DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and Enpep

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	933	Identity:	219/933 - (23%)
Similarity:	395/933 - (42%)	Gaps:	134/933 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGD 116
            |||..:.|:.|::.::..|:...:.|.:.:.:....|::.::.|..:|.:..:.::...:
  Rat    84 RLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRITKLPELRRPS----- 143

  Fly   117 GTLDKNVIILRGVRLPRKPVFVLYLKDKI---KKGSECLLDIYFQGNISETEEGLFRSYYTNSGN 178
               .:.|.|.|.....::...|:..::.:   ...|...|.|.|:|.::.:..|.:|:.||..|.
  Rat   144 ---GEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTEDGQ 205

  Fly   179 DGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPL--HNTINHPKLRSYS 241
              .:...||:.:|.:||:.|||||||..|..:|:|:..||.|..|.|.|:  ..|:::    .:.
  Rat   206 --TKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKEETLDN----DWK 264

  Fly   242 LDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVAHTTI 306
            ...|..:.||||:...|.:   |.:...:....|..|.......|...|    .:...|:.....
  Rat   265 KTTFMKSVPMSTYLVCFAV---HQFTSIQRTSRSGKPLTVYVQPNQKQT----AEYAANITKAVF 322

  Fly   307 QHF---FNIPLPLTKLDVIAIPSLATLPFISASGILIARESEILKKDVFE-----------ISRE 357
            ..|   |.:...|.|||.||||...| ..:...|::..||:.:|...:..           ::.|
  Rat   323 DFFEDYFAMEYSLPKLDKIAIPDFGT-GAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHE 386

  Fly   358 LIYQWIGIWITPEWWTDANVNKALISF--------------IASEIVFE----INGGIEFNGKYP 404
            |::||.|..:|.:||.|..:|:...||              :.|:::.|    :.........:|
  Rat   387 LVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHP 451

  Fly   405 MTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYK 469
            :.:..|...|::     |...||.:.    |...|:|||...:....|:.|.|.::.::|||..|
  Rat   452 VVVTVSTPAEIT-----SVFDGISYS----KGASILRMLQDWITPEKFQKGCQIYLENFKFKNAK 507

  Fly   470 SSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHD 534
            :||||:::   .||.|.     .:..:.::|......|:||:     |....|.||.:|.:...|
  Rat   508 TSDFWDSL---EKASNQ-----PVKEVMDTWTSQMGYPVVTV-----SGKQNVTQKRFLLDYKAD 559

  Fly   535 VPDQDNML---WWIPIALKRQDSLSFVNTGSFKW-------------MNKTRQMLISNLPSKNMF 583
            .....:.|   |.|||                ||             .|:....|.:|| |.:.|
  Rat   560 PSQPPSALGYTWNIPI----------------KWTENGNSNITVYYRSNREGITLNANL-SGDGF 607

  Fly   584 IIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNV 648
            :.:|.:.||.:.|||:...|:.:::.|.:.....|..  .|:..:.||:.||.|..|::..|||:
  Rat   608 LKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSSA--DRSSFIDDAFALARAQLLDYEKALNL 670

  Fly   649 TLFLKYERNHIVWSPVFTFLDQVGKRLEKS-SINKKFELYIIELLAPLYEYLGTAHFNEDINITE 712
            |.:|..|::.:.|..|.:.:..:....|.. .:....|.|....:.|:.:.||..  :...:||:
  Rat   671 TRYLTSEKDFLPWERVISAVSYIISMFEDDRELYPLIETYFRSQVKPIADSLGWQ--DTGSHITK 733

  Fly   713 -LRKLTTSFLCKAGYFPCFKEARRAFNIWI--NSSFP-NFETPVPNEYICSIFKWGSMKEWMFGL 773
             ||.....|.||.|.......|.:.|..|:  |.|.| |....|   |...:...|:...|.:.|
  Rat   734 LLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIPVNLRLLV---YRYGMQNSGNEAAWNYTL 795

  Fly   774 DRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRSIG 838
            :   ::.|:.:..::.   |:|.|..:.:|...:...|.:||:.:|....|...:|..::..|.|
  Rat   796 E---QYQKTSLAQEKE---KLLYGLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYG 854

  Fly   839 YTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIE 903
            .:...:::..|||.:.::|..|.....::::.|. .|:|:.....::.|:.: |.:.|......|
  Rat   855 KSMAWNWIQLNWDYLVNRFTINDRYLGRIVTIAE-PFNTELQLWQMQSFFAK-YPNAGAGAKPRE 917

  Fly   904 KSLRNIKEGIQWSKQNIPVIEEW 926
            :.|..:|..|:|.|.|...|.||
  Rat   918 QVLETVKNNIEWLKLNRKSISEW 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	109/479 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	75/326 (23%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	93/420 (22%)
		M1_APN_2	92..537	CDD:189008	109/483 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		0/3 (0%)
		ERAP1_C	608..922	CDD:288671	76/328 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020