DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and CG14516

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	1027	Identity:	265/1027 - (25%)
Similarity:	462/1027 - (44%)	Gaps:	179/1027 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSAIYNFFIYICSSMASGTRTLFILTILLTAPGLEAFVND---FSSLHV-------------IS 49
            :.:||.....:||:.:|.|    ||:....|...||...::   .:|.|:             ..
  Fly    50 LTTAILLASFFICTLLAVG----FIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDR 110

  Fly    50 EVRLPKEVLPLSYEVLIEPHMD-NQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            :||||..:.||.|.:.|||.:. |..|.||:::.:|.:.|...:..||.:   :::|:.:.:...
  Fly   111 DVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEE---LNISRSDASVHR 172

  Fly   114 M-------GDG-TLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFR 170
            :       ||| .:.|..::      ..|..||:.|.||:.|..|.::.:.|.|.|.:..:|.:|
  Fly   173 VQNNGEPEGDGLRIHKQYLV------GAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYR 231

  Fly   171 SYYTNSGNDGEEIY------LATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLH 229
            |.|        |::      .:|..:..:|||.|||||||.:|..|.:.||||:...|:.|.|:.
  Fly   232 SSY--------EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIV 288

  Fly   230 NTINHPKLRSYSLDFFHTTAPMSTHAFGFVIL--------KLHMWNEHKIVKSSDIPAINIWSNN 286
            ::.:|..:.||..|.|..:.||||:...:.|.        ...:|.....:||::. |:::....
  Fly   289 SSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGNFAVWARADAIKSAEY-ALSVGPRI 352

  Fly   287 LSSTNLLDIQNKLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIARESEIL 347
            |                |.:|.|||:..||.|:|:||:|.     |.:.:    |::..||:.:|
  Fly   353 L----------------TFLQDFFNVTFPLPKIDMIALPE-----FQAGAMENWGLITFRETAML 396

  Fly   348 ----------KKDVFE-ISRELIYQWIGIWITPEWWTDANVN-------------------KALI 382
                      |:.|.. :..||.:||.|..:||.||:|..:|                   |.|.
  Fly   397 YDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLD 461

  Fly   383 SFIASEI--VFEINGGIEFNGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSL 445
            .|:.:|:  ||:::.         ::..:.:.:|:   :....|:.|....:..|...||||::.
  Fly   462 QFVVNELQAVFQLDA---------LSTSHKISHEV---FNPQEISEIFDRISYAKGSTIIRMMAH 514

  Fly   446 TVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVT 510
            .:....||.|:..::.:..:.:....|.|:.:|.:||:...||...|:..|.::|...:..|:|.
  Fly   515 FLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVK 579

  Fly   511 IIRDYDSETAIVQQK--VYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQML 573
            :.|..:|:...::|.  ||......|    :::||:|||.......|:|.||....||.:|:...
  Fly   580 VSRHPNSDVIRLEQVRFVYTNTTRED----ESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYE 640

  Fly   574 ISNLP-SKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYA 637
            :.|.. |...:.|.|.::.|.:.||||..||..::::|...:..|.|....||:|:.|..|||..
  Fly   641 LENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARG 705

  Fly   638 GELNFSTALNVTLFLKYERNHIVWSPV---FTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYL 699
            ..|::.||:|:|.:|.:|..|:.|...   |.|:|.:   ...|......:.|:::.|..:|:.:
  Fly   706 SYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSM---FVNSGDYDLLKNYLLKQLKKVYDQV 767

  Fly   700 G---TAHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETP-VPN---EYI 757
            |   :...:|||.:...|....|..|..|:..|..||.|.|..|:.:..|:...| |||   ...
  Fly   768 GFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVY 832

  Fly   758 CSIFKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAI----LKNIS 818
            ||..::|:..||.|..:|   |.|:.:..::..||..| ||..:...::..|...|    ::...
  Fly   833 CSAIQYGTEYEWDFAFER---FLKTNVPGEKDLLLNAL-GCSKEPWLLYRFLRRGISGQHIRKQD 893

  Fly   819 IFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWT--KLISSATGMFSTQ--- 878
            :|.      :.:.|::..:|.....|||.|||.:|  |.|..:.:.:  .|...||..|:::
  Fly   894 LFR------VFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQL 950

  Fly   879 -EGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDH 929
             |..:.||   |.|:.:....|.|:|    :|:..:.|..:|...|..|:::
  Fly   951 GEFENFVK---DAHWDYDRPVQQIVE----HIETSVDWMNKNYKSIVRWLEN 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	126/501 (25%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	94/341 (28%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	112/442 (25%)
		M1_APN_2	121..576	CDD:189008	126/505 (25%)
		ERAP1_C	652..974	CDD:288671	94/343 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920