DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40470 and RNPEPL1

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_060696.4	Gene:	RNPEPL1 / 57140	HGNCID:	10079	Length:	725	Species:	Homo sapiens

Alignment Length:	361	Identity:	75/361 - (20%)
Similarity:	130/361 - (36%)	Gaps:	92/361 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 RRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLD-----FFHTTAPMSTH 254
            |..|||||.|.:|..::..:..|.|...|.:.          .||..::     .||...|:..:
Human   203 RSFFPCFDTPAVKCTYSAVVKAPSGVQVLMSA----------TRSAYMEEEGVFHFHMEHPVPAY 257

  Fly   255 AFGFVILKLHMWNEHKIVKSSDI-PAINIWSNNL---SSTNLLD--IQNKLNVAHTTIQHFFNIP 313
            ....|...|         |.:|| |...:|:...   ::|:.|.  ::..|:.|    :..:. |
Human   258 LVALVAGDL---------KPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLSAA----ERLYG-P 308

  Fly   314 LPLTKLDVIAIPSLATLPFISASG-ILIARESEILKKD---VFEISRELIYQWIGIWITPEWWTD 374
            ....:.|::.:|  .:.|.::... .|....|.||:.|   |.::..|:.:.|.|..:|...|.:
Human   309 YMWGRYDIVFLP--PSFPIVAMENPCLTFIISSILESDEFLVIDVIHEVAHSWFGNAVTNATWEE 371

  Fly   375 ANVNKALISFIASEIVFEINGGIEFNGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQL- 438
            ..:::.|.::....|..|..|.       ..|.|.:. :.|...:....:.|.....:.::|:|
Human   372 MWLSEGLATYAQRRITTETYGA-------AFTCLETA-FRLDALHRQMKLLGEDSPVSKLQVKLE 428

  Fly   439 ----IIRMLSLTVGKYTFRLGIQSFICDYKFKTYKS---------SDFWNAIT-----TQAKADN 485
                ...:::|    :|:..|       |.|..|.|         .||..|..     |...|.:
Human   429 PGVNPSHLMNL----FTYEKG-------YCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQD 482

  Fly   486 SLDSDLSIL------SI-------AESWLEHSRLPL 508
            .|||.||..      |:       .|.||..:..||
Human   483 LLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	73/354 (21%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	72/353 (20%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	326..330		0/3 (0%)
		Leuk-A4-hydro_C	560..673	CDD:401171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..699
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810