DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40470 and enpep

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	964	Identity:	228/964 - (23%)
Similarity:	415/964 - (43%)	Gaps:	169/964 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            |..|||..:||..|::.:||.::...:.|.:.:||:....|:.::.|..||.:..:..:..::.:
Zfish    77 SNFRLPDYILPFHYDLHMEPDLNTDIYTGDVSVHLKLTQPSQHLWLHIRDTFVTVMPSLQRSSPS 141

  Fly   114 MGDGTLDKNVIILRGVRL-------PRKPVFVLYLKDKIKKGSE--CLLDIYFQGNISETEEGLF 169
            .           :..|:|       |::.|.|...:.....|.:  .:|.::|||.::.:..|.:
Zfish   142 G-----------VTSVKLKQCFEYKPQEYVVVEAAEQLSVTGPDEHYVLTLHFQGWLNGSLVGFY 195

  Fly   170 RSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNT--I 232
            |:.|..:|...:  ..||:.:|.:||:.|||||||..|..:.:||.....|..|.|.|:..|  :
Zfish   196 RTTYQENGVTKK--IAATDHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPVEKTEKL 258

  Fly   233 NHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQN 297
            :..|.::    .|..:..|||:...|.:   |.::..:......|| :.|::..|..:......:
Zfish   259 SEQKTKT----SFMKSVKMSTYLVCFAV---HQFDFVERTSKRGIP-LRIYAQPLQISTAAYAAD 315

  Fly   298 KLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISASGILIARESEIL----------KKDVF 352
            ...|.....:.:|::...:.|||.||||...| ..:...|::..||:.:|          |:.|.
Zfish   316 VTQVIFDYFEEYFDMEYSIQKLDKIAIPDFGT-GAMENWGLITYRETNLLFDEKESSSVNKQRVA 379

  Fly   353 E-ISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIE------------FNGKYP 404
            . |:.||::||.|..:|.:||.|..:|:...||      ||..|..|            .|..||
Zfish   380 SVIAHELVHQWFGNIVTMDWWDDLWLNEGFASF------FEYIGVEEAEHDWGMRDVMLINDVYP 438

  Fly   405 MTI---LYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLGIQSFICDYKFK 466
            :.:   |.|.:..:......:.||.:....:..|...|:|||...:|:.|||.|.:.::..|.|:
Zfish   439 VMVDDALLSSHPIIVDVSSPAEITSVFDAISYNKGASILRMLEDLLGRETFRDGCRRYLKTYLFQ 503

  Fly   467 TYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRER 531
            ..|:||||.|:     ||   :|.|.:..|.::|.:....|::: :.:.|:|..:.|.:..|.
Zfish   504 NAKTSDFWKAL-----AD---ESGLPVADIMDTWTKQMGYPVLS-LTNTDTEAKLTQTRFLLD-- 557

  Fly   532 LHDVPDQD--------NMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLP-SKNMFIIVN 587
                |:.|        ...|.||:..|..||    ...||.:.....:.:||... :.|..|.||
Zfish   558 ----PNADPSQPTTPLGYKWTIPVKWKALDS----TNNSFIFEKGQTEAVISGYSHATNGLIKVN 614

  Fly   588 EEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVY---TRAKLLHDAWNLAYAGELNFSTALNVT 649
            ::.:|.:.||:.|..|:.:::.|..:.:     ||   .|:..:.|.:.|..|..:::..|.|:|
Zfish   615 KDHMGFYRVNHHDQMWSDIAEQLLMDHQ-----VYDATDRSSYIDDIFALGRADMVDYGNAFNLT 674

  Fly   650 LFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLGTAH---------FN 705
            .:|..|..:|||..|...:..|.:.|...::           |.||::.|...|         :.
Zfish   675 RYLADETEYIVWDRVSASISYVREMLADDTV-----------LYPLFQKLFRGHVQKISRELGWK 728

  Fly   706 EDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSM-- 766
            ::.|.|:  ||::.....|:.|......:|...||.||..:..:    ||......::::|.|
Zfish   729 DEGNQTQRLLREIVLGIACQMGDQEALDQASDIFNKWIKGTIGS----VPVNLRLLVYRYGMMNS 789

  Fly   767 ---KEW--MFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNI--------- 817
               :.|  ||                :.:|...||   .::||  :|..||.:|||
Zfish   790 GTEESWEIMF----------------QKYLSATLA---QEKDK--LLYGLASVKNIHLLHRLLEA 833

  Fly   818 ----SIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQ 878
                ||....|...::..|:..|.|.....|:::.|||.:.:::..|.....:|.:..|..:|:.
Zfish   834 TKNESIIRSQDVFTLVQYVSRSSDGKIMAWDWMTLNWDYLVNRYTINDRNLGRLPARITTTYSSN 898

  Fly   879 EGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYLS 932
            .....::.|:..| .:.|..:...:::|..:|..|:|.::|...|..|:::.:|
Zfish   899 LQLWKMEHFFALH-PNAGAGEMPRKQALETVKNNIEWVERNKDEIRFWLENNVS 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	119/479 (25%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	77/355 (22%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	100/420 (24%)
		M1_APN_2	89..536	CDD:189008	119/482 (25%)
		ERAP1_C	611..927	CDD:288671	78/357 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020