DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	210/914 - (22%)
Similarity:	386/914 - (42%)	Gaps:	169/914 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VRLPKEVLPLSYEVLIEPHMDNQN-------FEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQIN 108
            :|||..::||.|::.:.|.:...|       |.|.:.:.:|....:..:..|   :..::..|:.
  Rat    93 LRLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLLLH---SFFLNYKQVE 154

  Fly   109 L------TTLNMGDGTLDKNVIILRGVRLPRKPVF--------VLYLKDKIKKGSECLLDIYFQG 159
            :      .|.|...|            |:|.:.|:        ||.|...:..||...|:..|.|
  Rat   155 VWGPLAPDTRNATVG------------RVPLENVWFALDMQYVVLDLGQSLDPGSSYELNFDFSG 207

  Fly   160 NI-SETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITL 223
            .: .|..||||.:.||:  .|.....:||.::|..||.:|||||||.:|..||::|....||:.|
  Rat   208 QVLQEGSEGLFLNLYTD--EDQLRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVAL 270

  Fly   224 FNTP----LHN-TINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIW 283
            .|.|    .|. .:|..:   :::..||||..|.|:....||.....     :.::.....|.:|
  Rat   271 SNMPQLGQSHRIDVNGSR---WTVTSFHTTPRMPTYLVALVICDFDY-----VSRTERGKEIRVW 327

  Fly   284 S--NNLSSTNLLDIQNKLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIAR 342
            :  ::::...|....|......:.::..|||..||.|.|:||:|:     |::.:    |::|..
  Rat   328 ARKDDIADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPT-----FVNGAMENWGLMIFD 387

  Fly   343 ESEILKKD----------VFEISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGI 397
            .|.:|:.|          :..:|.|:.:||.|..:|..||.:..:|:...|:      ||:....
  Rat   388 ASLLLELDDDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASY------FEVGLTN 446

  Fly   398 EFNGKYP------MTILYSLY---YELSKRYPNSHITGIKHE---------FASIKVQLIIRMLS 444
            .|..|.|      :|:|:.:.   :.|..|..::.:......         :...|...:..||:
  Rat   447 YFYPKVPRNMIFFLTVLHDILEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMAWMLA 511

  Fly   445 LTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLV 509
            ..:.::.|...::|::..:.:...:..|.|..|.......:.:....::..|.:||...|..|::
  Rat   512 GFLSQHLFINALKSYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVI 576

  Fly   510 TIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQ--- 571
            |:    ::.|.:|:|:.:..||:.:.....:..|.:||...:...     |....|::|:..
  Rat   577 TL----NASTGVVKQEPFYLERVENQTLLSHNTWIVPIFWMKNGI-----TQPLVWLDKSSMIFP 632

  Fly   572 -MLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLA 635
             |.:|:  |.:.::|:|....|.:.||||...|..|::.|..:.|  :|||..|.:|:.||:.|:
  Rat   633 GMKLSD--SDSDWVILNFNVTGYYRVNYDKLGWKKLNQQLEKDPK--AIPVINRLQLVSDAFALS 693

  Fly   636 YAGELNFSTALNVTLFLKYERNHIVWSPVFT--------------FLDQVGKRLEKSSINKKFEL 686
            ....:...|||::|.::..|...:||..|..              :|..:.|:.....:|..:.:
  Rat   694 KNNYIEIETALDLTKYIAKEDEILVWFEVLVNLINREVVYDVKNYYLYPLLKKYFLKRLNSIWTI 758

  Fly   687 Y---IIELLAPLYEYLGTAHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNF 748
            |   |.|.:|.|.:..        :::..|:|...: .|..|...|.:.:|..|..|:  :.|
  Rat   759 YSAIIRENMASLQDNF--------LSLLPLKKFFET-ACWLGLEDCLQLSRELFRKWM--AHP-- 810

  Fly   749 ETPVPNE----YICSIFKWGSMKEW--MFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFI 807
            ||.:|.:    .:|:....||.|:|  :|.|    ...|:..|.|..||:..: ||......:..
  Rat   811 ETAIPPQIEKVVLCNAIALGSNKDWDFLFNL----YINKTEEQEDLFHLVHAM-GCSKDPRTLNR 870

  Fly   808 LLELAILKNISIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIH---------HKFYNNTNI 863
            .:|..|....|.|::|:   :|..|....:|.....|||.|||..::         .:::  .::
  Rat   871 FMEYDITVFPSRFNETN---LIEVVAESEVGRYVAKDFLINNWVAVYESPSLSPLLQQYF--VSV 930

  Fly   864 WTKL 867
            ||.:
  Rat   931 WTTI 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	112/503 (22%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	77/316 (24%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	112/502 (22%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	75/294 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020