DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and erap1b

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	1022	Identity:	242/1022 - (23%)
Similarity:	444/1022 - (43%)	Gaps:	175/1022 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MASGTRTLFILTILLTAPGLEAFVNDFSSLHVIS---------EVRLPKEVLPLSYEVLIEPHMD 71
            ||:.||...:|.:::....|.|.|....:...||         ::|||..:.||.|.:||.|::.
Zfish     1 MATMTRLPVLLNLIVLPIHLWAAVTPEPTSFPISSSGEPFPWNKMRLPDTISPLHYNLLIHPNLT 65

  Fly    72 NQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPV 136
            :.:|.||:::.:..:.|:|.:..|:.:   :.:|...|         ||.|:...:.:::...|.
Zfish    66 SLDFTGSVQIQIEVLQDTKTIILHSKN---LQISSARL---------LDANIAQQQPLKVLEYPY 118

  Fly   137 F--VLYLKDK--IKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRL 197
            |  :..:.||  :|:|....::::|..|:||:..|.::|.|..|..| ..:..:|..:..:||..
Zfish   119 FQQIALVSDKALLKRGHVYSVELHFAANLSESFHGFYKSTYRTSKGD-VRVVASTQFEATSARAA 182

  Fly   198 FPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL------DFFHTTAPMSTHAF 256
            |||||||..|..|:|.|.|...:|.|.|.        ||||:..|      |.|..:..|||:..
Zfish   183 FPCFDEPAFKANFSVQIRREAKHIALSNM--------PKLRTLELKNGLFEDQFDVSVKMSTYLV 239

  Fly   257 GFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVAHTTI----------QHFFN 311
            .:::              ||..:|:..|.:....::..:..|::.|...:          ..:|:
Zfish   240 AYIV--------------SDFLSISKTSQHGVQISVYAVPEKIDQAEFALDAAVKLLDFYDDYFD 290

  Fly   312 IPLPLTKLD--------------VIAIPSLATLP-FISAS----GILIARESEIL----KKDVFE 353
            ||.||.|.:              :|....||.:| |.|.:    |:...|||.:|    |....:
Zfish   291 IPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLFDPHKSSASD 355

  Fly   354 -------ISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIE----FNGKYPMTI 407
                   |:.||.:||.|..:|.:||.|..:|:....|:....|...|..::    |.||
Zfish   356 KLGITMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQVEDYFLGK----- 415

  Fly   408 LYSLYYE------LSKRYPNS----HITGIKHEFASI---KVQLIIRMLSLTVGKYTFRLGIQSF 459
                .:|      ||..:|.|    :...|:..|..:   |...|:.||...:....|:|||..:
Zfish   416 ----CFEAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKY 476

  Fly   460 ICDYKFKTYKSSDFWNAITT----------QAKADNSL--------------DSDLSILSIAESW 500
            :..|.::...:|:.|.::|.          :.|.|.|.              :.:|.:.::.|:|
Zfish   477 LKHYSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMMETW 541

  Fly   501 LEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKW 565
            ......||:||.  .......:.|:.||:.  .|:....:.||.:|:.....||     |...::
Zfish   542 TLQEGFPLITIA--VKGREVRLSQERYLKS--DDLSQTSSFLWQVPLTYITSDS-----TTVHRF 597

  Fly   566 MNKTRQMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHD 630
            :.||:..:: .||.:..:|..|.:..|.:.|:|:.:.|:.|...|:  ....::....||.|:::
Zfish   598 LLKTKTDVL-YLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLK--HNHTALSSNDRASLINN 659

  Fly   631 AWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKS---SINKKFELYIIELL 692
            |:.|...|:|....||::||:|..|...:..:..|..|..:.|.:||.   .:..:.:.||::|.
Zfish   660 AFQLVSVGKLPLDKALDLTLYLSKETEIMPVTQGFNELVPLYKLMEKRDMVELENQMKGYILQLF 724

  Fly   693 APLYEYLGTAHFNEDINITE--LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNE 755
            ..|.|   ...:.::.:::|  ||.....|.|..|:.||...|.:.||:|.:|   :....:||:
Zfish   725 QKLIE---QQLWTDEGSVSERMLRSYLLLFGCVRGHPPCVSNATQLFNLWRDS---DGNMSLPND 783

  Fly   756 YICSIFKWGSMKE--WMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNIS 818
            ...::|..|:..|  |.|..::   :.:|...|.::.:.:.|...|... |:..::|.::  ...
Zfish   784 VTMAVFSVGARTEDGWDFLFEK---YKESMYVSMKSRIKQALMTSPLDH-KLKWMMEQSL--EGE 842

  Fly   819 IFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDL 883
            :....|...::::|:.....|....|||..|||.:..||...::....::...|..:||:|....
Zfish   843 LIKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSIAHMVVGVTNQYSTREMLAE 907

  Fly   884 VKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHY 930
            |:.|:.......|.....|::::.||:|.|:|..:|:|:::.|:..|
Zfish   908 VRNFFSLLQPETGAELRCIQQAVENIEENIRWMDKNLPLLKAWLHRY 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	125/533 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	76/328 (23%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	111/450 (25%)
		M1_APN_2	54..548	CDD:189008	125/537 (23%)
		ERAP1_C	615..932	CDD:288671	76/330 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920