DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and CG3502

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	234/965 - (24%)
Similarity:	401/965 - (41%)	Gaps:	129/965 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHMD--NQNFEGSIRMHLRWIGDSKK 91
            |:..|.:.|...|:         |||:.|.||.|.:.|..|::  :|.||||:.:.|.....:|.
  Fly    15 LILVPSIRAVYEDY---------RLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKN 70

  Fly    92 VYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYL-----KDKIKKGSEC 151
            :..|| ..|.||.   |.|::..|......|.|.:..|.    ..::|:|     ||:|.|
  Fly    71 ITLHA-AYLKIDE---NRTSVVSGQEKFGVNRIEVNEVH----NFYILHLGRELVKDQIYK---- 123

  Fly   152 LLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIAR 216
             |:::|:..:::::.|.::|.||:...........|...|..||:.|||||||..|..||:::..
  Fly   124 -LEMHFKAGLNDSQSGYYKSNYTDIVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGY 187

  Fly   217 PKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAIN 281
            .|.|:.|...|:....:|..|.:|......|....||:...|.:..|    |:...:.|......
  Fly   188 HKKYMGLSGMPVLRCQDHDSLTNYVWCDHDTLLRTSTYLVAFAVHDL----ENAATEESKTSNRV 248

  Fly   282 IWSNNLSSTNLLDIQNKLNVAHTTI---QHFFNIPLPLTKLDVIAIPSLATLPFISAS--GILIA 341
            |:.|.:....|......:.:|...:   ::.|.|..||.|:|.:.:|   |..|.:..  |::..
  Fly   249 IFRNWMQPKLLGQEMISMEIAPKLLSFYENLFQINFPLAKVDQLTVP---THRFTAMENWGLVTY 310

  Fly   342 RESEI---------LKKD--VFEISRELIYQWIGIWITPEWWTDANVNK---------ALIS--- 383
            .|..:         .:||  .|.::.|..:||.|..:|..||.|..:.:         ||.|
  Fly   311 NEERLPQNQGDYPQKQKDSTAFTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQP 375

  Fly   384 -------FIASEIVFEINGGIEFNGKYPMTILYSLYYELSKRYPN-SHITGIKHEFASIKVQLII 440
                   ||:.::....:.  :.|...|         .:||...| :.:.|...|:...|..|.|
  Fly   376 EWRRGERFISRDLANFFSK--DSNATVP---------AISKDVKNPAEVLGQFTEYVYEKGSLTI 429

  Fly   441 RMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSR 505
            |||...||:..|..||:||:..:.|.....:|.||::...|..:..:.||.::....:||.....
  Fly   430 RMLHKLVGEEAFFHGIRSFLERFSFGNVAQADLWNSLQMAALKNQVISSDFNLSRAMDSWTLQGG 494

  Fly   506 LPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTR 570
            .||||:||:|.:....:.|..:.:|  |.: ::.:..||:|:...||:...|..|....|:....
  Fly   495 YPLVTLIRNYKTGEVTLNQSRFFQE--HGI-EKASSCWWVPLRFVRQNLPDFNQTTPQFWLECPL 556

  Fly   571 QMLISNLP---SKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAW 632
            ...:..||   |.:.::|:|.:....|.||||::||.::.:.||.:.....|....:|:||.|..
  Fly   557 NTKVLKLPDHLSTDEWVILNPQVATIFRVNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLM 621

  Fly   633 NLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLY- 696
            .||......:..|.::..:||.|::.:.|......|:::|..|..:..| ||:.|:.:||.|||
  Fly   622 ALAAVRLHKYDKAFDLLEYLKKEQDFLPWQRAIGILNRLGALLNVAEAN-KFKNYMQKLLLPLYN 685

  Fly   697 ---EYLGTAHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEY-- 756
               :..|.......|..........|..|:.....|..:|:    |...:.....:..:|:::
  Fly   686 RFPKLSGIREAKPAIKDIPFAHFAYSQACRYHVADCTDQAK----ILAITHRTEGQLELPSDFQK 746

  Fly   757 --ICSIFKWGSMKEWM--FGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNI 817
              .||:...|...|::  |||     |..|...|.| .:|....||..........|...:..:.
  Fly   747 VAYCSLLDEGGDAEFLEVFGL-----FQNSTNGSQR-RILASALGCVRNFGNFEQFLNYTLESDE 805

  Fly   818 SIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYD 882
            .:..|. .||.:.:..:|....:...:::.::...:..|| ....:...|:|.|..:.||:| .|
  Fly   806 KLLGDC-YMLAVKSALNREPLVSPTANYIISHAKKLGEKF-KKKELTGLLLSLAQNLRSTEE-ID 867

  Fly   883 LVK------KFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYL 931
            .:|      |.::|.          ::|:|...|...:|.|.......|.|:.:|
  Fly   868 RLKAQLEDLKEFEEP----------LKKALYQGKMNQKWQKDCSSDFIEAIEKHL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	122/485 (25%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	75/337 (22%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	105/426 (25%)
		M1_APN_2	37..496	CDD:189008	122/489 (25%)
		ERAP1_C	573..890	CDD:288671	76/340 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920