DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and LTA4H

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	672	Identity:	129/672 - (19%)
Similarity:	243/672 - (36%)	Gaps:	160/672 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 MHLRWIGDSKKVYFHAHDTLLIDVSQINLTT--LNMGDGTLDKNVIILRGVRLP-------RKPV 136
            :|||...|..:........|.:...:.||.:  |:..|.|::|.||..:.|:..       :...
Human    22 LHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSP 86

  Fly   137 FVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEE-IYLATNLKPNNARRLFPC 200
            ..:.|...:.|..|.:::|.|:  .|.....|  .:.|.....|:| .||.:..:..:.|.:.||
Human    87 MEISLPIALSKNQEIVIEISFE--TSPKSSAL--QWLTPEQTSGKEHPYLFSQCQAIHCRAILPC 147

  Fly   201 FDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLH- 264
            .|.|.:|:.:...::.||..:.|.:.........|:..|..:..|....|:..:....|:..|.
Human   148 QDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALES 212

  Fly   265 --------MWNEHKIVKSSDIPAINIWSNNLSST-NLLDIQNKLNVAHTTIQHFFNIPLPLTKLD 320
                    :|:|.:.|:.|        :...|.| ::|.|...|...:...|:           |
Human   213 RQIGPRTLVWSEKEQVEKS--------AYEFSETESMLKIAEDLGGPYVWGQY-----------D 258

  Fly   321 VIAIP--------SLATLPFISASGILIARESEILKKDVFEISRELIYQWIGIWITPEWWTDANV 377
            ::.:|        ....|.|::.:  |:|.:..:..    .|:.|:.:.|.|..:|.:.|....:
Human   259 LLVLPPSFPYGGMENPCLTFVTPT--LLAGDKSLSN----VIAHEISHSWTGNLVTNKTWDHFWL 317

  Fly   378 NKALISFIASEIV----------FEINGG--------IEFNGKYPMTILYSLYYELSKRYPNSHI 424
            |:....::...|.          |...||        ..|...:|.|   .|..:|:...|:...
Human   318 NEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFT---KLVVDLTDIDPDVAY 379

  Fly   425 TGIKHE--FASIKVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITT--QAKAD- 484
            :.:.:|  ||     |:..:..|..|...|...:::::..:.:|:..:.|:.:.:.:  :.|.|
Human   380 SSVPYEKGFA-----LLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDV 439

  Fly   485 -NSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIA 548
             |.:|.:        :||....||  .|..:||  ..:....:.|.:|            ||
Human   440 LNQVDWN--------AWLYSPGLP--PIKPNYD--MTLTNACIALSQR------------WI--- 477

  Fly   549 LKRQDSLSFVNTGSFK-----WMNKTRQMLISNLP-----SKNMFIIVNEEEIGPFPVNYDDNNW 603
            ..::|.|:..|....|     .:|:.....:...|     .|.|..:.|...|         ||.
Human   478 TAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAI---------NNS 533

  Fly   604 NMLSKYLR---TEEKRESIPVYTRAKLLHDAWNLA-YAGELNFSTAL--NVTLFLK--------Y 654
            .:..::||   ..:..::||:         |..:| ..|.:.|:..|  ::..|.|        |
Human   534 EIRFRWLRLCIQSKWEDAIPL---------ALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTY 589

  Fly   655 ERNHIVWSPVFTFLDQVGKRLE 676
            :.:.....||...|  |||.|:
Human   590 QEHKASMHPVTAML--VGKDLK 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	89/473 (19%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	23/107 (21%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	128/669 (19%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		0/4 (0%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		2/5 (40%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810