DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and ERAP2

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	1014	Identity:	227/1014 - (22%)
Similarity:	436/1014 - (42%)	Gaps:	184/1014 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RTLFILTILL---------TAPGLEAFVNDFSSLHVIS--------EVRLPKEVLPLSYEVLIEP 68
            |..:.||.:|         :.|....|..|..:..|.:        |:|||..|:||.|::.:.|
Human    20 RGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHP 84

  Fly    69 HMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPR 133
            ::.:.:|..|.::.:.....::.:..|:.|   ::::  |.|..:..|....|....|:.:..|.
Human    85 NLTSLDFVASEKIEVLVSNATQFIILHSKD---LEIT--NATLQSEEDSRYMKPGKELKVLSYPA 144

  Fly   134 KPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLA-TNLKPNNARRL 197
            .....|.:.:|:....:..:.:.||..:.:..||.::|.|...|  ||...|| |:.:|..||..
Human   145 HEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLG--GETRILAVTDFEPTQARMA 207

  Fly   198 FPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL-DFFHTTAPMSTHAFGFVIL 261
            |||||||..|..|::.|.|...:|.|.|.|...||   :|....| |.|.||..|||:...:::.
Human   208 FPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI---ELEGGLLEDHFETTVKMSTYLVAYIVC 269

  Fly   262 KLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVAHTTIQ----------HFFNIPLPL 316
            ..|              :::.::::....::....:|.|..|..:|          .:|:|..||
Human   270 DFH--------------SLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPL 320

  Fly   317 TKLDVIAIPSLATLPFISAS-GILIARESEILKKDVFE---------------ISRELIYQWIGI 365
            :|||:||||..|  |....: |::..||:.:|    |:               |:.||.:||.|.
Human   321 SKLDLIAIPDFA--PGAMENWGLITYRETSLL----FDPKTSSASDKLWVTRVIAHELAHQWFGN 379

  Fly   366 WITPEWWTDANVNKALISFIASEIVFEINGGIEFNGKYPMTILYSLYY----------------- 413
            .:|.|||.|..:.:....::      |:   |..|..|| .:.:..|:
Human   380 LVTMEWWNDIWLKEGFAKYM------EL---IAVNATYP-ELQFDDYFLNVCFEVITKDSLNSSR 434

  Fly   414 ELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWN 475
            .:||  |....|.|:..|..:   |...|:.||...:|:..|:.||..::..:.::..|:.|.|:
Human   435 PISK--PAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWS 497

  Fly   476 AITTQAKADNSLDSDLS------------------------ILSIAESWLEHSRLPLVTIIRDYD 516
            ::     :::.|:||.:                        :..:..:|.....:||:.:.:|..
Human   498 SL-----SNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGC 557

  Fly   517 SETAIVQQKVYLRERLHDVPD----QDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNL 577
            |  ..:||:.:|:....:.|:    |:..||.||:......| :.::....|  :||..:   :|
Human   558 S--LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSS-NVIHRHILK--SKTDTL---DL 614

  Fly   578 PSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNF 642
            |.|..::..|.:..|.:.|:|:.:.|:.|...|  .:....:....|..|:||.:.|..||.|..
Human   615 PEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQL--NQNHTLLRPKDRVGLIHDVFQLVGAGRLTL 677

  Fly   643 STALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEK---SSINKKFELYIIELLAPLYEYLGTAHF 704
            ..||::|.:|::|.:........::|:.....:::   |.|::..:.|:::...|:   :....:
Human   678 DKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPV---IDRQSW 739

  Fly   705 NEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMK 767
            ::..::.:  ||.......|...:.||.::|...|:.|:.||   .:..:|.:.:..::..|:..
Human   740 SDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESS---GKLNIPTDVLKIVYSVGAQT 801

  Fly   768 E--WMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELA----ILKNISIFSDTDKM 826
            .  |.:.|:   ::..|...:::..:|..|:....| :|:..|:||.    ::|..::.:
Human   802 TAGWNYLLE---QYELSMSSAEQNKILYALSTSKHQ-EKLLKLIELGMEGKVIKTQNLAA----- 857

  Fly   827 LIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYD-- 889
             ::..:..|..|.....||:..||..:..||...:.....:||..|..||:::....||.|::
Human   858 -LLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESL 921

  Fly   890 EHYG-HFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            |..| |....|.::|...:|||    |.::|:|.:..|:
Human   922 EAQGSHLDIFQTVLETITKNIK----WLEKNLPTLRTWL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	117/514 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	69/335 (21%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	107/431 (25%)
		M1_APN_2	76..548	CDD:189008	117/518 (23%)
		Substrate binding	334..338		0/3 (0%)
		ERAP1_C	621..938	CDD:288671	69/334 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920