fly   578 PSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNF 642
            |.|..::..|.:..|.:.|:|:.:.|:.|...|  .:....:....|..|:||.:.|..||.|..
Human   615 PEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQL--NQNHTLLRPKDRVGLIHDVFQLVGAGRLTL 677

  Fly   643 STALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEK---SSINKKFELYIIELLAPLYEYLGTAHF 704
            ..||::|.:|::|.:........::|:.....:::   |.|::..:.|:::...|:   :....:
Human   678 DKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPV---IDRQSW 739

  Fly   705 NEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMK 767
            ::..::.:  ||.......|...:.||.::|...|:.|:.||   .:..:|.:.:..::..|:..
Human   740 SDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESS---GKLNIPTDVLKIVYSVGAQT 801

  Fly   768 E--WMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELA----ILKNISIFSDTDKM 826
            .  |.:.|:   ::..|...:::..:|..|:....| :|:..|:||.    ::|..::.:     
Human   802 TAGWNYLLE---QYELSMSSAEQNKILYALSTSKHQ-EKLLKLIELGMEGKVIKTQNLAA----- 857

  Fly   827 LIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYD-- 889
             ::..:..|..|.....||:..||..:..||...:.....:||..|..||:::....||.|::  
Human   858 -LLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESL 921

  Fly   890 EHYG-HFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            |..| |....|.::|...:|||    |.::|:|.:..|:
Human   922 EAQGSHLDIFQTVLETITKNIK----WLEKNLPTLRTWL 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG40470NP_001036635.1 GluZincin 60..503 CDD:301352 117/514 (23%)
ERAP1_C 584..906 CDD:288671 69/335 (21%)
ERAP2NP_001123612.1 Peptidase_M1 68..458 CDD:279741 107/431 (25%)
M1_APN_2 76..548 CDD:189008 117/518 (23%)
Substrate binding 334..338 0/3 (0%)
ERAP1_C 621..938 CDD:288671 69/334 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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