DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and CG31343

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	1027	Identity:	219/1027 - (21%)
Similarity:	393/1027 - (38%)	Gaps:	240/1027 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ICSSMASGTRTLFILTI---LLTAPGLEAF----VNDFSSLHVISEVRLPKEVLPLSY--EVLIE 67
            :||..|   |.:..|::   .|...|...|    |:|.|:    ...|||....|.||  |:...
  Fly    17 VCSLQA---RLILPLSLDDGQLETKGAALFATSRVDDNSA----GNYRLPNTTEPESYNVELWTN 74

  Fly    68 PHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLP 132
            .|..:..|.|::.:.:|.:.::..:..|...|     |....|             ||.|.|..|
  Fly    75 VHNGDTEFNGTVNIDIRVLNETSNITLHYRQT-----SNFEAT-------------IISRDVATP 121

  Fly   133 RK-PVFV--------LYLK-----DKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEI 183
            .. |:.|        |.|.     :.....:...:.|.:.|.......|.:.|.||:  :|||:.
  Fly   122 TAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTD--DDGEQH 184

  Fly   184 YLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDFFHT 247
            :|| |..:..|||..|||:|||..:..|.::|.....|..:.|.|::....     |..:..|.|
  Fly   185 FLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAAT-----SSGVTAFQT 244

  Fly   248 TAPMSTHAFGFVI------------LKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLN 300
            |..|||:...|::            ::..:::..   ...|.....:||..|..::|..
  Fly   245 TPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRK---GKQDQQEWALWSGLLVESSLAS------ 300

  Fly   301 VAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS-----GILIARESEI----------LKKD 350
                    :|.:|..|.|||...||.      .||.     |:...||..:          ||.:
  Fly   301 --------YFGVPFALPKLDQAGIPD------FSAGAMENWGLATYREQYMWWNKQNSTINLKTN 351

  Fly   351 VFE-ISRELIYQWIGIWITPEWWTDANVNK---ALISFIASEI---------VFEINGGIEFN-- 400
            :.. |..|..:.|.|..::.:|||...:.:   .|.|:.:::|         :|.:|   ::|
  Fly   352 IANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVN---DYNSA 413

  Fly   401 -------GKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLGIQS 458
                   ...|||.......|:|.||         :.|:..|...::.|.........||.|:..
  Fly   414 LLNDALASAVPMTHYVQTPSEISNRY---------NTFSYAKPASVLYMFKNAWTDKVFRTGLNK 469

  Fly   459 FICDYKFKTYKSSDFWNAITTQAKADNSLDSDL--SILSIAESWLEHSRLPLVTIIRDYDSETAI 521
            ::..   ..|.|.|.|:...:..::.:.|...|  |:..|..||...:..||:|:.|:|::.|..
  Fly   470 YLTK---NQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTIT 531

  Fly   522 VQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNL-PSKNMFII 585
            :.||.|:..:    .|.::..|::|:.....:...:.:|.:..::....:.:||:: .|.:.:||
  Fly   532 ITQKRYVANK----TDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWII 592

  Fly   586 VNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNVTL 650
            ||.:..|.:...||..|:.:::..|:::..|  .....||:||:|.:.......|:.|..|.:..
  Fly   593 VNIQNSGYYRTLYDTQNYGLITAALKSQPWR--FHPRNRAQLLYDTYIFVSTDRLSHSILLELLG 655

  Fly   651 FLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLGT-----AHFNEDINI 710
            :|..|:.:..||...|.|....:.|........|:.::..|:.|:::.:|.     .|:..:.
  Fly   656 YLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNY-- 718

  Fly   711 TELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMKEWMFGLDR 775
              ||.:..|..|:.|...|:.::....:.::.:. ...|..:..:..|:            ||..
  Fly   719 --LRIVLVSLACQVGSDDCYNQSANKLSEYLYNG-TAIEATLKTQAYCA------------GLRS 768

  Fly   776 LCEFPKSRIQS---------DRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIIST 831
            ......||:||         ||:..:..| ||.....::...|.|::..|.|: |.:::..::::
  Fly   769 TTNEIYSRVQSDLLSSSDSTDRSLFISSL-GCSGSTSQLLDFLRLSLDTNNSL-SYSERTSLLNS 831

  Fly   832 VTSRS-IGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHYGHF 895
            ..||| ||.|..|:||.:||                                       |.|.:.
  Fly   832 AYSRSEIGLTASLEFLESNW---------------------------------------EAYANL 857

  Fly   896 GRAQHIIEKSLRNIKEGIQWSKQN------IPVIEEWIDHYLSDAPKLAYVN 941
            ..:...::.:||.|...:...||.      :.|:|       :|.|  :|:|
  Fly   858 SDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVE-------ADGP--SYIN 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	110/510 (22%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	67/336 (20%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	99/448 (22%)
		M1_APN_2	65..517	CDD:189008	110/514 (21%)
		ERAP1_C	591..886	CDD:288671	72/354 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920