DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG40470 and ANPEP

DIOPT Version :9

Sequence 1:NP_001036635.1 Gene:CG40470 / 3355093 FlyBaseID:FBgn0058470 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001141.2 Gene:ANPEP / 290 HGNCID:500 Length:967 Species:Homo sapiens


Alignment Length:1033 Identity:250/1033 - (24%)
Similarity:444/1033 - (42%) Gaps:194/1033 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 MASG---TRTLFILTILL------------------------------TAPGLEAFVNDFSSL-- 45
            ||.|   :::|.||.|||                              |.|...|..|..|:.  
Human     1 MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTL 65

  Fly    46 ---HVISEVRLPKEVLPLSYEVLIEPHMDNQN-----FEGS--IRMHLRWIGDSKKVYFHAHDTL 100
               ...:..|||..:.|.||.|.:.|::...:     |:||  :|...:          .|.|.:
Human    66 DQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCK----------EATDVI 120

  Fly   101 LIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKP------------VFVLYLKDKIKKGSECLL 153
            :|...::|. ||:.|      :.::||||...:.|            ..|::||..:.|.|:..:
Human   121 IIHSKKLNY-TLSQG------HRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEM 178

  Fly   154 DIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPK 218
            |..|:|.:::...|.:||.|. .|| ..::...|.::..:||:.|||||||.:|..||:::..||
Human   179 DSEFEGELADDLAGFYRSEYM-EGN-VRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPK 241

  Fly   219 GYITLFN-------TPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSD 276
            ....|.|       |||      |:..::::..||||..|||:...|::.:.    ::...::|:
Human   242 DLTALSNMLPKGPSTPL------PEDPNWNVTEFHTTPKMSTYLLAFIVSEF----DYVEKQASN 296

  Fly   277 IPAINIWSNNLSSTNLLDIQNKLNVAHTTIQHF---FNIPLPLTKLDVIAIPSLATLPFISAS-- 336
            ...|.||:.. |:.........|||....:..|   ::.|.||.|.|.|.:|.     |.:.:  
Human   297 GVLIRIWARP-SAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPD-----FNAGAME 355

  Fly   337 --GILIARESEIL-----------KKDVFEISRELIYQWIGIWITPEWWTDANVNKALISFIA-- 386
              |::..||:.:|           ::.|..|:.||.:||.|..:|.|||.|..:|:...|::.  
Human   356 NWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL 420

  Fly   387 ----SEIVFEINGGIEFNGKYPMTILYSLYYELSKRYPNSHI---TGIKHEFASI---KVQLIIR 441
                :|..:.:...:..|..|.:..:.:|........|.|.|   ..|...|.:|   |...::|
Human   421 GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLR 485

  Fly   442 MLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRL 506
            |||..:.:..|:.|:.|::..:.::.....:.|:.: .:|..:.|:....::..|...|......
Human   486 MLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHL-QEAVNNRSIQLPTTVRDIMNRWTLQMGF 549

  Fly   507 PLVTIIRDYDSETAIVQQKVYLRERLHDV--PDQDNMLWWIPI-----ALKRQDSLSFVNTGSFK 564
            |::|:    |:.|..:.|:.:|.:...:|  |.:.|.:|.:||     ..::||          .
Human   550 PVITV----DTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQD----------Y 600

  Fly   565 WMNKTRQM--LISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKL 627
            |:...|..  |.|.  |.|.::::|....|.:.||||:.||..:...|:.:  ..:|||..||::
Human   601 WLIDVRAQNDLFST--SGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRD--HSAIPVINRAQI 661

  Fly   628 LHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELL 692
            ::||:|||.|.::..:.|||.||||..||.::.|....:.|.......::|.:....:.|:.:.:
Human   662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQV 726

  Fly   693 APLYEYLGTAHFNEDIN------------ITELRKLTTSFLCKAGYFPCFKEARRAFNIWI---- 741
            .||:     .||..:.|            .:|:..::|:  |..|...|.:.....|..|:    
Human   727 TPLF-----IHFRNNTNNWREIPENLMDQYSEVNAISTA--CSNGVPECEEMVSGLFKQWMENPN 784

  Fly   742 -NSSFPNFETPVPNEYICSIFKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKI 805
             |...||..:.|    .|:....|..:||.|..:   :|..:.:.::...|...|| |..:   :
Human   785 NNPIHPNLRSTV----YCNAIAQGGEEEWDFAWE---QFRNATLVNEADKLRAALA-CSKE---L 838

  Fly   806 FILLE-LAILKNISIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLIS 869
            :||.. |:...|..:....|....|.::|:..||...:.||:.:||..:.:.:...:..::.||.
Human   839 WILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQ 903

  Fly   870 SATGMFSTQEGYDLVKKF-YDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEW 926
            :.|..|||:.....:::| .|.....||.....:|::|...|..|:|.|:|..|:.:|
Human   904 AVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG40470NP_001036635.1 GluZincin 60..503 CDD:301352 121/498 (24%)
ERAP1_C 584..906 CDD:288671 83/340 (24%)
ANPEPNP_001141.2 Cytosolic Ser/Thr-rich junction 33..68 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..62 4/21 (19%)
Metalloprotease 69..967 236/965 (24%)
M1_APN-Q_like 84..545 CDD:341064 121/496 (24%)
Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485 288..295 0/6 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:22932899 352..356 0/3 (0%)
ERAP1_C 619..946 CDD:403137 84/346 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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