DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and ERAP1

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	972	Identity:	234/972 - (24%)
Similarity:	422/972 - (43%)	Gaps:	181/972 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            :::|||:.|:|:.|::||..::....|.|:.::.:.....:..:..|:|..      ||:..||.
Human    50 NKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHL------QISRATLR 108

  Fly   114 MGDG-TLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSG 177
            .|.| .|.:..  |:.:..||:....|...:.:..|....:.|::.||:|||..|.::|.|..
Human   109 KGAGERLSEEP--LQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRT-- 169

  Fly   178 NDGE-EIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYS 241
            .:|| .|..:|..:|..||..|||||||..|..|::.|.|...::.:.|.||        ::|.:
Human   170 KEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPL--------VKSVT 226

  Fly   242 L------DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLN 300
            :      |.|..|..|||:...|:|              ||..:::..:.:....::..:.:|:|
Human   227 VAEGLIEDHFDVTVKMSTYLVAFII--------------SDFESVSKITKSGVKVSVYAVPDKIN 277

  Fly   301 VAHTTI----------QHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIARESEIL---K 348
            .|...:          :.:|:||.||.|.|:.|||.     |.|.:    |:...|||.:|   :
Human   278 QADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPD-----FQSGAMENWGLTTYRESALLFDAE 337

  Fly   349 KD--------VFEISRELIYQWIGIWITPEWWTDANVNKA---LISFIASEIVF-EINGGIEFNG 401
            |.        ...::.||.:||.|..:|.|||.|..:|:.   .:.|::..:.. |:..|..|.|
Human   338 KSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFG 402

  Fly   402 K-------------YPMTILYSLYYELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKY 450
            |             :|::.            |..:...|:..|..:   |...|:.||...:...
Human   403 KCFDAMEVDALNSSHPVST------------PVENPAQIREMFDDVSYDKGACILNMLREYLSAD 455

  Fly   451 TFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSD-------------------LSILSI 496
            .|:.||..::..:.:|..|:.|.|:::.:....|.....|                   :.:.::
Human   456 AFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTM 520

  Fly   497 AESWLEHSRLPLVTI-IRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNT 560
            ..:|......||:|| :|   .....::|:.|::.. ...|| ...||.:|        |:|:.:
Human   521 MNTWTLQKGFPLITITVR---GRNVHMKQEHYMKGS-DGAPD-TGYLWHVP--------LTFITS 572

  Fly   561 GS---FKWMNKTR-QMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPV 621
            .|   .:::.||: .:||  ||.:..:|..|....|.:.|:|:|:.|:.|:..|:  ....::..
Human   573 KSDMVHRFLLKTKTDVLI--LPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLK--GTHTAVSS 633

  Fly   622 YTRAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQ---VGKRLEKSSINK- 682
            ..||.|:::|:.|...|:|:...||:::|:||:|...:   |||..|::   :.|.:||..:|:
Human   634 NDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIM---PVFQGLNELIPMYKLMEKRDMNEV 695

  Fly   683 --KFELYIIELLAPLYEYLGTAHFNEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINS 743
              :|:.::|.||..|   :....:.::.:::|  ||.......|...|.||.:.|...|..|..|
Human   696 ETQFKAFLIRLLRDL---IDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKES 757

  Fly   744 SFPNFETPVPNEYICSIFKWG--SMKEWMFGLDR----LCEFPKSRIQSDRTHLLKMLAGCPAQ- 801
               |....:|.:...::|..|  |.:.|.|...:    |....||:|:         .|.|..|
Human   758 ---NGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIE---------FALCRTQN 810

  Fly   802 RDKIFILLELAILKNISIFSDTDKMLIISTVTSRS-IGYTTLLDFLSNNWDDIHHKFYNNTNIWT 865
            ::|:..||:.: .|...|  .|.:...|.|:..|: :||.....||..||:.:..||...::...
Human   811 KEKLQWLLDES-FKGDKI--KTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIA 872

  Fly   866 KLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            .::...|..|||:...:.||.|:.. ....|.....:::::..|:|.|.|..:|...|..|:
Human   873 HMVMGTTNQFSTRTRLEEVKGFFSS-LKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	116/514 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	85/337 (25%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	116/518 (22%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	85/342 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920