DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40470 and npepps

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	946	Identity:	230/946 - (24%)
Similarity:	405/946 - (42%)	Gaps:	158/946 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVS-------QIN 108
            ||||.:|.|::|.:.::|.:.:..|||.:...:.....:.::..:..|..:|..|       :||
Zfish     8 VRLPTDVYPVNYGLRLKPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDIITASFVPDGGEEIN 72

  Fly   109 LTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYY 173
            .|..|..:.  |:.|              .|.....::|||.. |.|.|.|.:::..:|.:||.|
Zfish    73 ATGFNYQNE--DEKV--------------TLCFPSTLQKGSGS-LKIDFVGELNDKMKGFYRSKY 120

  Fly   174 TNSGNDGEEIYLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKL 237
            ::|   ||..|.| |..:..:|||.|||:|||.||..|::::..||..:.|.|.   |.::.
Zfish   121 SSS---GEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNM---NVVDR--- 176

  Fly   238 RSYSLD------FFHTTAPMSTHAFGFVILKLHMWNEHKIV--KSSDIPAINIWSNNLSSTNLLD 294
            :.|:.|      .|.||..|||:...|||      .|:..|  :|||...:.:::....:.
Zfish   177 KPYAEDQSLVEVKFATTPIMSTYLVAFVI------GEYDFVESQSSDGVTVRVYTPVGKAE---- 231

  Fly   295 IQNK--LNVAHTTI---QHFFNIPLPLTKLDVIAIPSLATLPFISASGILIARESEIL--KKDVF 352
             |.|  |.||..|:   :.:|::|.||.|:|:|||...|. ..:...|::..||:.:|  .|:..
Zfish   232 -QGKFALEVATKTLPFYKDYFSVPYPLPKIDLIAIADFAA-GAMENWGLVTYRETALLIDPKNSC 294

  Fly   353 EISR---------ELIYQWIGIWITPEWWTDANVNKALISFI----ASEIVFEINGGIEF----- 399
            ..||         ||.:||.|..:|.||||...:|:...|:|    ......|.:...:|
Zfish   295 ASSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADY 359

  Fly   400 ---------NGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLG 455
                     :..:|:        |:...:| |.:..|....:..|...:||||...:|...||.|
Zfish   360 TRALDLDALDNSHPI--------EVDVGHP-SEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKG 415

  Fly   456 IQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETA 520
            :.:::..::.|...:.|.|..: .||       |...|.::..||.:....|::.:.::......
Zfish   416 MNAYLLKFQHKNASTEDLWECL-EQA-------SGKPIAAVMNSWTKQMGFPIIVVDQEQHGSDR 472

  Fly   521 I--VQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQML--------IS 575
            :  :.||.:......:  |:|...|.:||::...:..|         ..||:.:|        |:
Zfish   473 VLKISQKKFCASGPRN--DEDCPNWMVPISICTSEDPS---------CTKTKILLDQPETTVNIT 526

  Fly   576 NLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGEL 640
            |: :.:.:|.:|...:|.:.:.|..   .||...|........:|| .|..|.:|.::||.||.:
Zfish   527 NV-APDHWIKINPGTVGFYRIQYSS---AMLESLLPGIRDLTLLPV-DRLGLQNDLFSLARAGMI 586

  Fly   641 NFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLG----T 701
            :....|.|......|.|:.|||.:...|..:...|..:..::..:.:|.:|..|:...||    |
Zfish   587 STVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLLSHTDFHEDIQEFIRDLFTPIGMKLGWDSRT 651

  Fly   702 AHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSS---FPNFETPVPNEYICSIFKW 763
            ...:.|   ..||.|....|.|||:....:||||.|...:...   ..:..:||   |: ::.|.
Zfish   652 GEGHLD---ALLRGLVLGKLGKAGHKATLEEARRRFREHVEGKQILSADLRSPV---YL-TVLKH 709

  Fly   764 GSMKEWMFGLDRLCEFPK-SRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKML 827
            |....    ||.:.:..| :.:|.::..:.::|...||. |.|..:|..|:.:.:   ...|.:.
Zfish   710 GDSTT----LDTMLKLHKQADMQEEKNRIERVLGAIPAP-DLIQRVLNFALSEEV---RPQDTVS 766

  Fly   828 IISTVT-SRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEH 891
            :|..|. |...|......|:.:||:::|:: |....:.::||......|:..:....||.|::.|
Zfish   767 VIGGVAGSSKQGRKAAWKFVKDNWEELHNR-YQGGFLISRLIKLTVDGFAIDKMAAEVKSFFESH 830

  Fly   892 YGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
              |...|:..:::...||.....|.|::...|.:::
Zfish   831 --HAPAAERTVQQCCENILLNAAWLKRDADDIHQYL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	126/492 (26%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	79/330 (24%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	113/433 (26%)
		M1_APN_2	17..459	CDD:189008	126/496 (25%)
		ERAP1_C	534..845	CDD:288671	79/332 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820