Protein Alignment CG40470 and ERAP1

DIOPT Version :10

• Sequence 1: NP_001036635.1
• Gene: CG40470 / 3355093
• FlyBaseID: FBgn0058470
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_005272072.1
• Gene: ERAP1 / 51752
• HGNCID: 18173
• Length: 951
• Species: Homo sapiens
• Alignment Length: 972
• Identity: 234/972 - (24%)
• Similarity: 422/972 - (43%)
• Gaps: 181/972 - (18%)

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            :::|||:.|:|:.|::||..::....|.|:.::.:.....:..:..|:|..      ||:..||.
Human    50 NKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHL------QISRATLR 108

  Fly   114 MGDG-TLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSG 177
            .|.| .|.:..  |:.:..||:....|...:.:..|....:.|::.||:|||..|.::|.|..
Human   109 KGAGERLSEEP--LQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRT-- 169

  Fly   178 NDGE-EIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYS 241
            .:|| .|..:|..:|..||..|||||||..|..|::.|.|...::.:.|.||        ::|.:
Human   170 KEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPL--------VKSVT 226

  Fly   242 L------DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLN 300
            :      |.|..|..|||:...|:|              ||..:::..:.:....::..:.:|:|
Human   227 VAEGLIEDHFDVTVKMSTYLVAFII--------------SDFESVSKITKSGVKVSVYAVPDKIN 277

  Fly   301 VAHTTI----------QHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIARESEIL---K 348
            .|...:          :.:|:||.||.|.|:.|||.     |.|.:    |:...|||.:|   :
Human   278 QADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPD-----FQSGAMENWGLTTYRESALLFDAE 337

  Fly   349 KD--------VFEISRELIYQWIGIWITPEWWTDANVNKA---LISFIASEIVF-EINGGIEFNG 401
            |.        ...::.||.:||.|..:|.|||.|..:|:.   .:.|::..:.. |:..|..|.|
Human   338 KSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFG 402

  Fly   402 K-------------YPMTILYSLYYELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKY 450
            |             :|::.            |..:...|:..|..:   |...|:.||...:...
Human   403 KCFDAMEVDALNSSHPVST------------PVENPAQIREMFDDVSYDKGACILNMLREYLSAD 455

  Fly   451 TFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSD-------------------LSILSI 496
            .|:.||..::..:.:|..|:.|.|:::.:....|.....|                   :.:.::
Human   456 AFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTM 520

  Fly   497 AESWLEHSRLPLVTI-IRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNT 560
            ..:|......||:|| :|   .....::|:.|::.. ...|| ...||.:|        |:|:.:
Human   521 MNTWTLQKGFPLITITVR---GRNVHMKQEHYMKGS-DGAPD-TGYLWHVP--------LTFITS 572

  Fly   561 GS---FKWMNKTR-QMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPV 621
            .|   .:::.||: .:||  ||.:..:|..|....|.:.|:|:|:.|:.|:..|:  ....::..
Human   573 KSDMVHRFLLKTKTDVLI--LPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLK--GTHTAVSS 633

  Fly   622 YTRAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQ---VGKRLEKSSINK- 682
            ..||.|:::|:.|...|:|:...||:::|:||:|...:   |||..|::   :.|.:||..:|:
Human   634 NDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIM---PVFQGLNELIPMYKLMEKRDMNEV 695

  Fly   683 --KFELYIIELLAPLYEYLGTAHFNEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINS 743
              :|:.::|.||..|   :....:.::.:::|  ||.......|...|.||.:.|...|..|..|
Human   696 ETQFKAFLIRLLRDL---IDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKES 757

  Fly   744 SFPNFETPVPNEYICSIFKWG--SMKEWMFGLDR----LCEFPKSRIQSDRTHLLKMLAGCPAQ- 801
               |....:|.:...::|..|  |.:.|.|...:    |....||:|:         .|.|..|
Human   758 ---NGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIE---------FALCRTQN 810

  Fly   802 RDKIFILLELAILKNISIFSDTDKMLIISTVTSRS-IGYTTLLDFLSNNWDDIHHKFYNNTNIWT 865
            ::|:..||:.: .|...|  .|.:...|.|:..|: :||.....||..||:.:..||...::...
Human   811 KEKLQWLLDES-FKGDKI--KTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIA 872

  Fly   866 KLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            .::...|..|||:...:.||.|:.. ....|.....:::::..|:|.|.|..:|...|..|:
Human   873 HMVMGTTNQFSTRTRLEEVKGFFSS-LKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWL 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..502	CDD:472708	116/513 (23%)
		ERAP1_C	583..910	CDD:463368	85/342 (25%)
ERAP1	XP_005272072.1	M1_APN-Q_like	61..526	CDD:341064	116/513 (23%)
		ERAP1_C	597..916	CDD:463368	85/342 (25%)