DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and LNPEP

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	959	Identity:	222/959 - (23%)
Similarity:	405/959 - (42%)	Gaps:	177/959 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHA--HDTLLIDVSQINLTT 111
            :::|||..|:||.||:.:.|::.:..|.||:.:.::.:..:..:..|:  |:        |:..|
Human   164 AQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHN--------ISRVT 220

  Fly   112 LNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNS 176
            ......:.:|...||   .........:...:.:..|....|.|.:..|||.:..|.:...||:.
Human   221 FMSAVSSQEKQAEIL---EYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE 282

  Fly   177 GNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYS 241
            .|: ::.:.||..:|..||..|||||||..|..|.:.|.|.:.|..|.|.        ||..|..
Human   283 SNE-KKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNM--------PKKSSVV 338

  Fly   242 L------DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLN 300
            |      |.|..:..|||:...|::      .|.|.: |.|:        |.:..::..:..|:.
Human   339 LDDGLVQDEFSESVKMSTYLVAFIV------GEMKNL-SQDV--------NGTLVSIYAVPEKIG 388

  Fly   301 VAH----TTI------QHFFNIPLPLTKLDVIAIPSLATLPFISAS----GILIARESEIL---- 347
            ..|    ||:      |::|.|..||.|||::|||.     |.:.:    |:|..||..:|
Human   389 QVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPD-----FEAGAMENWGLLTFREETLLYDSN 448

  Fly   348 ------KKDVFE-ISRELIYQWIGIWITPEWWTDANVNKALISFI---ASEIVF-EINGGIEF-- 399
                  :|.|.: |:.||.:||.|..:|.:||.|..:|:...:|:   :.|.:| |::...:|
Human   449 TSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLD 513

  Fly   400 -----------NGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFR 453
                       |..:|::         |....:..|..:....:..|...::.||...:.:..|:
Human   514 ARFKTMKKDSLNSSHPIS---------SSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQ 569

  Fly   454 LGIQSFICDYKFKTYKSSDFW---NAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDY 515
            ..:..::.::.:.:.:|.|.|   |.:|.|.         |.:..:.::|......|||| ::..
Human   570 HAVVLYLHNHSYASIQSDDLWDSFNEVTNQT---------LDVKRMMKTWTLQKGFPLVT-VQKK 624

  Fly   516 DSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLPSK 580
            ..|..|.|::.:|..:....|...:.||.||        ||:|..|    .|.::...:|.|..|
Human   625 GKELFIQQERFFLNMKPEIQPSDTSYLWHIP--------LSYVTEG----RNYSKYQSVSLLDKK 677

  Fly   581 NMFIIVNEEEI---------GPFPVNYDDNNWNMLSKYLRTEEKRESIPVYT-----RAKLLHDA 631
            :..|.:.||.:         |.:.|:|.|::|..|...|:       |..|.     ||.|:::.
Human   678 SGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLK-------INPYVLSDKDRANLINNI 735

  Fly   632 WNLAYAGELNFSTALNVTLFLKYERNHIVWSP----------VFTFLDQVG-KRLEKSSINKKFE 685
            :.||..|::....|.::..:|..| ||.  :|          ::..|:::| ..|....:.:.|:
Human   736 FELAGLGKVPLKRAFDLINYLGNE-NHT--APITEALFQTDLIYNLLEKLGYMDLASRLVTRVFK 797

  Fly   686 LYIIELLAPLYEYLGTAHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFET 750
            |...::....:...||.      ::.|||.....|.|......|...|.:.|:.|:.|   |...
Human   798 LLQNQIQQQTWTDEGTP------SMRELRSALLEFACTHNLGNCSTTAMKLFDDWMAS---NGTQ 853

  Fly   751 PVPNEYICSIFKWGSM--KEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAI 813
            .:|.:.:.::||.|:.  |.|.|.|.:......   ::::..:|:.||.....| |::.|::.::
Human   854 SLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGS---EAEKNKILEALASSEDVR-KLYWLMKSSL 914

  Fly   814 LKNISIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQ 878
              |...|.......||.||.....|:....||:..||:.:..||...:.....:::.:|.:|||:
Human   915 --NGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 977

  Fly   879 EGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            .....|:.|::.......|.: .::::|..|:..|||.::|:..:..|:
Human   978 THLSEVQAFFENQSEATFRLR-CVQEALEVIQLNIQWMEKNLKSLTWWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	113/495 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	76/348 (22%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101
		M1_APN_2	175..617	CDD:189008	113/499 (23%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	689..1009	CDD:314669	75/345 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920