DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40470 and erap1a

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	975	Identity:	226/975 - (23%)
Similarity:	418/975 - (42%)	Gaps:	174/975 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHA------------------ 96
            ::|||:.|.|..|::||.|::.:..|.|.:::.:....|::.:..|:
Zfish    41 KMRLPEIVKPQHYDLLIHPNLTSLTFTGEVQIQIEVKQDTRAIILHSKNLQVSKALLLGSRQHHH 105

  Fly    97 HDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNI 161
            |..|.|...:.|.......:|.                         ..:|||. ::.:.|..|:
Zfish   106 HQDLQISEFEANEQIALFSEGF-------------------------TFEKGSH-VVHLEFYANL 144

  Fly   162 SETEEGLFRSYYTNSGNDGEEIYLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFN 225
            |::..|.::..||.  |.||...|| |..:|.:||..|||||||..|..|.:.:.|...:|::.|
Zfish   145 SDSFHGFYKGQYTT--NSGEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRESRHISISN 207

  Fly   226 TPLHNTINHPKLRSYSL------DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWS 284
            .        ||||:..|      |.|.|...|||:...|:|...|..::    ||.....|::::
Zfish   208 M--------PKLRTVELADGILEDQFDTMVKMSTYLVAFIICDFHSISK----KSQHGVEISVYT 260

  Fly   285 NNLSSTNLLDIQNKLNVAHTTI---QHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIAR 342
               ....:...:..|:.|.|.:   ..:|:||.||.|.|:.|||.     |.|.:    |:...|
Zfish   261 ---VPEKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPD-----FQSGAMENWGLSTYR 317

  Fly   343 ESEIL----------KKDVFE-ISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGG 396
            ||.:|          |..:.: |:.||.:||.|..:|.:||.|..:|:....|:....|...:..
Zfish   318 ESGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPE 382

  Fly   397 IEFNGKYPMTILYSLYYE-LSKRYPNS-------HITGIKHEFASIKVQLIIRMLSLTVGKYTFR 453
            ::.|..:......:|..: ||..:|.|       .|:.:..:.:..|...|:.||...:....|:
Zfish   383 LQVNDYFLEKCFTALSVDSLSSSHPVSTPVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFK 447

  Fly   454 LGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDS-------------------------DLSI 493
            .||.:::..:.::...:|..|.::|....:| .|||                         .:.:
Zfish   448 YGIINYLKKHSYQNTVNSHLWESLTNICTSD-GLDSGRLKLDGFCSKHTAETPASKWFKEDSVDV 511

  Fly   494 LSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFV 558
            .:|.::|......||:|:  :...:...::|:.:|:..  :..:..:.||.:|        |:::
Zfish   512 GAIMDTWTLQEGFPLITV--EVKGQEVTLKQERFLKGA--ESSNSSSFLWQVP--------LTYI 564

  Fly   559 NTGSFKWMNKTRQMLISN------LPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRE 617
            .:||    |..::.|:..      ||.|..:|..|.:..|.:.|:|:...|:.|.|.||...
Zfish   565 TSGS----NAVQRFLLKTERDVFYLPEKVEWIKFNVDLRGYYIVHYESGGWDCLIKQLRMNH--- 622

  Fly   618 SIPVYT---RAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEK-- 677
              .|::   ||.|:||.:.|....::....|||::|:|..|...:..:..|:.|..:.|.:||
Zfish   623 --TVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVTQGFSELVPLYKLMEKRD 685

  Fly   678 -SSINKKFELYIIELLAPLYEYLGTAHFNEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNI 739
             ..:..:.:.::::|..||   :....::::.:::|  ||.....|.|...|..|...|.:.|:.
Zfish   686 MQELENQLKSHLVKLFQPL---IDRQSWSDNGSVSERMLRNYLLLFACVRRYPSCVSTATQLFHK 747

  Fly   740 WINSSFPNFETPVPNEYICSIFKWGSMKE--WMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQR 802
            |..|....:   :|.:....::..|:..:  |.|.|::   :.:|...|::..:...|:..|...
Zfish   748 WKESDGKMW---LPTDVSLVVYTEGARTDDGWDFLLEK---YKRSVSPSEKWMIKAALSYSPLAH 806

  Fly   803 DKIFILLELAILKNISIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKL 867
             |:..|||.:....|....|...|||  :|:....|:....|||.:||..:..||...::..:::
Zfish   807 -KLQWLLERSSEGEIMKTQDLPSMLI--SVSKNPKGFKLAWDFLKSNWGKLVKKFDLGSSAISRV 868

  Fly   868 ISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYLS 932
            :...|..:||:|..|.|:.|:.......|.....|:::|..|::.|.|..:|:|:::.|:||:.|
Zfish   869 VVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSIQQALEKIQQNILWMDRNVPLLKAWLDHHTS 933

Fly 933 932
Zfish 934 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	117/518 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	78/331 (24%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	106/434 (24%)
		M1_APN_2	52..525	CDD:189008	117/521 (22%)
		ERAP1_C	592..909	CDD:288671	79/333 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920