DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and ape2

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	932	Identity:	213/932 - (22%)
Similarity:	389/932 - (41%)	Gaps:	137/932 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINL----TTLN 113
            |||.|.|:.|::.:.|.::...:.|.:.:.|..:.||..:..|.          |||    ..|.
pombe    20 LPKNVKPIHYDLSLYPDLETFTYGGKVVVTLDVLEDSNSITLHG----------INLRILTAALE 74

  Fly   114 MGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGN 178
            .|..|:..:.:.....|:      ||.....:...|..:|.:.|...||...||.:||.|.:|
pombe    75 WGSQTVWASEVSYGDERI------VLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDS-- 131

  Fly   179 DGEEIYLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL 242
            ||...||| |.::|.:|||.|||:|||.:|..|.:.|...:.|..|.|.   |.:..........
pombe   132 DGNTKYLATTQMEPTSARRAFPCWDEPALKATFTIDITAKENYTILSNM---NAVEETVKDGLKT 193

  Fly   243 DFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKL--NVAHTT 305
            ..|..|..|||:...:::.:|. :.|: .......|.:.:   .:.:|.....|.|.  .:...|
pombe   194 ARFAETCRMSTYLLAWIVAELE-YVEY-FTPGKHCPRLPV---RVYTTPGFSEQGKFAAELGAKT 253

  Fly   306 IQHF---FNIPLPLTKLDVIAIPSLAT-------LPFISASGILIARES--EILKKDVFEISREL 358
            :..|   |..|.||.|.|::|||....       |.....:.||::.:|  .::::....:..||
pombe   254 LDFFSGVFGEPYPLPKCDMVAIPDFEAGAMENWGLVTYRLAAILVSEDSAATVIERVAEVVQHEL 318

  Fly   359 IYQWIGIWITPEWWTDANVNKALISFIA---------------SEIVFEINGGIEFN---GKYPM 405
            .:||.|..:|.::|....:|:...::::               |.:...:...:..:   ..:|:
pombe   319 AHQWFGNLVTMQFWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPI 383

  Fly   406 TILYSLYYELSKRYPNSHITGIKHEFASI---KVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKT 467
            .:            |..|...|...|.:|   |...:|||:|..||:.||..|||.:|..:::..
pombe   384 EV------------PIMHDYEINQIFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGN 436

  Fly   468 YKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERL 532
            ..:.|.|.|::.::..|        |.|...:|.:.:..|::::....|.|..|.|.:..   ..
pombe   437 TVTEDLWAALSAESGQD--------ISSTMHNWTKKTGYPVLSVSETNDGELLIEQHRFL---ST 490

  Fly   533 HDV-PDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISN--LPSKNMFIIVNEEEIGPF 594
            .|| |::|.:::|.|:.||.......|........::::::.:..  |.|..:    |.|:.|.:
pombe   491 GDVKPEEDTVIYWAPLKLKTMKDGKAVVDEKAVLSDRSKKIKVDKEALESYKL----NSEQSGIY 551

  Fly   595 PVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHI 659
            .|||..::...||:.  ..||.:.:.|..||.|:.|..:|:.||....|:.|::....|.|.|.:
pombe   552 RVNYSADHLKKLSQI--AVEKPDYLSVEDRAGLIADVASLSRAGYGKVSSTLDLIKTWKDEPNFV 614

  Fly   660 VWSPVFTFLDQVGK--RLEKSSINKKFELYIIELLAPLYEYLGTAHFNEDINITELRKLTTSFLC 722
            |::.:...|:.:..  |.|.|.|....:..::|:.|.....||......|.:|  :|:..::...
pombe   615 VFAEMLARLNGIKSTLRFESSDIIAAMKKLVLEVSATKAHSLGWEFKANDDHI--IRQFKSTVYN 677

  Fly   723 KAGYF---PCFKEARRAFNIWINSSFPNFETPVPNEYICSIF----KWGSMKEWMFGLDRLCE-F 779
            .||.|   ...|:|...|:.:.:.:    ::.:.:....::|    ::|..|.|    |:|.| :
pombe   678 YAGLFGDDKVVKDALSKFDAYASGN----KSAINDNLRSAVFNIAIRYGGAKSW----DQLLEIY 734

  Fly   780 PKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRSIGYTTLLD 844
            .|:.....|...|:...   ...|:.:|...|.:..: .|..:.|..||:.|:::...|...:..
pombe   735 TKTNDPYVRNSCLRAFG---VTEDEKYIQKTLDLTLD-PIVKEQDIYLILVTLSTHKNGVLAMWK 795

  Fly   845 FLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFY-DEHYGHFGRA---------- 898
            |.::|||.:..:......:...::...|..|:.....|.:|:|: |:....:.||
pombe   796 FATSNWDKLLSRLPVAGTMRGYVVRFVTSGFTHASAIDKIKEFFADKDTKLYERALQQSLDTISA 860

  Fly   899 -QHIIEKSLRNIKEGIQWSKQN 919
             ...|:|||.:|   .:|.|:|
pombe   861 NSSFIDKSLDDI---TRWLKEN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	111/482 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	75/343 (22%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	206/915 (23%)
		M1_APN_2	27..468	CDD:189008	111/486 (23%)
		ERAP1_C	541..857	CDD:288671	73/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910